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In vivo armed macrophages curb liver metastasis through tumor-reactive T-cell rejuvenation

Liver metastases are a clinical problem, with low responses to immunotherapy. Here, authors coordinate expression of tumor antigens IFNα and IL-12 in liver and tumor associated macrophages to rejuvenate tumor reactive T cells and eliminate liver metastases.

Marco Notaro
Maristella Borghetti
Mario Leonardo Squadrito
ResearchOpen Access11 Apr 2025
Nature Communications

Volume: 16, P: 1-24
Mechanisms of hematopoietic clonal dominance in VEXAS syndrome

Analyses of single-cell transcriptomic data from patients with VEXAS syndrome combined with xenotransplantation experiments in a mouse model of the disease provide insights on the mechanisms of clonal dominance of mutated cells leading to bone marrow failure

Raffaella Molteni
Martina Fiumara
Samuele Ferrari
ResearchOpen Access07 Apr 2025
Nature Medicine

Volume: 31, P: 1911-1924
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

Cholesterol homeostasis can modulate immunity via multiple pathways. Here the authors show that apolipoprotein E, an important regulator of cholesterol, produced by myeloid cells can regulate T cell activation by controlling the antigen presentation activity of dendritic cells in both humans and mice.

Fabrizia Bonacina
David Coe
Giuseppe D. Norata
ResearchOpen Access06 Aug 2018
Nature Communications

Volume: 9, P: 1-15
Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates

“Lentiviral gene therapy to the liver establishes stable long-term normal to supra-normal coagulation factor VIII activity in mouse models of hemophilia A and in non-human primates, representing a potential new treatment option for people with hemophilia A.”.

Michela Milani
Cesare Canepari
Alessio Cantore
ResearchOpen Access04 May 2022
Nature Communications

Volume: 13, P: 1-14
Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens

An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα reprograms the leukemia-induced immunosuppressive TME into immunostimulatory and enhances T-cell responses.

Giulia Escobar
Luigi Barbarossa
Luigi Naldini
ResearchOpen Access24 Jul 2018
Nature Communications

Volume: 9, P: 1-16
From sociology of quantification to ethics of quantification

Andrea Saltelli
Monica Di Fiore
ResearchOpen Access19 Aug 2020
Humanities and Social Sciences Communications

Volume: 7, P: 1-8
Unscrambling light—automatically undoing strong mixing between modes

Andrea Annoni
Emanuele Guglielmi
Francesco Morichetti
ResearchOpen Access30 Jun 2017
Light: Science & Applications

Volume: 6, P: e17110

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In vivo armed macrophages curb liver metastasis through tumor-reactive T-cell rejuvenation

Mechanisms of hematopoietic clonal dominance in VEXAS syndrome

Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

Liver-directed lentiviral gene therapy corrects hemophilia A mice and achieves normal-range factor VIII activity in non-human primates

Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens

From sociology of quantification to ethics of quantification

Unscrambling light—automatically undoing strong mixing between modes

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