Search

A RAB5A-mediated, epidermal growth factor-dependent activation of endosomal ERK1/2 is identified as a key molecular route for a solid-to-liquid-like phase transition, sufficient to overcome kinetic and proliferation arrest in normal mammary epithelial assemblies and to promote collective invasion in breast carcinoma.

LRRK2 is one of the most commonly mutated genes in familial Parkinson’s disease. Here, the authors report a cryo-EM structure of the catalytic half of LRRK2 bound to microtubules, revealing determinants of binding that are independent of LRRK2 kinase activity.

How land-tenure regimes affect deforestation remains ambiguous. This study shows how deforestation in Brazil is land-tenure dependent, and how strategies to effectively reduce deforestation can range from strengthening poorly defined rights to strengthening conservation-focused regimes.

Battiston et al. discuss the emerging paradigm of higher-order network science and its applications to social systems and human dynamics.

Water vibrational motion, which occurs on the few-femtosecond timescale and underpins energy transfer within the hydrogen bonding network, has remained challenging to observe in real time due to constraints in time resolution. Here, the authors investigate the ground state vibrational dynamics of liquid water using a sub-5 fs near-infrared pump pulse and few-fs ultraviolet probe pulses, observing rapid dephasing of the OH stretch mode that precedes its relaxation via coupling to the bend modes.

Deposition of single molecule magnets onto surfaces is a key step for integration in devices exploiting their magnetic bistability and quantum properties. Here, Sessoli and colleagues exploit synchrotron Mössbauer spectroscopy to assess the effects of molecule-surface interactions on the magnetic properties of Fe(III) SMMs.

The identification of kinases that control epigenetic mechanisms in squamous cell carcinomas (SCCs) can be of therapeutic relevance. Here the authors show that loss of nuclear kinase ULK3 impairs the recruitment of two histone arginine methyltransferases, PRMT1 and PRMT5 to the promoter regions of genes of functions, hence, suppressing the tumorigenic potential of SCC cells.

Anodic pulsing during electrocatalytic CO₂ reduction has been shown to enhance activity and selectivity towards hydrocarbons and alcohols on copper yet the nature of the active sites remains unclear. Here, correlated spectro-microscopy in a quasi in situ experimental set-up provides information on the formation of specific facets and oxidation states under reactive conditions.

Here the authors show that extremes in the summer jet stream position over Europe create a beech forest productivity dipole between northwestern and southeastern Europe and can result in regional anomalies in forest carbon uptake and growth.

Nielsen et al. show that granulin is secreted by metastasis-associated macrophages to promote pancreatic cancer metastasis. Granulin activates hepatic stellate cells, which secrete periostin, thereby resulting in a fibrotic, pro-metastatic liver milieu.

Stark spectroscopy of molecules in liquid solutions was once challenging due to orientation effects, solved by freezing but limiting ambient studies. Now, THz Stark spectroscopy with intense terahertz pulses enables dynamic analysis of molecules in both non-polar and polar solvents at any temperature, advancing conventional methods.

Common bean has two distinct domestication centers in Mesoamerica and in the Andes. The authors show that the Andean is the first gene pool successfully introduced in Europe and identify signature of pervasive introgression among gene pools and of selection for flowering underlying adaptation.

High-elevation meteorological observations and reanalysis data indicate local cooling and drying near Himalayan glaciers due to enhanced katabatic winds in response to global warming.

The restructuring of carbon-based supports under reaction conditions limits catalyst stability for vinyl chloride synthesis. Here, the authors report that hydrogen chloride generates defect sites on carbon nitride supports, promoting acetylene polymerization and accelerating catalyst deactivation.

Nonreciprocal optical elements mostly rely on magnetic fields to break time-reversal symmetry, an approach that is difficult to integrate on-chip. Here, Ruesink et al. describe and demonstrate 4-port circulation at telecom wavelengths using a magnetic-field-free optomechanical resonator.

SARS-CoV-2 infection of expecting mothers has been reported. Here the authors profile the peripheral blood from 14 pregnant women with asymptomatic or mild SARS-CoV-2 infection to find grossly normal immune cell composition but heterogenous induction of pro-inflammatory cytokines, thereby implicating possible therapeutic targets for virus-induced damages during pregnancy.

Understanding which patients will respond to FOLFIRINOX therapy is important for clinical outcome. Here, the authors show that the MIR1307 is increased pancreatic cancer cell lines and inhibition of the microRNA sensitises cells to treatment.’ stratifying patients to achieve the best clinical outcome. Here, the authors show that the MIR1307 is increased in a subgroup of human pancreatic cancers and inhibition of the microRNA in in vitro and in vivo models of pancreatic cancer sensitises cells to treatment.

Nephropathic cystinosis is a lysosomal storage disease characterized by proximal tubular cell dysfunction. Here Festa and colleagues show that these lysosomal alterations lead to defective autophagic clearance of mitochondria and increased oxidative stress that, in turn, activates the transcription factor ZONAB leading to impaired cell differentiation.

The field of cellular agriculture has relied on 3D bioprinting for the generation of sophisticated products. Here, the authors employ chaotic bioprinting to create plant and animal cell-based hybrid noodles, thereby opening avenues to produce complex culinary designs and to explore diverse nutritional alternatives.

An emerging research area in AI is developing multi-agent capabilities with collections of interacting AI systems. Andrea Soltoggio and colleagues develop a vision for combining such approaches with current edge computing technology and lifelong learning advances. The envisioned network of AI agents could quickly learn new tasks in open-ended applications, with individual AI agents independently learning and contributing to and benefiting from collective knowledge.

Exploiting Willis coupling in acoustic metamaterials with designed geometrical asymmetries opens up new opportunities related to sound control and manipulation. Here, the authors report a dual form of Willis coupling in geometrically symmetric acoustic scatterers.

The authors introduce a new spectroscopic technique for studying Higgs modes in superconductors and apply it to a cuprate superconductor. The method involves a soft quench of the Mexican-Hat potential, populating Higgs modes of different symmetries, which are then probed by non equilibrium anti-Stokes Raman scattering.

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

Here, the authors introduce the concept of nanocscale lasers based on a tightly confined anapole mode. Using first-principle calculations they show that the superposition of internal modes can generate radiation-less states that are scattering free, potentially overcoming the limitations of conventional nanolasers.

The complexity of epithelial cell states in the fibrotic niche in the context of chronic kidney disease remains incompletely understood. Here the authors integrate snRNA and ATAC-seq with high-plex single-cell molecular imaging to generate a spatially-revolved multiomic atlas of human kidney disease.

Scarfò, Randolph et al. perform transcriptomic analysis of 28- to 32-day human embryos and identify CD32 as a marker of haemogenic endothelial cells (HECs), thus providing a strategy to isolate HECs from human embryos and pluripotent stem cell cultures.

Cold-sensitive engrams contribute to learned thermoregulation in mice that are returned to an environment in which they previously experienced a cold challenge, through a network formed between the hippocampus and hypothalamus that enables the recall of cold-related memories.

Nonreciprocal components are widely used in optical circuits but the magneto-optic effects they are based on pose difficulties for on-chip integration. Here, Ruesink et al. propose an optomechanical scheme to break reciprocity without the need for magnetic fields.

Metallic nanoantennas can enhance and confine electromagnetic fields, however, localized heating hinders many applications. Here, Caldarola et al.demonstrate both high near-field enhancement and ultra-low heat conversion in the visible-near infrared region using silicon dimer nanoantennas with 20 nm gaps.

A superconducting transition is used to switch a single molecule magnet from a blocked magnetization state to a resonant quantum tunnelling regime

This paper describes the ‘4DN Data Portal’ that hosts data generated by the 4D Nucleome network, including Hi-C and other chromatin conformation capture assays, as well as various sequencing-based and imaging-based assays. Raw data have been uniformly processed to increase comparability and the portal is implemented with visualization tools to browse the data without download.

Hyperbolic phonon polaritons that exhibit long-distance, ray-like propagation and oblique wavefronts are described at the surface of an anisotropic bulk crystal.

RMC-7977, a multi-selective RAS(ON) inhibitor, exhibits potent tumour-selective activity in multiple pre-clinical models of pancreatic ductal adenocarcinoma through a combination of pharmacology and oncogene dependence.

Hervé, Scelfo et al. show that chromosome mis-segregation induces mTORC2- and ATR-mediated p53 activation through a mechanosensitive checkpoint at the nuclear envelope triggered by altered heterochromatin content and increased nuclear membrane tension.

In twisted bilayer graphene, the moiré potential, strong electron–electron interactions and a magnetic field conspire to split the flat band into topologically non-trivial subbands.

Amgalan et al. identify BAX as a therapeutic target to prevent chemotherapy-induced cardiotoxicity without affecting the antitumor properties of doxorubicin.

Chaos causes interacting particles to rapidly thermalize and lose memory of their past. Here, the authors show that, despite thermalization, genuine quantum scarring can imprint structure and long-lived memory effects in the many-body wavefunction.

The authors used a state-of-the-science ensemble ocean reconstruction to analyze ocean heat content evolution over the last 62 years, focusing on the analysis of warming acceleration and the main sources of its uncertainty.

Osteosarcomas (OS) are aggressive bone tumors which have no actionable recurrent driver mutations. Here the authors identify aberrant expression of EZHIP in a subset of OS patients as an oncogenic driver, which exhibits vulnerability to epigenetic therapies.

Analysis of behaviour, physiology, anatomy and connectomics in Drosophila shows how direction-specific visual information is transformed onto downstream premotor networks and converted into appropriate motor responses.

A diverse, multidisciplinary panel of 386 experts in COVID-19 response from 112 countries provides health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end.

Scanning tunnelling microscopy imaging of the correlated phases of magic-angle twisted trilayer graphene shows marked signatures of interaction-driven spatial symmetry breaking.

Nonlinear optical computations have been essential yet challenging for developing optical neural networks with appreciable expressivity. In this paper, light scattering is combined with optical nonlinearity to empower a high-performance, large-scale nonlinear photonic neural system.