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In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma

In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.

Nelson H. Knudsen
Giulia Escobar
Marcela V. Maus
Research24 Sept 2025
Nature

P: 1-10
Anti-TACI single and dual-targeting CAR T cells overcome BCMA antigen loss in multiple myeloma

Patients with myeloma multiple treated with BCMA CAR T cells often relapse with BCMA-negative disease or antigen escape. Here the authors describe the design of TACI-directed single and dual CAR T cells with in vitro and in vivo activity against multiple myeloma, overcoming BCMA antigen loss.

Rebecca C. Larson
Michael C. Kann
Marcela V. Maus
ResearchOpen Access18 Nov 2023
Nature Communications

Volume: 14, P: 1-15
Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques

Intratracheal boosting with a bivalent Ad26-based SARS-CoV-2 vaccine results in substantial induction of mucosal humoral and cellular immunity and near-complete protection against SARS-CoV-2 BQ.1.1 in rhesus macaques.

Katherine McMahan
Frank Wegmann
Dan H. Barouch
ResearchOpen Access14 Dec 2023
Nature

Volume: 626, P: 385-391
CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity

BiTE-secreting CAR-T cells overcome antigen escape from EGFRvIII-targeted therapy for glioblastoma.

Bryan D. Choi
Xiaoling Yu
Marcela V. Maus
Research22 Jul 2019
Nature Biotechnology

Volume: 37, P: 1049-1058
CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours

A genome-wide CRISPR knockout screen in a model of glioblastoma shows that killing by chimeric antigen receptor T cells requires interferon-γ receptor-dependent adhesion to tumour cells, but cytotoxicity of liquid tumours does not rely on this pathway.

Rebecca C. Larson
Michael C. Kann
Marcela V. Maus
Research13 Apr 2022
Nature

Volume: 604, P: 563-570
Chemical genetic control of cytokine signaling in CAR-T cells using lenalidomide-controlled membrane-bound degradable IL-7

Michael C. Kann
Emily M. Schneider
Max Jan
Research20 Dec 2023
Leukemia

Volume: 38, P: 590-600

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In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma

Anti-TACI single and dual-targeting CAR T cells overcome BCMA antigen loss in multiple myeloma

Mucosal boosting enhances vaccine protection against SARS-CoV-2 in macaques

CAR-T cells secreting BiTEs circumvent antigen escape without detectable toxicity

CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours

Chemical genetic control of cytokine signaling in CAR-T cells using lenalidomide-controlled membrane-bound degradable IL-7

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