Lauren Ostrowski, Amanda Hall et al. report a molecular characterization of Pbp1, the yeast ortholog of the neurodegenerative disease-associated human ATXN2. They find that Pbp1 knockout or polyQ expansion compromises rDNA repeat stability via a mechanism linking neurodegenerative protein aggregation and aging.
- Lauren A. Ostrowski
- Amanda C. Hall
- Karim Mekhail
