Nature Search

The global cardiovascular–liver–metabolic syndemic: epidemiology, trends and challenges

In this Review, Nicholas Chew and colleagues use epidemiological data on the cardiovascular–liver–metabolic disease syndemic to illustrate current and future projections on the burden of these diseases and their risk factors, and propose a unified framework for integrating and implementing effective multisystem interventions to tackle key components of this syndemic.

Nicholas W. S. Chew
Anurag Mehta
Laurence S. Sperling
Reviews06 Oct 2025
Nature Reviews Cardiology

P: 1-20
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Artificial intelligence uncovers carcinogenic human metabolites

Metabokiller is a novel, explainable AI-backed method for carcinogenicity prediction that leverages the biological and chemical properties associated with carcinogens.

Aayushi Mittal
Sanjay Kumar Mohanty
Gaurav Ahuja
Research11 Aug 2022
Nature Chemical Biology

Volume: 18, P: 1204-1213
Non-invasive scoring systems of liver fibrosis predict prognosis in the cohort with myocardial infarction

Esther Wong
Yiming Chen
Nicholas WS Chew
ResearchOpen Access21 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Fine-scale geospatial mapping of overweight and wasting (two components of the double burden of malnutrition) in 105 LMICs shows that overweight has increased from 5.2% in 2000 to 6.0% in children under 5 in 2017. Although overall wasting decreased over the same period, most countries are not on track to meet the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025.

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
ResearchOpen Access20 Apr 2020
Nature Medicine

Volume: 26, P: 750-759
Apolipoproteins in vascular biology and atherosclerotic disease

In this Review, Mehta and Shapiro discuss the mechanisms by which apolipoproteins regulate lipoprotein metabolism and thereby influence vascular biology and atherosclerotic disease. Advances in the understanding of apolipoprotein biology and their translation into therapeutic agents to reduce the risk of cardiovascular disease are also highlighted.

Anurag Mehta
Michael D. Shapiro
Reviews08 Oct 2021
Nature Reviews Cardiology

Volume: 19, P: 168-179
Family income and cardiovascular disease risk in American adults

Abdul Mannan Khan Minhas
Vardhmaan Jain
Anurag Mehta
ResearchOpen Access06 Jan 2023
Scientific Reports

Volume: 13, P: 1-10
Metabolomic signatures of ideal cardiovascular health in black adults

Shabatun J. Islam
Chang Liu
Charles D. Searles
ResearchOpen Access20 Jan 2024
Scientific Reports

Volume: 14, P: 1-11
Author Correction: Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017

Damaris K. Kinyoki
Jennifer M. Ross
Simon I. Hay
Amendments and CorrectionsOpen Access02 Jul 2020
Nature Medicine

Volume: 26, P: 1308
A multi-institutional real world data study from India of 3453 non-metastatic breast cancer patients undergoing upfront surgery

Dinesh Chandra Doval
Selvi Radhakrishna
Ramesh B. V. Nimmagadda
ResearchOpen Access03 Apr 2020
Scientific Reports

Volume: 10, P: 1-10
Goat lung surfactant for treatment of respiratory distress syndrome among preterm neonates: a multi-site randomized non-inferiority trial

Kajal Jain
Sushma Nangia
Ramesh Agarwal
ResearchOpen Access04 Sept 2019
Journal of Perinatology

Volume: 39, P: 3-12
Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis

Bryan Tan
Xin-Hui Pan
Yip Han Chin
Reviews31 May 2023
International Journal of Obesity

Volume: 47, P: 677-685

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