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Showing 1–3 of 3 results
Advanced filters: Author: Alon Monsonego Clear advanced filters

  • Elyahu and colleagues describe the reciprocal interplay between senescent cells (SCs) and a helper T cell population that accumulates during aging. They show that selective depletion of this T cell population increases SC accumulation, accelerates frailty and limits lifespan in mice.

    • Yehezqel Elyahu
    • Ilana Feygin
    • Alon Monsonego
    Research
    Nature Aging
    P: 1-13

  • This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet and infections, and host-intrinsic factors, such as the activity of microglial cells and other immune, vascular and neuronal cell populations, on disease development. They also highlight emerging drugs that target this inflammatory component for therapy of Alzheimer disease.

    • Michael T. Heneka
    • Wiesje M. van der Flier
    • Sean-Patrick Riechers
    Reviews
    Nature Reviews Immunology
    Volume: 25, P: 321-352