Transcriptional regulation of the interferon-β gene (Ifnb1) in macrophages is a critical immune event. Here, Ferri et al. show that, at late phases of macrophages activation, TRIM33 bound to a distal repressor element suppresses Ifnb1transcription by preventing recruitment of CBP/p300.
- Federica Ferri
- Aude Parcelier
- Paul-Henri Romeo
