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Animals moving in groups are expected to differ from their many-body counterparts in equilibrium. A method based on maximum entropy shows that the interactions in starling flocks rearrange slowly enough to permit an equilibrium description locally.

Malignant cells with mesenchymal features display increased chromatin accessibility, particularly in the pericentromeric and centromeric regions, in turn resulting in delayed mitosis and catastrophic cell division.

After expression of the PML–RAR oncogene in haematopoietic stem cells, p21 is necessary to limit cell cycle progression and thus limit the accumulation of DNA damage which would otherwise limit the self-renewal of leukaemic stem cells and prevent the development of leukaemia

Multiple myeloma (MM) cancer cells can develop different resistance mechanisms to therapies inducing DNA-damage. Here, the authors show that the mitochondrial DNA repair protein DNA2 promotes MM cells survival after DNA damage-induced metabolic reprogramming.

For the development and application of quantum technologies, devices capable of implementing more than two-photon processes are vital. Towards this aim, Spagnolo et al.build a three-port beam splitter and demonstrate mutual interference between the three photons.

Primary biliary cirrhosis is an autoimmune liver disease with poor therapeutic options. Here Cordell et al. a perform meta-analysis of European genome-wide association studies identifying six novel risk loci and a number of potential therapeutic pathways.

Mignogna et al. analysed item nonresponse behaviour across 109 questionnaire items from 360,628 individuals in the UK Biobank using phenotypic and genetic data. This can inform our understanding of how item nonresponse might lead to bias in genetic studies more generally.

Analysis of earthquakes from the last two millennia indicate two potential supercycles along the East Anatolian Fault. Within each supercycle, seismic ruptures originated in the northeast and progressively spread southwestward with an increasing number of earthquakes.

Epigenetic programming of T cells in solid tumours from a functional to a dysfunctional state occurs in two phases, and only the first phase is reversible.

The clinical implications of molecular heterogeneity in HER2-positive breast cancer remain to be explored. Here, the authors investigate the transcriptomic landscape of HER2-positive breast cancer patients receiving adjuvant trastuzumab in the ALTTO clinical trial and identify five distinct molecular subtypes.

The terahertz response of topological insulator surface states, in which relativistic electrons are protected from backscattering, possesses potential optic and plasmonic applications. Here, the authors demonstrate a nonlinear absorption response of Bi₂Se₃to terahertz electric fields.

High-performance and low-cost indicators are important in food and cosmetics industry but market uptake is low due to several challenges such as toxicity, cost and unclear reading. Here, the authors report on optically-programmed, non-colorimetric indicators based on nanotextured organic non-wovens, encoded by controlling their cross-linking degree.

In the non-randomized phase 3b/4 DESTINY-Breast12 study, trastuzumab deruxtecan (T-DXd) treatment of patients with HER2⁺ advanced breast cancer and active or stable brain metastases showed consistent intracranial activity and systemic efficacy of T-DXd.

The contribution of genetic factors to the tumour immune microenvironment (TIME) remains to be investigated. Here, the authors suggest the role of TIME eQTLs for target genes involved in reversing immune suppressive features.

Swarms and statistical physics seem like natural bedfellows, but concepts like scaling are yet to prove directly applicable to insect group dynamics. A study of midges suggests they are, and that they may give rise to a new universality class.

Cancer cells can be dependent on mitochondrial respiration to survive. Here, in pancreatic cancer cells, the authors show that monounsaturated fatty acids-linked ether lipids maintain mitochondrial redox homeostasis and modulate sensitivity to inhibition to electron transport chain complex I.

Production of pearl millet is impacted by the root parasitic weed Striga hermonthica. Here, the authors assemble the genomes of resistant and susceptible lines of pearl millet and identify a critical gene CARLACTONOIC ACID METHYLTRANSFERASE1b (CLAMT1b) in determining Striga resistance.

Halbrook et al. report two metabolic subgroups of pancreatic ductal adenocarcinoma cells defined by differential integrated stress response and asparagine production that permit symbiosis and phenformin resistance.

Here the authors show that stronger immune selection and immune editing in females and younger patients lead to the accumulation of poorly presented driver mutations in tumors. These results may explain why young and female patients are characterized by lower response rates to immune checkpoint blockade therapies.

Which combination of current genome sequencing and assembly approaches results in high-quality, complete diploid genome assemblies is determined.

The association between obesity and breast cancer biology remains understudied in humans. Here, using a large retrospective data collection, the authors identify obesity associated changes in the genomic, transcriptomic profile, and the tumor microenvironment of primary untreated breast tumors.

Using genetically engineered models, Genovese and colleagues study patterns of convergent evolution in renal cancer, and pinpoint dysregulation of interferon signaling as a means of adaptation to chromosomal instability in metastatic progression.

How do flocks of birds remain cohesive while dodging predators? A study tracking up to 400 starlings reveals that information propagates in a linear fashion and with no attenuation, meaning that the language of phase transitions in correlated materials can be used to describe flocking behaviour.

Multi-modal analysis of genomically unstable ovarian tumours characterizes the contribution of anatomical sites and mutational processes to evolutionary phenotypic divergence and immune resistance mechanisms.

Non-canonical transcripts containing LINE1 transposable elements maintain naive CD4⁺ T cell quiescence and interfere with gene expression in cis. LINE1-containing transcripts are downregulated upon T cell activation.

Total mRNA expression in cancer cells is a marker for disease progression and death.

Mott metal-insulator transition in real materials is characterized by complex lattice and electron dynamics involving multiple length and time scales. Here, by combining time-resolved experimental probe and coarse-grained modelling, the authors elucidate the nanoscale dynamics across the Mott transition in V₂O₃.

KRAS mutations are a driver event of pancreatic ductal adenocarcinoma; here, a subpopulation of dormant tumour cells, relying on oxidative phosphorylation for survival, is shown to be responsible for tumour relapse after treatment targeting the KRAS pathway.

Arginine methylation by PRMTs is dysregulated in cancer. Here, the authors use functional genomics screens and identify PRMT1 as a vulnerability in pancreatic ductal adenocarcinoma, and further show that PRMT1 regulates RNA metabolism and coordinates expression of genes in cell cycle progression, maintaining genomic stability and tumour growth.

A population of β-cell-specific autoimmune stem-like CD8 T cells initiates and sustains β-cell destruction and disease in a mouse model of type 1 diabetes.

Glucocorticoids prescribed to limit inflammation, have significant adverse effects. Here the authors show that co-administration of AZD4017 with prednisolone in men is a potential strategy to limit adverse glucocorticoid effects.

It is unclear if genetic alterations in endocytic proteins play a causal role in high incidence human cancers. Here, the authors report the oncogenic role of Epsin3 (EPN3) in breast cancer, and show EPN3 to drive tumorigenesis through induction of a partial epithelial mesenchymal transition state and a TGFβ-dependent regulatory loop that promotes cellular plasticity and invasive behaviour.

The I-BAR protein IRSp53 senses membrane curvature but its physiological role is unclear. Here, the authors show that during early lumen morphogenesis, IRSp53 controls the shape of the apical plasma membrane and polarized trafficking and ensures the correct epithelial tubular architecture and if deleted, affects renal tubules morphogenesis in various organisms.

Titanocenes hold promise in biomedical research, but their stability and functionalization challenges hinder broader use. Here, the authors introduce a novel functionalization strategy using titanium protecting groups, enabling diverse modifications and advanced cellular imaging.

Constructive interference is observed in the inelastically backscattered Raman radiation from nanostructured media. The effect is studied at a macroscopic scale and is explained in the context of Rayleigh–Raman random walks inside strongly scattering materials.

SH2 domains are challenging to target using small molecules. Here, the authors develop phosphotyrosine-based covalent ligands of the E3 ligase SOCS2 using structure-based design. A pro-drug approach yields cell active inhibitors that block SOCS2 substrate recruitment.