Nature Search

Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study

Estimates from the Global Burden of Disease study reveal declines in chronic respiratory disease mortality between 1990 and 2023—especially during the COVID-19 pandemic—but the burdens on people affected remain substantial.

Jiyeon Oh
Soeun Kim
Dong Keon Yon
Research06 Jan 2026
Nature Medicine

Volume: 32, P: 197-223
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Age-related loss of gene-to-gene transcriptional coordination among single cells

Levy et al. report a method to measure transcriptional coordination between cells in single-cell RNA sequencing data and demonstrate that transcriptional dysregulation between cells is a general phenomenon in ageing and is associated with genetic damage.

Orr Levy
Guy Amit
Amir Bashan
Research02 Nov 2020
Nature Metabolism

Volume: 2, P: 1305-1315
Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

With age, haematopoietic stem cells (HSCs) produce more myeloid than lymphoid cells, affecting adaptive immunity. By combining HSC single cell transcriptomics with functional studies, Grover et al. find that platelet production is also increased in old murine HSCs and show that the FOG-1 transcription factor contributes to the age-dependent platelet bias.

Amit Grover
Alejandra Sanjuan-Pla
Claus Nerlov
ResearchOpen Access24 Mar 2016
Nature Communications

Volume: 7, P: 1-12
Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

Florian Grebien
Masoud Vedadi
Giulio Superti-Furga
Amendments and Corrections17 Sept 2015
Nature Chemical Biology

Volume: 11, P: 815
Quantum supremacy using a programmable superconducting processor

Quantum supremacy is demonstrated using a programmable superconducting processor known as Sycamore, taking approximately 200 seconds to sample one instance of a quantum circuit a million times, which would take a state-of-the-art supercomputer around ten thousand years to compute.

Frank Arute
Kunal Arya
John M. Martinis
Research23 Oct 2019
Nature

Volume: 574, P: 505-510
Using buoyant mass to measure the growth of single cells

A microfluidic device containing a suspended microchannel resonator capable of measuring the mass of microscopic objects with femtogram resolution allows determination of bacteria, yeast and mammalian cell growth rates in less than one cell cycle by repeated measurement of the buoyant mass of single growing cells.

Michel Godin
Francisco Feijó Delgado
Scott R Manalis
Research11 Apr 2010
Nature Methods

Volume: 7, P: 387-390
Distinct myeloid progenitor–differentiation pathways identified through single-cell RNA sequencing

Using single-cell transcriptome profiling of pre-granulocyte-macrophage progenitor cells, Nerlov and colleagues identify an early hematopoietic lineage bifurcation that segregates mast cells, eosinophils, megakaryocytes and erythroid cells from monocytes, neutrophils and lymphocytes.

Roy Drissen
Natalija Buza-Vidas
Claus Nerlov
Research04 Apr 2016
Nature Immunology

Volume: 17, P: 666-676
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) is an anti-inflammatory drug proposed as a treatment for COVID19. Here the results are reported from a randomised trial testing DMF treatment in 713 patients hospitalised with COVID-19. DMF was not associated with any improvement in day 5 outcomes.

Peter Sandercock
Janet Darbyshire
Martin J. Landray
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

The p30 isoform of C/EBPα associated with leukemia interacts with WDR5, a component of the SET/MLL histone methyltransferase complex. A small molecule, OICR-9429, disrupted p30-WDR5 interactions, resulting in differentiation of p30-expressing leukemia cells.

Florian Grebien
Masoud Vedadi
Giulio Superti-Furga
Research13 Jul 2015
Nature Chemical Biology

Volume: 11, P: 571-578
Global coordination level in single-cell transcriptomic data

Guy Amit
Dana Vaknin Ben Porath
Amir Bashan
ResearchOpen Access09 May 2022
Scientific Reports

Volume: 12, P: 1-11
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

Heather J. Cordell
Younghun Han
Katherine A. Siminovitch
ResearchOpen Access22 Sept 2015
Nature Communications

Volume: 6, P: 1-11
Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy

The identification of a functionally distinct subset of haematopoietic stem cells (HSCs) that is primed for platelet-specific gene expression is described; the cells frequently have long-term myeloid lineage bias, can self-renew and give rise to lymphoid-biased HSCs, and may enable the design of therapies for enhancing platelet reconstitution.

Alejandra Sanjuan-Pla
Iain C. Macaulay
Sten Eirik W. Jacobsen
Research11 Aug 2013
Nature

Volume: 502, P: 232-236
Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells

Analysis of transplantation of single haematopoietic stem cells in mice defines stable lineage-restricted fates in long-term self-renewing multipotent stem cells, including a class of multipotent stem cells that exclusively replenishes the megakaryocyte/platelet lineage.

Joana Carrelha
Yiran Meng
Sten Eirik W. Jacobsen
Research03 Jan 2018
Nature

Volume: 554, P: 106-111
Gut commensals-derived succinate impels colonic inflammation in ulcerative colitis

Rajdeep Dalal
Srikanth Sadhu
Amit Awasthi
ResearchOpen Access13 Mar 2025
npj Biofilms and Microbiomes

Volume: 11, P: 1-14
Effect of synbiotics on growth performance, gut health, and immunity status in pre-ruminant buffalo calves

Amit N. Sharma
Parul Chaudhary
Goutam Mondal
ResearchOpen Access22 Jun 2023
Scientific Reports

Volume: 13, P: 1-12
Medical and surgical interventions and outcomes for infants with trisomy 18 (T18) or trisomy 13 (T13) at children’s hospitals neonatal intensive care units (NICUs)

Krishna Acharya
Steven R. Leuthner
Michel Mikhael
Research10 Jun 2021
Journal of Perinatology

Volume: 41, P: 1745-1754
The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

Rachel L O’Connell
Tim Rattay
Mohammed Mustafa
ResearchOpen Access29 Mar 2019
British Journal of Cancer

Volume: 120, P: 883-895
Antimicrobial therapy utilization in neonates with hypoxic-ischemic encephalopathy (HIE): a report from the Children’s Hospital Neonatal Database (CHND)

Rakesh Rao
Kyong-Soon Lee
An Massaro
Research14 Oct 2019
Journal of Perinatology

Volume: 40, P: 70-78

Search

Filter By:

Search

Quick links