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Radiation therapy results in preferential tumor antigen-specific lymphodepletion in head and neck cancer

Combining radiation therapy (RT) with immunotherapy has had limited therapeutic benefits in the treatment of head and neck cancer (HNSCC). Here, the authors present a multi-omics analysis of patient biopsies pre- and post- hypofractionated RT and uncover RT-mediated depletion of tumor-reactive CD8+ T cells as the underlying cause of immunologic radioresistance in HNSCC.

Joseph Zenga
Musaddiq J. Awan
Heather A. Himburg
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-20
The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis

Cancer-associated fibroblasts (CAFs) are the main component of the stroma in pancreatic cancer, but their tissue of origin remains to be defined. Here the authors perform lineage tracing and single cell RNA sequencing in mice and suggest the splanchnic mesenchyme as the tissue of origin for CAFs.

Lu Han
Yongxia Wu
Gustavo Leone
ResearchOpen Access03 Jan 2023
Nature Communications

Volume: 14, P: 1-12
Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

Pancreatic ductal adenocarcinoma (PDAC) is a complex disease and its underlying epigenomic heterogeneity is not fully understood. Here, the authors utilize patient-derived PDAC xenografts to define the epigenomic landscape of PDAC, highlighting chromatin states linked to differing disease aggressiveness and survival.

Gwen Lomberk
Yuna Blum
Raul Urrutia
ResearchOpen Access17 May 2018
Nature Communications

Volume: 9, P: 1-10
Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway

Seungmae Seo
Angela Mathison
Raul Urrutia
ResearchOpen Access10 Oct 2018
Scientific Reports

Volume: 8, P: 1-13

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Radiation therapy results in preferential tumor antigen-specific lymphodepletion in head and neck cancer

The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis

Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway

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