PEGylation, the covalent attachment of one or more poly(ethylene glycol) (PEG) units to a therapeutic, is commonly used in the pharmaceutical industry, but the dispersity of PEGylation agents results in batch-to-batch variations and analytical limitations. Here, the authors present an approach to overcome these limitations by manufacturing a defined molecular weight, dispersity-free, 5 kDa methoxy PEG-succinimidyl propionate (mPEG-SP5135) using Nanostar Sieving.
- Maria J. Burggraef
- Adam Oxley
- Andrew G. Livingston