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Showing 1–11 of 11 results
Advanced filters: Author: Alexander J. Northrop Clear advanced filters

  • As more spaceflight missions plan to take humans back to the moon — and beyond — a key goal is to understand how spaceflight affects the immune system. In this Review, researchers from academia and international space agencies discuss the emergence of the field of ‘astroimmunology’. They outline the main immunological challenges we must overcome to facilitate safe space exploration by humans.

    • Daniel A. Winer
    • Huixun Du
    • Brian E. Crucian
    Reviews
    Nature Reviews Immunology
    P: 1-24

  • Hyperbolic phonon polaritons occurring in anisotropic materials exhibit strong light confinement and propagation directionality. Matson et al. report real-space imaging and control of recently discovered hyperbolic shear phonon-polaritons in beta-Ga2O3, arising from symmetry breaking in the dielectric response.

    • Joseph Matson
    • Sören Wasserroth
    • Joshua D. Caldwell
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-8

  • The current ‘second space age’ has enabled multiple studies on the effects of spaceflight on human physiology and health, which are contributing to the development of measures that will be needed to maintain astronaut health in future space missions.

    • Christopher E. Mason
    • James Green
    • Afshin Beheshti
    Reviews
    Nature
    Volume: 632, P: 995-1008

  • Genomic analysis of 551 esophageal adenocarcinomas identifies new driver mutations and biomarkers associated with poor prognosis. More than 50% of esophageal adenocarcinomas contain sensitizing events for CDK4/CDK6 inhibitors, thus providing an evidence base for targeted therapeutics.

    • Alexander M. Frankell
    • SriGanesh Jammula
    • Rebecca C. Fitzgerald
    Research
    Nature Genetics
    Volume: 51, P: 506-516

  • Nonlinear optical interactions can be substantially enhanced by the wavelength-scale confinement in integrated photonics, providing transformative capabilities for controlling, enhancing and manipulating material nonlinearities in miniaturized platforms. In this Review, we outline the design principles that harness the potential of nonlinear optical materials on integrated platforms and their utility in applications including broadband frequency conversion, frequency-comb generation, quantum light sources and nonlinear optical quantum logic gates.

    • Avik Dutt
    • Aseema Mohanty
    • Michal Lipson
    Reviews
    Nature Reviews Materials
    Volume: 9, P: 321-346

  • The work of Michael Angelo and colleagues uses multiplexed ion beam imaging (MIBI) to localize and visualize protein expression in a manner analogous to immunohistochemistry (IHC) while circumventing some of the limitations of conventional IHC with clinical samples. MIBI uses secondary ion mass spectrometry to image antibodies tagged with isotopically pure elemental metal reporters, expanding the number of targets that can be analyzed simultaneously to about 100. The approach, used here to image breast tumor tissue sections, offers over a five-log dynamic range and compatibility with standard formalin-fixed, paraffin-embedded tissue sections.

    • Michael Angelo
    • Sean C Bendall
    • Garry P Nolan
    Research
    Nature Medicine
    Volume: 20, P: 436-442