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Psychoneuroimmunology of Early-Life Stress: The Hidden Wounds of Childhood Trauma?

Andrea Danese
Stephanie J Lewis
Reviews15 Sept 2016
Neuropsychopharmacology

Volume: 42, P: 99-114
Genetic and environment influences on childhood victimization: a systematic review and meta-analysis

Tarik Dahoun
Alicia Peel
Andrea Danese
ReviewsOpen Access11 Dec 2024
Molecular Psychiatry

Volume: 30, P: 2228-2238
Revisiting the use of adverse childhood experience screening in healthcare settings

Screening for adverse childhood experiences can improve mental health outcomes through personalized treatments in at-risk individuals or preventative strategies at the population level. In this Review, Danese et al. synthesize the challenges and opportunities of these screening measures and related analytical methods.

Andrea Danese
Kirsten Asmussen
Angela Sweeney
Reviews25 Sept 2024
Nature Reviews Psychology

Volume: 3, P: 729-740
Evidence for Immune Activation and Resistance to Glucocorticoids Following Childhood Maltreatment in Adolescents Without Psychopathology

Carine Hartmann do Prado
Rodrigo Grassi-Oliveira
Moisés Evandro Bauer
Research30 Jun 2017
Neuropsychopharmacology

Volume: 42, P: 2272-2282
Objective and subjective experiences of child maltreatment and their relationships with psychopathology

In a cohort of 1,196 children followed to age 29 years, the authors found that risk of psychopathology was more strongly associated with subjective recall of childhood maltreatment histories than with objective, court-documented evidence of maltreatment.

Andrea Danese
Cathy Spatz Widom
Research18 May 2020
Nature Human Behaviour

Volume: 4, P: 811-818
Genetic associations with parental investment from conception to wealth inheritance in six cohorts

A study in 36,516 parents across six international cohorts reveals that parental genetic effects are associated with the investments that parents make in their offspring, from adopting more healthy behaviours during pregnancy to leaving wealth to adult children.

Jasmin Wertz
Terrie E. Moffitt
Avshalom Caspi
ResearchOpen Access29 Jun 2023
Nature Human Behaviour

Volume: 7, P: 1388-1401
Regulation of leukocyte recruitment by the long pentraxin PTX3

Leukocytes enter inflamed tissues by initiating selectin-dependent rolling on reactive endothelia. Mantovani and colleagues show that the long pentraxin PTX3 competes for P-selectin and acts to limit neutrophil extravasation.

Livija Deban
Remo Castro Russo
Alberto Mantovani
Research07 Mar 2010
Nature Immunology

Volume: 11, P: 328-334
BAP1 regulates IP3R3-mediated Ca²⁺ flux to mitochondria suppressing cell transformation

BRCA1-associated protein 1 (BAP1) regulates calcium flux in the endoplasmic reticulum to facilitate the execution of apoptosis, unveiling a new facet of the role of BAP1 as an environmental tumour suppressor.

Angela Bononi
Carlotta Giorgi
Michele Carbone
Research14 Jun 2017
Nature

Volume: 546, P: 549-553
Testing the causal relationships of physical activity and sedentary behaviour with mental health and substance use disorders: a Mendelian randomisation study

Eleonora Iob
Jean-Baptiste Pingault
Andrea Danese
ResearchOpen Access21 Jul 2023
Molecular Psychiatry

Volume: 28, P: 3429-3443
A genetically informed Registered Report on adverse childhood experiences and mental health

In 11,407 children, Baldwin et al. report gene–environment correlations between polygenic scores for psychiatric disorders and adverse childhood experiences, as well as partial genetic confounding of associations between adverse childhood experiences and mental health.

Jessie R. Baldwin
Hannah M. Sallis
Jean-Baptiste Pingault
Research08 Dec 2022
Nature Human Behaviour

Volume: 7, P: 269-290
IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes

Most of the more than 200 known genetic risk loci for inflammatory bowel disease (IBD) reside in regulatory regions. Here, the authors provide eQTL datasets for six circulating immune cell types and ileal, colonic and rectal biopsies to map regulatory modules and identify potential causative genes for IBD.

Yukihide Momozawa
Julia Dmitrieva
Michel Georges
ResearchOpen Access21 Jun 2018
Nature Communications

Volume: 9, P: 1-18
Leptin deficiency in maltreated children

A Danese
R Dove
L Arseneault
ResearchOpen Access23 Sept 2014
Translational Psychiatry

Volume: 4, P: e446
Childhood maltreatment and obesity: systematic review and meta-analysis

A Danese
M Tan
Research21 May 2013
Molecular Psychiatry

Volume: 19, P: 544-554
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Research23 Jan 2020
Molecular Psychiatry

Volume: 25, P: 1430-1446
High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

John Rioux, Andre Franke, Tom Karlsen and colleagues perform a fine-mapping study of the HLA region in Crohn's disease and ulcerative colitis. They identify a primary role for HLA-DRB1*01:03 in both diseases and find evidence of heterozygous advantage in protection against ulcerative colitis.

Philippe Goyette
Gabrielle Boucher
John D Rioux
Research05 Jan 2015
Nature Genetics

Volume: 47, P: 172-179
Assessment of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and platelet count as predictors of long-term outcome after R0 resection for colorectal cancer

Corrado Pedrazzani
Guido Mantovani
Alfredo Guglielmi
ResearchOpen Access04 May 2017
Scientific Reports

Volume: 7, P: 1-10
Clinical prediction models in psychiatry: a systematic review of two decades of progress and challenges

Alan J. Meehan
Stephanie J. Lewis
Andrea Danese
ReviewsOpen Access01 Apr 2022
Molecular Psychiatry

Volume: 27, P: 2700-2708
Biological embedding of stress through inflammation processes in childhood

A Danese
A Caspi
L Arseneault
Correspondence16 Feb 2010
Molecular Psychiatry

Volume: 16, P: 244-246
Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Amendments and Corrections18 May 2020
Molecular Psychiatry

Volume: 26, P: 5465
Increased Pituitary Volume in Antipsychotic-Free and Antipsychotic-Treated Patients of the Æsop First-Onset Psychosis Study

Carmine M Pariante
Paola Dazzan
Robin M Murray
Research01 Jun 2005
Neuropsychopharmacology

Volume: 30, P: 1923-1931

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