López-González et al study the fMRI brain dynamics and their underlying mechanism from patients that suffered brain injuries leading to a disorder of consciousness as well as from healthy subjects undergoing propofol-induced sedation. They show that pathological and pharmacological low-level states of consciousness display disrupted synchronization patterns, higher constraint to the anatomy and a loss of heterogeneity and stability in the structural hubs compared to conscious states.
- Ane López-González
- Rajanikant Panda
- Gustavo Deco