Thereelermutant mouse has been used as a model of abnormal brain development for over 50 years. These mice lack a protein called Reelin, and they show a series of developmental abnormalities. Mice lacking two other proteins — the very low density lipoprotein receptor, and the apolipoprotein E receptor-2 — have now been found to show the same abnormalities, indicating that these molecules are involved in the Reelin signalling pathway.
- Isabelle Bar
- André M. Goffinet
