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Pivotal role of exogenous pyruvate in human natural killer cell metabolism

Kern Coquillat et al. show that NK cells rely on exogenous pyruvate import to support effector functions.

Nicolas Kern Coquillat
Louis Picq
Antoine Marçais
Research03 Jan 2025
Nature Metabolism

Volume: 7, P: 336-347
Role of PI3-kinase in Bcl-X induction and apoptosis inhibition mediated by IL-3 or IGF-1 in Baf-3 cells

Yann Leverrier
Joëlle Thomas
Jacqueline Marvel
Research12 Mar 1999
Cell Death & Differentiation

Volume: 6, P: 290-296
Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells

Natural Killer cell development is controlled by two related transcription factors, Eomes and T-bet. Authors show here that while the two factors share a large proportion of their target genes, they regulate distinct developmental processes by differing in their pattern of expression and in their associated co-factors.

Jiang Zhang
Stéphanie Le Gras
Thierry Walzer
ResearchOpen Access14 Sept 2021
Nature Communications

Volume: 12, P: 1-17
Early-onset autoimmunity associated with SOCS1 haploinsufficiency

SOCS1 is a potent suppressor of JAK-STAT signalling responses to IFNγ and γ-chain cytokines and thereby limits inflammation. Here the authors identify and characterize heterozygous SOCS1 mutations in 10 patients from 5 unrelated families with autoimmune diseases.

Jérôme Hadjadj
Carla Noemi Castro
Frédéric Rieux-Laucat
ResearchOpen Access21 Oct 2020
Nature Communications

Volume: 11, P: 1-11
Federated learning for predicting histological response to neoadjuvant chemotherapy in triple-negative breast cancer

Federated learning improves prediction of the histological response to neoadjuvant chemotherapy in patients with triple-negative breast cancer, demonstrating the feasibility of this approach for analysis of multicenter cohorts of patients with rare diseases.

Jean Ogier du Terrail
Armand Leopold
Pierre-Etienne Heudel
Research19 Jan 2023
Nature Medicine

Volume: 29, P: 135-146
Targeted MinION sequencing of transgenes

Anne-Laure Boutigny
Florent Fioriti
Mathieu Rolland
ResearchOpen Access15 Sept 2020
Scientific Reports

Volume: 10, P: 1-7
Role of IL-27 in Epstein–Barr virus infection revealed by IL-27RA deficiency

IL-27RA–IL-27 has a critical role in the immunity to EBV, and this defence is hijacked by Epstein–Barr virus to promote the expansion of infected transformed B cells

Emmanuel Martin
Sarah Winter
Sylvain Latour
Research20 Mar 2024
Nature

Volume: 628, P: 620-629
Intermittent hypoxia-induced insulin resistance is associated with alterations in white fat distribution

Laureline Poulain
Hervé Mathieu
Maurice Dematteis
ResearchOpen Access11 Sept 2017
Scientific Reports

Volume: 7, P: 1-9
Classification of GBA1 variants and their impact on Parkinson’s disease: an in silico score analysis

Aymeric Lanore
Christelle Tesson
Eva Camgrand
ResearchOpen Access02 Aug 2025
npj Parkinson's Disease

Volume: 11, P: 1-14
A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes

Here, the authors develop and characterize a mouse microbiota composed of 15 strains representative of the intestinal microbiota found in C57BL/6J specific opportunistic- and pathogen-free (C57Bl/6J SOPF) mice and derive a new standardized gnotobiotic mouse model, called GM15, which recapitulates the phenotypes of SOPF or SPF animals in different animal facilities with improved reproducibility.

Marion Darnaud
Filipe De Vadder
Andrea Tamellini
ResearchOpen Access18 Nov 2021
Nature Communications

Volume: 12, P: 1-21
Dynamic interplay of cNHEJ and MMEJ pathways of DNA double-strand break repair during embryonic development in zebrafish

Mathieu Carrara
Anne-Laure Gaillard
Guillaume Pézeron
ResearchOpen Access10 Feb 2025
Scientific Reports

Volume: 15, P: 1-15
Targeted Next Generation Sequencing to study insert stability in genetically modified plants

Anne-Laure Boutigny
Audrey Barranger
Mathieu Rolland
ResearchOpen Access19 Feb 2019
Scientific Reports

Volume: 9, P: 1-9
Association between moderated level of air pollution and fetal growth: the potential role of noise exposure

Anne-Sophie Mariet
Nadine Bernard
Catherine Quantin
ResearchOpen Access27 May 2021
Scientific Reports

Volume: 11, P: 1-11
Zeb1 represses TCR signaling, promotes the proliferation of T cell progenitors and is essential for NK1.1⁺ T cell development

Jiang Zhang
Mélanie Wencker
Thierry Walzer
Research12 May 2020
Cellular & Molecular Immunology

Volume: 18, P: 2140-2152
A framework to identify contributing genes in patients with Phelan-McDermid syndrome

Anne-Claude Tabet
Thomas Rolland
Thomas Bourgeron
ResearchOpen Access23 Oct 2017
npj Genomic Medicine

Volume: 2, P: 1-9
Short exposure to cold atmospheric plasma induces senescence in human skin fibroblasts and adipose mesenchymal stromal cells

Marion Bourdens
Yannick Jeanson
Valérie Planat-Bénard
ResearchOpen Access17 Jun 2019
Scientific Reports

Volume: 9, P: 1-15
Author Correction: A framework to identify contributing genes in patients with Phelan-McDermid syndrome

Anne-Claude Tabet
Thomas Rolland
Thomas Bourgeron
Amendments and CorrectionsOpen Access01 Jul 2019
npj Genomic Medicine

Volume: 4, P: 1
Overview and detectability of the genetic modifications in ornamental plants

Anne-Laure Boutigny
Nicolas Dohin
Mathieu Rolland
ReviewsOpen Access01 Feb 2020
Horticulture Research

Volume: 7, P: 1-12

Search

Pivotal role of exogenous pyruvate in human natural killer cell metabolism

Role of PI3-kinase in Bcl-X induction and apoptosis inhibition mediated by IL-3 or IGF-1 in Baf-3 cells

Sequential actions of EOMES and T-BET promote stepwise maturation of natural killer cells

Early-onset autoimmunity associated with SOCS1 haploinsufficiency

Federated learning for predicting histological response to neoadjuvant chemotherapy in triple-negative breast cancer

Targeted MinION sequencing of transgenes

Role of IL-27 in Epstein–Barr virus infection revealed by IL-27RA deficiency

Intermittent hypoxia-induced insulin resistance is associated with alterations in white fat distribution

Classification of GBA1 variants and their impact on Parkinson’s disease: an in silico score analysis

A standardized gnotobiotic mouse model harboring a minimal 15-member mouse gut microbiota recapitulates SOPF/SPF phenotypes

Dynamic interplay of cNHEJ and MMEJ pathways of DNA double-strand break repair during embryonic development in zebrafish

Targeted Next Generation Sequencing to study insert stability in genetically modified plants

Association between moderated level of air pollution and fetal growth: the potential role of noise exposure

Zeb1 represses TCR signaling, promotes the proliferation of T cell progenitors and is essential for NK1.1⁺ T cell development

A framework to identify contributing genes in patients with Phelan-McDermid syndrome

Short exposure to cold atmospheric plasma induces senescence in human skin fibroblasts and adipose mesenchymal stromal cells

Author Correction: A framework to identify contributing genes in patients with Phelan-McDermid syndrome

Overview and detectability of the genetic modifications in ornamental plants

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