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Author Correction: Mitochondrial NADPH fuels mitochondrial fatty acid synthesis and lipoylation to power oxidative metabolism

Dohun Kim
Rushendhiran Kesavan
Gerta Hoxhaj
Amendments and Corrections22 May 2025
Nature Cell Biology

Volume: 27, P: 1200
PRMT5 is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer

CDK4/6 inhibitors have improved outcomes for patients with ER+ breast cancer, however, those with loss of RB1 function often fail to respond. Here, the authors identify a vulnerability of ER + /RB1- breast cancer on PRMT5 and via dual blockade of ER and PRMT5 therapeutically target this in patient-derived xenograft models.

Chang-Ching Lin
Tsung-Cheng Chang
Carlos L. Arteaga
ResearchOpen Access13 Mar 2024
Nature Communications

Volume: 15, P: 1-16
Mitochondrial NADPH fuels mitochondrial fatty acid synthesis and lipoylation to power oxidative metabolism

Kim et al. show that NAD⁺ kinase 2 serves as a source of mitochondrial NADPH to support mitochondrial fatty acid synthesis, protein lipoylation and mitochondrial oxidative metabolism.

Dohun Kim
Rushendhiran Kesavan
Gerta Hoxhaj
Research21 Apr 2025
Nature Cell Biology

Volume: 27, P: 790-800
Structural basis for Retriever-SNX17 assembly and endosomal sorting

Endosomal recycling relies on SNX17 to transport membrane proteins via Retriever. Here, authors reveal the mechanisms of SNX17 autoinhibition and its interaction with Retriever, uncovering a broader family of factors with similar binding strategies.

Amika Singla
Daniel J. Boesch
Baoyu Chen
ResearchOpen Access25 Nov 2024
Nature Communications

Volume: 15, P: 1-18
Tryptophan fuels MYC-dependent liver tumorigenesis through indole 3-pyruvate synthesis

Amino acids availability is normally a limitation for protein synthesis and can determine cancer progression and therapy response. Here, the authors show that MYC-associated cancer has a dependency on tryptophan not because of translation regulation, but Indole 3-Pyruvate synthesis.

Niranjan Venkateswaran
Roy Garcia
Maralice Conacci-Sorrell
ResearchOpen Access20 May 2024
Nature Communications

Volume: 15, P: 1-17
Structural polymorphism of amyloid fibrils in ATTR amyloidosis revealed by cryo-electron microscopy

In this work, the authors report Cryo-EM imaging revealing diversity in amyloid fibril structures among ATTR patients with the same genetic mutation I84S. Further study is warranted to grasp the implications in ATTR amyloidosis pathology.

Binh An Nguyen
Virender Singh
Lorena Saelices
ResearchOpen Access17 Jan 2024
Nature Communications

Volume: 15, P: 1-12
CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site

Here the authors identify SUZ12 as a cellular substate of casein kinase 2 (CK2), and show this phosphorylation changes the active site structure of Polycomb repressive complex 2 (PRC2) and promotes PRC2 function in cell identity maintenance during stem cell differentiation.

Lihu Gong
Xiuli Liu
Xin Liu
ResearchOpen Access09 Nov 2022
Nature Communications

Volume: 13, P: 1-15
Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases

Malladi and colleagues show that inhibiting DRP1 limits mitochondrial plasticity, resulting in increased mitochondrial fusion, impaired fatty acid oxidation and reduced metastasis formation in breast cancer models.

Pravat Kumar Parida
Mauricio Marquez-Palencia
Srinivas Malladi
Research29 May 2023
Nature Cancer

Volume: 4, P: 893-907
Endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle

Estrogen has anti-diabetic effects via estrogen receptor alpha (ERα). Here, authors show that via coupled nuclear and non-nuclear actions, ERα in endothelial cells promotes insulin transport to skeletal muscle to foster normal glucose homeostasis.

Anastasia Sacharidou
Ken Chambliss
Philip W. Shaul
ResearchOpen Access17 Aug 2023
Nature Communications

Volume: 14, P: 1-15
Fucosylation of glycoproteins and glycolipids: opposing roles in cholera intoxication

Fucosylation of host glycoproteins is revealed to sensitize cells to cholera intoxication while fucosylation of host glycolipids is protective. The glycosyltransferases encoded by B3GALT5 and B3GNT5 are identified as key regulators of this phenomenon.

Atossa C. Ghorashi
Andrew Boucher
Jennifer J. Kohler
Research16 Oct 2024
Nature Chemical Biology

Volume: 21, P: 555-566
Discovery of tumor-specific irreversible inhibitors of stearoyl CoA desaturase

Two chemical series, oxalamides and benozothiazoles, produced toxicity in particular lung cancer cells. These compounds were metabolized in these sensitive cells by the cytochrome P450 enzyme CYP4F11 into potent inhibitors of stearoyl CoA desaturase.

Panayotis C Theodoropoulos
Stephen S Gonzales
Deepak Nijhawan
Research01 Feb 2016
Nature Chemical Biology

Volume: 12, P: 218-225
Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis

Cryo-EM analysis of fibrils from four cardiomyopathic ATTRwt amyloidosis patients reveals identical structures with minimal variability. This finding contributes to the understanding of ATTR amyloidosis biopathology.

Binh An Nguyen
Virender Singh
Lorena Saelices
ResearchOpen Access27 Jul 2024
Communications Biology

Volume: 7, P: 1-10
UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance

Carla Rodriguez Tirado
Choushi Wang
Ping Mu
ResearchOpen Access29 Nov 2023
Oncogene

Volume: 43, P: 265-280

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