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Showing 1–7 of 7 results
Advanced filters: Author: Andrew M. Leidal Clear advanced filters

  • In this Review, Leidal et al. discuss the role and regulation of autophagy in aging. They cover how autophagy promotes longevity and restricts cellular damage, and discuss autophagy modulators for the potential treatment of age-related diseases.

    • Andrew M. Leidal
    • Beth Levine
    • Jayanta Debnath
    Reviews
    Nature Cell Biology
    Volume: 20, P: 1338-1348

  • In the absence of progranulin, microglia enter a disease-specific state that causes endolysosomal dysfunction and neurodegeneration, and these microglia promote TDP-43 granule formation, nuclear pore defects and cell death specifically in excitatory neurons via the complement activation pathway.

    • Jiasheng Zhang
    • Dmitry Velmeshev
    • Eric J. Huang
    Research
    Nature
    Volume: 588, P: 459-465

  • Computational design enables the generation of a chimeric construct of the RAS exchange factor SOS that is specifically activated by a small molecule. The expression of this construct in different cell types reveals distinct phosphorylation kinetics.

    • John C Rose
    • Po-Ssu Huang
    • Dustin J Maly
    Research
    Nature Chemical Biology
    Volume: 13, P: 119-126

  • Goldsmith et al. employ ribosome profiling to dissect how deletion of the essential autophagy component Atg12 impacts mRNA translation. They detect changes in the translation of mRNAs involved in DNA repair, centrosome clustering and cell cycle control and specifically focus on how loss of autophagy causes reduced production of BRCA2 and increased DNA damage.

    • Juliet Goldsmith
    • Timothy Marsh
    • Jayanta Debnath
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-17