Nature Search

Stability of the marine nitrogen cycle over the past 165 million years

A 165 Myr record of N and Corg isotopes show that the N-cycle responds to feedbacks associated with productivity and the location of upwelling centers changing due to continental meander.

Linda V. Godfrey
Anne Willem Omta
Paul G. Falkowski
ResearchOpen Access09 Oct 2025
Nature Communications

Volume: 16, P: 1-13
Large-scale multi-site study shows no association between musical training and early auditory neural sound encoding

Widely cited studies have claimed that musical training is associated with enhanced neural encoding for sound at early stages of the auditory system. Results from this large-scale multisite study do not support this earlier claim.

Kelly L. Whiteford
Lucas S. Baltzell
Andrew J. Oxenham
ResearchOpen Access08 Aug 2025
Nature Communications

Volume: 16, P: 1-14
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
De novo annotation reveals transcriptomic complexity across the hexaploid wheat pan-genome

Available wheat genomes are annotated by projecting Chinese Spring gene models across the new assemblies. Here, the authors generate de novo gene annotations for the 9 wheat genomes, identify core and dispensable transcriptome, and reveal conservation and divergence of gene expression balance across homoeologous subgenomes.

Benjamen White
Thomas Lux
Anthony Hall
ResearchOpen Access06 Oct 2025
Nature Communications

Volume: 16, P: 1-15
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Potentiation of mitochondrial function by mitoDREADD-G_s reverses pharmacological and neurodegenerative cognitive impairment in mice

Activation of G_s signaling at mitochondria by mitoDREADD-G_s increases mitochondrial metabolism, leading to better memory in mouse models of dementia, directly linking brain mitochondrial deficits to cognitive symptoms of neurodegenerative diseases.

Antonio C. Pagano Zottola
Rebeca Martín-Jiménez
Etienne Hebert-Chatelain
Research11 Aug 2025
Nature Neuroscience

Volume: 28, P: 1844-1857
Machine learning in Alzheimer’s disease genetics

Here the authors apply machine learning approaches to Alzheimer’s genetics, confirm known associations and suggest novel risk loci. These methods demonstrate predictive power comparable to traditional approaches, while also offering potential new insights beyond standard genetic analyses.

Matthew Bracher-Smith
Federico Melograna
Valentina Escott-Price
ResearchOpen Access22 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Chromosome 4q DNA rearrangements associated with facioscapulohumeral muscular dystrophy

Cisca Wijmenga
Jane E. Hewitt
Rune R. Frants
Research01 Sept 1992
Nature Genetics

Volume: 2, P: 26-30
Immunological Control of Fertility in Female Mice

ANNE MCLAREN
Research08 Feb 1964
Nature

Volume: 201, P: 582-585
Requirement for Drosophila cytoplasmic tropomyosin in oskar mRNA localization

Miklós Erdélyi
Anne-Marie Michon
Anne Ephrussi
Research12 Oct 1995
Nature

Volume: 377, P: 524-527
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Biosynthesis of Cholesterol in an Insect, Silverfish (Ctenolepisma sp.)

R. B. CLAYTON
ANNE M. EDWARDS
KONRAD BLOCH
Research15 Sept 1962
Nature

Volume: 195, P: 1125-1126
Population structure of the human pseudoautosomal boundary

Nathan Ellis
Anne Taylor
Peter Good fellow
Research12 Apr 1990
Nature

Volume: 344, P: 663-665
Targeted gene editing and near-universal cDNA insertion of CYBA and CYBB as a treatment for chronic granulomatous disease

Gene editing of hematopoietic stem and progenitor cells offers promise as a curative treatment for chronic granulomatous disease (CGD). Here, the authors develop a D10A Cas9n based gene editing strategy to treat CGD with no detectable off-target activity or chromosomal translocations.

Jonas Holst Wolff
Thomas Wisbech Skov
Jacob Giehm Mikkelsen
ResearchOpen Access12 Aug 2025
Nature Communications

Volume: 16, P: 1-16
New Galactic Supernova Remnants

D. H. CLARK
J. L. CASWELL
ANNE J. GREEN
Research02 Nov 1973
Nature

Volume: 246, P: 28-30
B61 is a ligand for the ECK receptor protein-tyrosine kinase

Timothy D. Bartley
Robert W. Hunt
Gary M. Fox
Research07 Apr 1994
Nature

Volume: 368, P: 558-560
Backscattering from frost on icy satellites in the outer Solar System

Anne Verbiscer
Paul Helfenstein
Joseph Veverka
Research13 Sept 1990
Nature

Volume: 347, P: 162-164
Pharmacogenomic screening identifies and repurposes leucovorin and dyclonine as pro-oligodendrogenic compounds in brain repair

Effective treatments for myelin repair are currently lacking. Here, the authors show that two FDA-approved drugs, leucovorin and dyclonine, identified through pharmacogenomic screening, promote oligodendrocyte formation and brain repair in myelin injury models.

Jean-Baptiste Huré
Louis Foucault
Carlos Parras
ResearchOpen Access13 Nov 2024
Nature Communications

Volume: 15, P: 1-24
Transferability of European-derived Alzheimer’s disease polygenic risk scores across multiancestry populations

Polygenic risk scores for Alzheimer’s disease derived from individuals of European ancestry can show improved performance in multiancestry settings after incorporating genome-wide association summary statistics from diverse populations.

Aude Nicolas
Richard Sherva
Jean-Charles Lambert
ResearchOpen Access18 Jun 2025
Nature Genetics

Volume: 57, P: 1598-1610
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Openshaw and colleagues find myeloid inflammation and complement activation signatures in patients with long COVID who were previously hospitalized.

Felicity Liew
Claudia Efstathiou
J. Eunice Zhang
ResearchOpen Access08 Apr 2024
Nature Immunology

Volume: 25, P: 607-621
Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte—macrophage colony stimulating factor

Nicholas M. Gough
Jill Gough
Ashley R. Dunn
Research28 Jun 1984
Nature

Volume: 309, P: 763-767
Molecular and Genetic Aspects of Human Blood-group Le^b Specificity

ANNE M. S. MARR
A. S. R. DONALD
W. T. J. MORGAN
Research23 Sept 1967
Nature

Volume: 215, P: 1345-1349
Antibody Production by Leucocytes in Peripheral Blood

MAURICE LANDY
RONALD P. SANDERSON
ANNE L. JACKSON
Research26 Dec 1964
Nature

Volume: 204, P: 1320-1321
Twin Data in Support of the Lyon Hypothesis

STEVEN G. VANDENBERG
VICTOR A. McKUSICK
ANNE B. McKUSICK
Research05 May 1962
Nature

Volume: 194, P: 505-506
Molecular switches in metastasis

DNA microarrays have been used to analyse the gene-expression profiles of a variety of cancers. Now this technique has revealed several genes that are upregulated specifically in metastatic melanomas compared with their non-metastatic counterparts. One of these genes, RhoC, can induce metastasis all by itself.

Anne Ridley
News & Views01 Aug 2000
Nature

Volume: 406, P: 466-467
Translon: a single term for translated regions

Michał I. Świrski
Jack A. S. Tierney
Pavel V. Baranov
Correspondence01 Sept 2025
Nature Methods

Volume: 22, P: 2002-2006
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
DG9 boosts PMO nuclear uptake and exon skipping to restore dystrophic muscle and cardiac function

The authors show that the cell-penetrating peptide DG9 enhances PMO delivery to skeletal and cardiac muscles via multiple endocytic pathways. DG9-PMO significantly boosts dystrophin restoration and cardioprotection, addressing a key challenge in the therapy of Duchenne muscular dystrophy.

Md Nur Ahad Shah
Harry Wilton-Clark
Toshifumi Yokota
ResearchOpen Access14 May 2025
Nature Communications

Volume: 16, P: 1-16
Nine books to help shape your science career in 2025

Researchers seeking to banish workaholic behaviours, boost their pay, have more influence at work or quit academia will find plenty of advice in these books, all published this year.

Anne Gulland
Comments & Opinion09 Dec 2024
Nature

Volume: 636, P: 509-511
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of an Alzheimer’s disease polygenic risk score.

Itziar de Rojas
Sonia Moreno-Grau
Agustín Ruiz
ResearchOpen Access07 Jun 2021
Nature Communications

Volume: 12, P: 1-16
Physiological constraints to climate warming in fish follow principles of plastic floors and concrete ceilings

Understanding climatic adaptation in fish is limited by a lack of large-scale, long term acclimation studies. Here, Sandblom et al. show that fish exposed to a 5-10 °C increase in water temperature next to a nuclear power plant display contrasting upper and lower cardiorespiratory thermal compensation limits.

Erik Sandblom
Timothy D. Clark
Fredrik Jutfelt
ResearchOpen Access17 May 2016
Nature Communications

Volume: 7, P: 1-8
LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers

Co-occurring mutations in the tumor suppressor LKB1 are frequent in KRAS-mutant lung cancers. Here, the authors show that LKB1 regulates JNK-dependent stress signaling apoptotic dependencies of KRAS-mutant tumors, making LKB1-deficient cells vulnerable to MCL-1 inhibition.

Chendi Li
Mohammed Usman Syed
Aaron N. Hata
ResearchOpen Access02 May 2025
Nature Communications

Volume: 16, P: 1-16
Clinical characteristic and outcome of HHV-6 encephalitis after allogeneic hematopoietic cell transplantation: A study of Infectious Disease Working Party of EBMT

Katia Perruccio
Katherine N. Ward
Simone Cesaro
Research03 Jun 2025
Bone Marrow Transplantation

Volume: 60, P: 1243-1248
Neurovascular coupling and CO₂ interrogate distinct vascular regulations

A remerging hypothesis suggests that CO2 generated by neuronal metabolism contributes to neurovascular coupling (NVC). Here, the authors show that NVC is unaffected by the acidification of the entire arteriolar column during cerebrovascular reactivity to CO2, demonstrating that CO2 is not a mediator of NVC.

Marine Tournissac
Emmanuelle Chaigneau
Serge Charpak
ResearchOpen Access02 Sept 2024
Nature Communications

Volume: 15, P: 1-12
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

COVID-19 can be associated with neurological complications. Here the authors show that markers of brain injury, but not immune markers, are elevated in the blood of patients with COVID-19 both early and months after SARS-CoV-2 infection, particularly in those with brain dysfunction or neurological diagnoses.

Benedict D. Michael
Cordelia Dunai
David K. Menon
ResearchOpen Access22 Dec 2023
Nature Communications

Volume: 14, P: 1-15
Microarray Analysis of PBMC after Plasmodium falciparum Infection: Molecular Insights into Disease Pathogenesis

Wan-Chung(Wan-Jiung) Hu
Alan Scott
August Louis Bourgeois
ResearchOpen Access27 Apr 2011
Nature Precedings

P: 1
Similar level of polyteny in bands and interbands of Drosophila giant chromosomes

Anne Spierer
Pierre Spierer
Research12 Jan 1984
Nature

Volume: 307, P: 176-178
Genetic similarity between relatives provides evidence on the presence and history of assortative mating

Non-random mating can complicate genetic studies, but implications hinge on its history in prior generations. Here, the authors use genetic similarity between relatives to investigate which traits show evidence of recent changes in mating behavior.

Hans Fredrik Sunde
Nikolai Haahjem Eftedal
Fartein Ask Torvik
ResearchOpen Access26 Mar 2024
Nature Communications

Volume: 15, P: 1-11
The Effect of Decreased Catecholamine Transmission on ERP Indices of Selective Attention

Anne-Marie Shelley
Stanley V Catts
Nathaniel McConaghy
Research01 Mar 1997
Neuropsychopharmacology

Volume: 16, P: 202-210
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
scEpiAge: an age predictor highlighting single-cell ageing heterogeneity in mouse blood

Here, the authors generate a single-cell DNA methylation and transcriptome dataset from mouse peripheral blood samples, spanning a broad range of ages. They next develop scEpiAge, a single-cell DNA methylation age predictor.

Marc Jan Bonder
Stephen J. Clark
Ferdinand von Meyenn
ResearchOpen Access31 Aug 2024
Nature Communications

Volume: 15, P: 1-15
Chiral fluids and filaments

Chiral isotropic fluids and helical nanofilaments based on achiral, bent-core molecules have been observed

Anne Pichon
Research Highlights07 Aug 2009
Nature Chemistry

P: 1
The effect of increased salt intake on blood pressure of chimpanzees

Derek Denton
Richard Weisinger
Jean Baptiste Michel
Research01 Oct 1995
Nature Medicine

Volume: 1, P: 1009-1016
Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection

The response to infectious and inflammatory challenges differs among people but the reasons for this are poorly understood. Here the authors explore the impact of variables such as age, sex, and the capacity for controlling inflammation and maintaining immunocompetence, linking this capacity to favourable health outcomes and lifespan.

Sunil K. Ahuja
Muthu Saravanan Manoharan
Weijing He
ResearchOpen Access13 Jun 2023
Nature Communications

Volume: 14, P: 1-31
Function for Ras in sight

Anne J. Ridley
Alan Hall
News & Views06 Feb 1992
Nature

Volume: 355, P: 497-498
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in inflammatory bowel disease patients treated with infliximab and vedolizumab

Vaccination is effective in protecting from COVID-19. Here the authors report immune responses and breakthrough infections in twice-vaccinated patients receiving anti-TNF treatments for inflammatory bowel disease, and find dampened vaccine responses that implicate the need of adapted vaccination schedules for these patients.

Simeng Lin
Nicholas A. Kennedy
Jeannie Bishop
ResearchOpen Access16 Mar 2022
Nature Communications

Volume: 13, P: 1-14
Non-CG DNA methylation is a biomarker for assessing endodermal differentiation capacity in pluripotent stem cells

The methylation of non-CpG residues is a poorly understood marker of pluripotent cells, gradually lost as cells differentiate. Here the authors show non-CG methylation can be used as a marker of differentiation potential.

Lee M. Butcher
Mitsuteru Ito
Stephan Beck
ResearchOpen Access29 Jan 2016
Nature Communications

Volume: 7, P: 1-8

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