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Efficacy of an unmodified bivalent mRNA vaccine against SARS-CoV-2 variants in female small animal models

Here the authors show efficacy of a low-dose, unmodified, bivalent mRNA vaccine against SARS-CoV-2 variants in two female rodent models and find that combination of mRNA encoding Beta and Delta Spike sequences induces broadly neutralizing antibodies and robust T-cell responses.

Björn Corleis
Donata Hoffmann
Anca Dorhoi
ResearchOpen Access13 Feb 2023
Nature Communications

Volume: 14, P: 1-8
AhR sensing of bacterial pigments regulates antibacterial defence

The mammalian aryl hydrocarbon receptor (known to sense environmental pollutants) is shown to also have a role as a pattern recognition receptor in sensing bacterial virulence factors, resulting in an antibacterial response and activation of innate and natural defences.

Pedro Moura-Alves
Kellen Faé
Stefan H. E. Kaufmann
Research13 Aug 2014
Nature

Volume: 512, P: 387-392
Concordant and discordant gene expression patterns in mouse strains identify best-fit animal model for human tuberculosis

Teresa Domaszewska
Lisa Scheuermann
January Weiner 3rd
ResearchOpen Access21 Sept 2017
Scientific Reports

Volume: 7, P: 1-13
CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2

Emerging SARS-CoV-2 variants with mutations in the spike protein raise concerns regarding vaccine efficacy. Here, the authors show that two spike encoding mRNA vaccines in preclinical and clinical development protect human ACE2 mice from the B.1.351 variant of concern and ancestral B BavPat1.

Donata Hoffmann
Björn Corleis
Martin Beer
ResearchOpen Access30 Jun 2021
Nature Communications

Volume: 12, P: 1-7
Bat organoids reveal antiviral responses at epithelial surfaces

Kellner et al. develop respiratory and intestinal organoids from Rousettus aegyptiacus to show elevated basal expression of interferon-ε (IFNε) and IFN-stimulated genes, along with robust, self-amplifying type III IFN responses that drive antiviral defense against zoonotic RNA viruses.

Max J. Kellner
Vanessa M. Monteil
Josef M. Penninger
ResearchOpen Access21 May 2025
Nature Immunology

Volume: 26, P: 934-946
Host-directed therapies for bacterial and viral infections

Host-directed therapy (HDT) aims to interfere with host cell factors that are required by a pathogen for replication or persistence. In this Review, Kaufmannet al. describe recent progress in the development of HDTs for the treatment of viral and bacterial infections and the challenges in bringing these approaches to the clinic.

Stefan H. E. Kaufmann
Anca Dorhoi
Ralf Bartenschlager
Reviews22 Sept 2017
Nature Reviews Drug Discovery

Volume: 17, P: 35-56
Monocyte progenitors give rise to multinucleated giant cells

Multinucleated giant cells characterize granuloma formation in mycobacterial infections. Here the authors identify monocyte precursors with distinct immunological and metabolic properties as a source of the granuloma multinucleated giant cell compartment.

Anne Kathrin Lösslein
Florens Lohrmann
Philipp Henneke
ResearchOpen Access01 Apr 2021
Nature Communications

Volume: 12, P: 1-22
The Mycobacterium tuberculosis regulatory network and hypoxia

Mycobacterium tuberculosis has the ability to survive within the host for months to decades in an asymptomatic state, and adaptations to hypoxia are thought to have an important role in pathogenesis; here a systems-wide reconstruction of the regulatory network provides a framework for understanding mycobacterial persistence in the host.

James E. Galagan
Kyle Minch
Gary K. Schoolnik
Research03 Jul 2013
Nature

Volume: 499, P: 178-183
Author Correction: Phosphatidylinositolmannoside vaccination induces lipid-specific Th1-responses and partially protects guinea pigs from Mycobacterium tuberculosis challenge

Emmelie Eckhardt
Jan Schinköthe
Max Bastian
Amendments and CorrectionsOpen Access18 Dec 2023
Scientific Reports

Volume: 13, P: 1
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

DNA damage induces translocation of cyclic GMP–AMP synthase to the nucleus, where it suppresses homologous recombination by interfering with the formation of the PARP1–Timeless complex.

Haipeng Liu
Haiping Zhang
Baoxue Ge
Research24 Oct 2018
Nature

Volume: 563, P: 131-136
Phosphatidylinositolmannoside vaccination induces lipid-specific Th1-responses and partially protects guinea pigs from Mycobacterium tuberculosis challenge

Emmelie Eckhardt
Jan Schinköthe
Max Bastian
ResearchOpen Access30 Oct 2023
Scientific Reports

Volume: 13, P: 1-15
Selection and stability validation of reference gene candidates for transcriptional analysis in Rousettus aegyptiacus

Virginia Friedrichs
Anne Balkema-Buschmann
Gang Pei
ResearchOpen Access04 Nov 2021
Scientific Reports

Volume: 11, P: 1-10

Search

Efficacy of an unmodified bivalent mRNA vaccine against SARS-CoV-2 variants in female small animal models

AhR sensing of bacterial pigments regulates antibacterial defence

Concordant and discordant gene expression patterns in mouse strains identify best-fit animal model for human tuberculosis

CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2

Bat organoids reveal antiviral responses at epithelial surfaces

Host-directed therapies for bacterial and viral infections

Monocyte progenitors give rise to multinucleated giant cells

The Mycobacterium tuberculosis regulatory network and hypoxia

Author Correction: Phosphatidylinositolmannoside vaccination induces lipid-specific Th1-responses and partially protects guinea pigs from Mycobacterium tuberculosis challenge

Nuclear cGAS suppresses DNA repair and promotes tumorigenesis

Phosphatidylinositolmannoside vaccination induces lipid-specific Th1-responses and partially protects guinea pigs from Mycobacterium tuberculosis challenge

Selection and stability validation of reference gene candidates for transcriptional analysis in Rousettus aegyptiacus

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