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Via high-throughput imaging and tracking over 140 million single mycobacteria, the authors show that drug- and strain-specific killing predict treatment outcomes, with potential to improve drug development and personalized therapy.

The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance.

Domain walls in ferroelectrics can lead to phenomena different from the bulk. Here the authors achieve polarization control of charged domain walls in improper ferroelectrics by magnetic fields that convert neutral into charged domain walls.

Mechanical deformations in graphene have been shown to be associated with ‘fictitious’ magnetic fields. Theoretical work now suggests that these fields can give rise to an analogue of the Aharonov–Bohm effect, a phenomenon that might be used to sensitively detect small deformations of the graphene sheet.

A combination of nonlinear optical experiments, piezoresponse force microscopy and Monte Carlo simulations resolves the correlation between polarization, topology and temperature for the hexagonal manganite YMnO₃—a persistent ferroelectrics puzzle.

Phylogenomic analysis of 7,923 angiosperm species using a standardized set of 353 nuclear genes produced an angiosperm tree of life dated with 200 fossil calibrations, providing key insights into evolutionary relationships and diversification.

When a system is driven across a second-order phase transition, defects can form because it cannot respond quickly enough to the new conditions. The Kibble–Zurek mechanism explains this physics, and has now been invoked for Ising-type domains.

Immunological stressors are linked to the transformation of preleukemic B cells to B-cell acute lymphoblastic leukemia. Here the authors show a dysregulation of innate immune signaling in preleukemic precursor B cells and link to the development of B-cell acute lymphoblastic leukemia in a murine model.

Inventory data from more than 1 million trees across African, Amazonian and Southeast Asian tropical forests suggests that, despite their high diversity, just 1,053 species, representing a consistent ~2.2% of tropical tree species in each region, constitute half of Earth’s 800 billion tropical trees.

Circulating memory cells include central memory T cells retaining the ability to enter the lymph nodes whereas tissue resident memory cells are confined to the parenchymal tissues. Here the authors explore the interplay between the two T-cell types and show that both cooperate in anti-tumour immunity.

Genotype and exome sequencing of 150,000 participants and whole-genome sequencing of 9,950 selected individuals recruited into the Mexico City Prospective Study constitute a valuable, publicly available resource of non-European sequencing data.

Insertion of light elements in intermetallics has been explored to synthesize functional materials. Here the authors report topotactic intercalation of fluorine atoms into intermetallics using a perfluorocarbon reactant with covalent C-F bonds to obtain quantum materials.

The phenomenology of multiferroic quantum criticality, where both ferroelectric and magnetic order parameters are tuned by quantum fluctuations, is drawn out. Non-thermal tuning parameters such as alloying and strain are explored and material realizations proposed.

Electrode–domain wall junctions in ferroelectric ErMnO₃ act as nanoscale diodes.

Genetic factors that cause cardiac angiosarcoma are unknown. Calveteet al. show that a missense mutation in protection of telomeres1 (POT1) gene causes cardiac angiosarcoma by affecting the POT1 function and, consequently, telomere length and stability.

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Analysis of 2,170 SARS-CoV-2 sequences from the first wave of the COVID-19 epidemic in Spain provides insights into transmission patterns and the effects of lockdown on the emergence of new variants.

The ATLAS Collaboration reports the observation of the electroweak production of two jets and a Z-boson pair. This process is related to vector-boson scattering and allows the nature of electroweak symmetry breaking to be probed.

The ATLAS Collaboration reports a measurement of the ratio of the decay rates of W bosons to τ leptons and muons, in agreement with universal lepton couplings as postulated in the standard model of particle physics.

The ATLAS experiment at the Large Hadron Collider reports a search for charged-lepton-flavour violation in decays of Z bosons into a τ lepton and an electron or muon of opposite charge.

Ten years after the discovery of the Higgs boson, the ATLAS  experiment at CERN probes its kinematic properties with a significantly larger dataset from 2015–2018 and provides further insights on its interaction with other known particles.

Analysis of the spread of the 20E (EU1) variant of SARS-CoV-2 through Europe suggests that international travel and insufficient containment, rather than increased transmissibility, led to a resurgence of infections.

Ferroelectrics-based materials can display a negative capacitance (NC) effect, providing an opportunity to implement NC in electronic circuits to improve their performance. In this Review, the authors discuss static and transient NC responses in ferroelectrics and highlight proof-of-concept experiments and possibilities for device implementation.

Phytophthora infestans is a fungus-like eukaryote and the most destructive pathogen of potato, with current annual worldwide potato crop losses due to late blight estimated at $6.7 billion. Here, the sequence of the P. infestans genome is reported. Comparison with two other Phytophthora genomes showed rapid turnover and extensive expansion of certain secreted disease effector proteins, probably explaining the rapid adaptability of the pathogen to host plants.

Observations and modelling of an optical transient counterpart to a gravitational-wave event and γ-ray burst reveal that neutron-star mergers produce gravitational waves and radioactively powered kilonovae, and are a source of heavy elements.

Using 13 functional traits we characterize the Amazonian trees and the communities they form. Amazonian tree communities are distributed along a fast-slow-spectrum. This results in clear differences in traits among these forests, as well as their biomass and biomass productivity.

Tree species turnover across Amazonian forests unveils sharp floristic transitional zones, that are linked with changes in soil fertility and climate.