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Showing 1–3 of 3 results
Advanced filters: Author: An Buckinx Clear advanced filters

  • The role of lactate in the control of microglial function remains poorly investigated. Here, the authors show that lactate promotes lysosomal acidification in microglia, and that mice lacking the lactate transporter MCT4 in these cells display defective brain development and anxiety-like behavior.

    • Katia Monsorno
    • Kyllian Ginggen
    • Rosa Chiara Paolicelli
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-18

  • Androgen receptor (AR) signalling plays an important role in several cancers beyond prostate cancer. This Review highlights the context-dependent functions of AR in non-prostatic malignancies, examining the intrinsic function of AR in cancer cells and the tumour microenvironment, and summarizes ongoing AR-targeted clinical trials.

    • G. Paolo Dotto
    • An Buckinx
    • Christian Simon
    Reviews
    Nature Reviews Cancer
    Volume: 25, P: 93-108