Search

There is a lack of effective therapies for patients with non-V600E BRAF mutant cancer. Here, the authors report limited response in a phase II trial investigating the combination of binimetinib (MEK inhibitor) and encorafenib (BRAF inhibitor) for the treatment of non-V600E BRAF mutant cancer and subsequently investigate resistance mechanisms and combination therapeutic strategies in patient-derived models.

A study using English electronic health records from millions of people with atopic eczema provides an evidence resource covering the full spectrum of associated comorbidity, providing a big picture overview as well as results for each individual outcome.

Fungal parasites infect key nitrogen-fixing cyanobacteria during Baltic Sea blooms, drawing on carbon and nitrogen reserves. Here, authors find up to a fifth of newly fixed nitrogen is diverted to fungi in the cyanobacterium Dolichospermum, altering the fate of new nitrogen and trophic transfer.

A platform using matched patient-derived lung tumouroids and healthy lung organoids enables accurate examination of patient responses to CAR T therapy and offers a faithful framework for improved CAR T design.

Irregular terrains challenge users of classic prosthetic feet. Here, the authors introduce an adaptive prosthetic foot that equalizes ground contact pressure and reduces compensatory strategies and gait asymmetries compared with a traditional carbon fibre foot.

Systems of electron spins in nuclear-spin-rich hosts are gaining attention for quantum memory applications. Using spin ensemble studies, the authors propose transition metal ions in halide double perovskites as promising candidates, featuring long electron spin coherence and deterministic nuclear spin control.

deepmriprep leverages neural networks to enable voxel-based morphometry preprocessing of MRI data that is 37× faster than existing methods while achieving comparable accuracy in segmentation, registration and final statistical maps across large datasets.

A streamlined blood test using mass spectrometry improves measurement of amyloid-β for early Alzheimer’s disease diagnosis, requiring less sample volume and reagents while maintaining high accuracy, sensitivity and strong agreement with brain imaging.

The IKKα kinase was previously reported to promote metastasis. Here, the authors reveal that loss of IKKα function promotes colorectal cancer liver metastasis by expanding a CDH17⁺/CLDN2⁺ epithelial subpopulation characterized by tight junction stabilization and collective migration.

How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.

Cardiac ryanodine receptors (RyR2) are critical for heart contraction. Here, the authors use 3D MINFLUX microscopy to image receptor subunits and RyR2 orientation with nanometre resolution, thereby providing a molecular view of the organisation and clustering of these cardiac muscle receptors.

Understanding biodiversity loss and achieving global commitments requires effective biodiversity monitoring. This Roadmap outlines the necessary steps to achieve a transnational European Biodiversity Observation Network built around Essential Biodiversity Variables, combining targeted sensing methods, spatial design, data sharing, data integration and modelling workflows, and coordinated governance to deliver policy-ready insights.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

The notion that catalysts are static entities that barely change under operation is still prevalent although it is often not true. Here, a range of operando and in situ techniques reveals the dynamic nature of Co₃O₄ during the oxidation of 2-propanol to acetone, unveiling a network of interconnected solid-state processes, such as exsolution, diffusion or void formation, that govern the catalytic performance.

Identifying hippocampal ripples in humans is challenged by epileptic activity and coarse sampling. By comparing high resolution recordings in rodents and limited sampling in humans, the authors identify key ripple features and introduce a pipeline for more accurate ripple detection.

The predicted increase in frequency of droughts and rising temperatures in Europe will lead core populations of a temperate plant to an evolutionary dead-end unless they acquire genetic alleles that are present only in extreme edge Mediterranean, Scandinavian, or Siberian populations.

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

Lucerastat was well-tolerated, but did not reduce neuropathic pain, abdominal pain, or diarrhea compared with placebo. Lucerastat reduced biomarkers of Fabry Disease at 6 months, and these reductions were maintained at the 18-month interim analysis.

Hepatocyte organoids derived directly from human tissue enable long-term hepatocyte expansion and can be combined with portal mesenchyme and cholangiocyte organoids to form a donor-specific periportal liver assembloid system.

Möhring et al. assess the expected effects of a global transformation of agricultural pest management. They find positive contributions to multiple sustainability challenges, assess drivers and discuss necessary steps for a transformation.

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

A randomized field study in rural western Kenya, a region most vulnerable to the health impacts of climate change, found that modifying houses with cool-roofs and vector proofing most effectively reduced indoor heat, improved thermal comfort and lowered malaria mosquito density.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

As Nature Aging celebrates its fifth anniversary, the journal asks some of the researchers who contributed to the journal early on to reflect on the past and the future of aging and age-related disease research, the impact of the field on human health now and in the future, and what challenges need to be addressed to ensure sustained progress.

Bessler et al. developed a human organoid model for H3.3K27M-altered diffuse midline glioma that recapitulates key tumor features and demonstrated its utility for modeling CAR T cell and microglia functions.

More frequent fires in the North American boreal are causing shifts from conifer to deciduous forests. This study finds that when deciduous forests burn, their carbon losses are driven by weather, but are lower than in conifer forests, potentially dampening climate–fire feedbacks.

The study shows that autophagy in fat cells protects against obesity-induced fibrosis. Autophagy limits the release of purines, a metabolic product, that signals to immune cells to initiate the fibrosis. Purines might be a potential target for reducing tissue fibrosis.

This Perspective synthesizes insight on urban experimentation and reflects on the way forward. The authors offer lessons and argue for urban experimentation as an ongoing part of governance using whole-of-systems approaches and designing infrastructures for monitoring and evaluation.

Geminin regulates DNA replication by binding CDT1 and preventing MCM helicase loading. Using a reconstituted system and structural modelling, the authors find geminin inhibits via steric clash with MCM, not by blocking the CDT1–MCM interface. Combined with CDK activity, it fully halts licensing.

GIRK channels are activated by Gβγ; quantitative aspects are debatable. Here, the authors measure interaction affinities in living cell membranes and uncover roles of Gγ prenylation and a Gβγ docking site in GIRK1 in efficient channel activation.

How landscapes are arranged affects soil pathogenic fungi worldwide. The authors reveal the global pattern and pronounced scale-dependency of landscape complexity and land-cover quantity on soil pathogenic fungal diversity.

The study reports the discovery of a persistent bow shock around a diskless magnetic accreting white dwarf, revealing a powerful energy-loss mechanism that challenges current models of accretion and compact binary evolution.

MAGPIE is a computational framework for co-registering spatially-resolved transcriptomics, metabolomics and tissue morphology for integrated downstream analysis. Case studies across lung, brain and breast reveal coordinated cross-modality molecular changes.

Burden of major disease is projected to increase in England and many other countries. Here the authors model the impact of reducing eight known risk factors for disease burden, such as BMI and smoking, between 2023-2043 in England and report that reductions in risk factors may not substantially reduce the major illness burden by 2043 due to population ageing.

Here, the authors demonstrate that intense laser pulses drive electrons across the full Brillouin zone in monolayer WS₂, producing quantum interferences that control high harmonic generation.

Single cell transcriptomics and chromatin accessibility uncover the gene networks underlying planarian cell type differentiation, revealing insights into the combinatorial logic of planarian cell fate specification.

This study shows that T cell cross-reactivity is influenced by the co-signalling molecules CD5, CD8 and CD4, and that cytotoxic T cells with a CD8→CD4 co-receptor switch show reduced cross-reactivity without reducing on-target potency.

This study demonstrates that the extracellular matrix (ECM) of the developing brain stabilizes recently born synapses. The authors identify a microglial metalloprotease that digests the ECM to increase the plasticity of these newborn synapses.

Pathogenic BRCA2 truncating variants in heterozygosis drive distinct cancer-linked mechanisms. Here the authors show that one causes PARPi sensitivity and HR loss via haploinsufficiency, while another expresses a truncated protein that rewires transcription by hijacking PCAF, reducing H4 acetylation and NF-κB activity.

Language production and comprehension are often studied as separate processes, but they are intertwined in naturalistic conversation. In this Review, Holler and Kuhlen summarize how visual signals, feedback and multi-party interactions contribute to language processing and require further study.

The authors report electrostatic actuators that use vacuum to produce strong, fast, millimeter-scale motion by employing space-compatible polymers, representing a promising, compact, and energy-dense actuation alternative for future space robots.

Here, the authors present archaeology of the Namorotukunan site in Kenya’s Turkana Basin that demonstrates adaptive shifts in hominin tool-making behaviour spanning 300,000 years and increasing environmental variability. They contextualize these findings with paleoenvironmental proxies, dating, and geological descriptions.

Jang and colleagues demonstrate that GDF3 reshapes the chromatin landscape of inflammatory adipose tissue macrophages and drives endotoxic inflammation with age. Pharmacological inhibition of the GDF3–SMAD2/3 axis alleviates endotoxemia lethality in old mice.

Growing demand for robust plasma and serum proteomics highlights the need for better standardization. Here, the authors introduce an open 211-peptide internal standard that enables consistent quantification, cross-platform alignment and clinical utility across serum and plasma studies.

Pathogenic variants in UNC13A underlie a novel neurodevelopmental syndrome, with three subtypes defined by distinct genotypes with varying clinical and functional impacts characterized in cellular and animal models.

Quantifying ecosystem dynamics is critical in the face of rapid environmental change. This study uses airborne eDNA to quantify changes in organism abundances across the tree of life and reveal a regional decline in biodiversity over three decades.

Nature Index ‘Research Leaders’ survey also finds that scientists in North America and Europe are much more likely to say they intend to leave research.

High-depth sequencing of non-cancerous tissue from patients with metastatic cancer reveals single-base mutational signatures of alcohol, smoking and cancer treatments, and reveals how exogenous factors, including cancer therapies, affect somatic cell evolution.

HCN4 channels control cardiac pacing. Here, the authors isolated a nanobody (NB5) that binds HCN4 extracellularly in an ortholog- and isoform-specific manner and promotes its activation in sinoatrial node myocytes, leading to an increase in pacemaker rhythm.