Nature Search

Single-nucleus RNA sequencing reveals a preclinical model for the most common subtype of glioblastoma

Characterization of tumour and tumour microenvironment by single-nucleus RNA sequencing reveals that the murine GL261-GSC glioblastoma model recapitulates the features of TME^Med glioblastoma, the most common subtype of human glioblastoma.

Laura García-Vicente
María Martínez-Fernández
Arantxa Tabernero
ResearchOpen Access28 Apr 2025
Communications Biology

Volume: 8, P: 1-19
Mechanisms of Disease: pathologic structural remodeling is more than adaptive hypertrophy in hypertensive heart disease

Structural remodeling of the heart is known to be related to various processes mediated by mechanical, neurohormonal and cytokine routes. Disruption in the production and breakdown of collagen fibers is a prominent mechanism in left-ventricular fibrosis. Javier Díez and colleagues discuss noninvasive diagnostic methods for such hypertrophy and possible therapeutic strategies to promote its reduction

Javier Díez
Arantxa González
Ramón Querejeta
Reviews01 Apr 2005
Nature Clinical Practice Cardiovascular Medicine

Volume: 2, P: 209-216
A cross-species proteomic map reveals neoteny of human synapse development

A study presents a cross-species proteomic map of synapse development in neocortex and reveals that the human postsynaptic density assembly develops two to three times slower than that in macaques and mice.

Li Wang
Kaifang Pang
Arnold R. Kriegstein
Research13 Sept 2023
Nature

Volume: 622, P: 112-119
Mechanisms underlying the cardiac antifibrotic effects of losartan metabolites

José Luis Miguel-Carrasco
Javier Beaumont
Susana Ravassa
ResearchOpen Access03 Feb 2017
Scientific Reports

Volume: 7, P: 1-9
The small molecule LOXL2 inhibitor SNT-5382 reduces cardiac fibrosis and achieves strong clinical target engagement

Lara Perryman
Alison Findlay
Wolfgang Jarolimek
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis

Marta Varela-Eirín
Adrián Varela-Vázquez
María D. Mayán
ResearchOpen Access05 Dec 2018
Cell Death & Disease

Volume: 9, P: 1-16
A novel treatment for heart failure targets myocardial fibrosis

A new trial suggests that pirfenidone, an approved treatment for idiopathic pulmonary fibrosis, may also reduce myocardial fibrosis in patients with heart failure who have a preserved left ventricular ejection fraction.

John G. F. Cleland
Pierpaolo Pellicori
Arantxa González
News & Views12 Aug 2021
Nature Medicine

Volume: 27, P: 1343-1344
Effects of spironolactone on exercise blood pressure in patients at increased risk of developing heart failure: report from the HOMAGE trial

Fang-Fei Wei
Pierpaolo Pellicori
Faiez Zannad
ResearchOpen Access06 Sept 2024
Hypertension Research

Volume: 47, P: 3225-3236
MicroRNA-19b is a potential biomarker of increased myocardial collagen cross-linking in patients with aortic stenosis and heart failure

Javier Beaumont
Begoña López
Arantxa González
ResearchOpen Access16 Jan 2017
Scientific Reports

Volume: 7, P: 1-10
Author Correction: MicroRNA-19b is a potential biomarker of increased myocardial collagen cross-linking in patients with aortic stenosis and heart failure

Javier Beaumont
Begoña López
Arantxa González
Amendments and CorrectionsOpen Access16 Apr 2020
Scientific Reports

Volume: 10, P: 1
Diffuse myocardial fibrosis: mechanisms, diagnosis and therapeutic approaches

In this Review, Díez and colleagues summarize the mechanisms of diffuse myocardial fibrosis in heart failure, discuss imaging techniques and circulating biomarkers to characterize the variability of this lesion in patients, and highlight the available and potential future therapeutic strategies for personalizing the prevention and reversal of diffuse myocardial fibrosis.

Begoña López
Susana Ravassa
Javier Díez
Reviews10 Feb 2021
Nature Reviews Cardiology

Volume: 18, P: 479-498
ADAMTSL3 knock-out mice develop cardiac dysfunction and dilatation with increased TGFβ signalling after pressure overload

The role of ADAMTSL3 in heart pathology and cardiac disease is investigated with Adamtsl3-deficient mice using CRISPR-Cas9 gene editing.

Karoline B. Rypdal
A. Olav Melleby
Ida G. Lunde
ResearchOpen Access20 Dec 2022
Communications Biology

Volume: 5, P: 1-15
Characterization of biventricular alterations in myocardial (reverse) remodelling in aortic banding-induced chronic pressure overload

Daniela Miranda-Silva
Patrícia Gonçalves-Rodrigues
Inês Falcão-Pires
ResearchOpen Access27 Feb 2019
Scientific Reports

Volume: 9, P: 1-14
Feasibility of treatment discontinuation in chronic myeloid leukemia in clinical practice: results from a nationwide series of 236 patients

Juan Carlos Hernández-Boluda
Arturo Pereira
Juan Luis Steegmann
ResearchOpen Access02 Dec 2018
Blood Cancer Journal

Volume: 8, P: 1-8
Cartilage intermediate layer protein 1 (CILP1): A novel mediator of cardiac extracellular matrix remodelling

Frans A. van Nieuwenhoven
Chantal Munts
Marc van Bilsen
ResearchOpen Access22 Nov 2017
Scientific Reports

Volume: 7, P: 1-9
Tear proteome analysis in ocular surface diseases using label-free LC-MS/MS and multiplexed-microarray biomarker validation

Javier Soria
Arantxa Acera
Tatiana Suárez
ResearchOpen Access12 Dec 2017
Scientific Reports

Volume: 7, P: 1-15
Human exposure to per- and polyfluoroalkyl substances and other emerging contaminants in drinking water

Dora Cserbik
Paula E. Redondo-Hasselerharm
Cintia Flores
ResearchOpen Access03 Mar 2023
npj Clean Water

Volume: 6, P: 1-10

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