Amr Ghaleb et al. find that, in an ErbB2 mouse model, irradiation of premalignant mammary lesions enhances tumorigenesis in tumours that are heterozygous for p53 containing a p53 R172H mutation. This is associated with loss of the wild-type p53 allele, stabilisation of mutant p53 protein and activation of mTOR signaling.
- Amr Ghaleb
- Alisha Yallowitz
- Natalia Marchenko
