Nature Search

NSD2 is a conserved driver of metastatic prostate cancer progression

Identifying cell intrinsic mechanisms promoting metastasis are necessary to develop new cancer therapeutics. Here they do cross-species computational analysis and identify nuclear receptor binding SET domain Protein 2 (NSD2) as a driver of prostate cancer metastasis.

Alvaro Aytes
Arianna Giacobbe
Cory Abate-Shen
ResearchOpen Access05 Dec 2018
Nature Communications

Volume: 9, P: 1-14
Time-resolved diffraction of shock-released SiO₂ and diaplectic glass formation

Our understanding of shock metamorphism and thus the collision of planetary bodies is limited by a dependence on ex situ analyses. Here, the authors perform in situ analysis on shocked-produced densified glass and show that estimates of impactor size based on traditional techniques are likely inflated.

A. E. Gleason
C. A. Bolme
W. L. Mao
ResearchOpen Access14 Nov 2017
Nature Communications

Volume: 8, P: 1-6
A MYC and RAS co-activation signature in localized prostate cancer drives bone metastasis and castration resistance

Using lineage tracing and molecular profiling, Abate-Shen and colleagues identify a Ras and Myc co-activation signature that predicts metastasis and castration resistance in localized prostate cancer.

Juan M. Arriaga
Sukanya Panja
Cory Abate-Shen
Research19 Oct 2020
Nature Cancer

Volume: 1, P: 1082-1096
Instrumental activities of daily living in older patients with metastatic prostate cancer: results from the meet-URO network ADHERE prospective study

Lucia Fratino
Jerry Polesel
Giuseppe Luigi Banna
ResearchOpen Access28 Feb 2024
Scientific Reports

Volume: 14, P: 1-8
Ultrafast visualization of crystallization and grain growth in shock-compressed SiO₂

Pressure- and temperature-induced phase transitions have long been studied, but little is known about the processes by which the atoms rearrange. Here, the authors presentin situmeasurements on shock compressed fused silica, revealing an amorphous to crystalline high pressure stishovite phase transition.

A. E. Gleason
C. A. Bolme
W. L. Mao
ResearchOpen Access04 Sept 2015
Nature Communications

Volume: 6, P: 1-7
Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression

Transcriptional changes during prostate cancer progression are not yet fully understood. Here, the authors integrate a transcriptomics atlas of prostate cancer and validate it with preclinical models and single-cell RNA-seq, revealing the role of EZH2 and macrophage polarisation in tumour progression.

Marco Bolis
Daniela Bossi
Jean-Philippe P. Theurillat
ResearchOpen Access02 Dec 2021
Nature Communications

Volume: 12, P: 1-15
Patient-derived xenografts and organoids model therapy response in prostate cancer

To date, patients still succumb to cancer, due to tumors not responding to therapy or ultimately acquiring resistance. Here the authors show that by exploiting patient derived organoids and a treatment-naïve patient derived xenograft, patient therapy can be personalized.

Sofia Karkampouna
Federico La Manna
Marianna Kruithof-de Julio
ResearchOpen Access18 Feb 2021
Nature Communications

Volume: 12, P: 1-13
Structural evolution of liquid silicates under conditions in Super-Earth interiors

Combining laser-driven shock compression and ultra-short X-ray pulses from LCLS, the local structure of liquid silicates was determined up to 385 GPa. Compared with molecular dynamics calculations, continuous densification of O-O and Mg-Si networks may alter melt properties and impact planetary differentiation.

Guillaume Morard
Jean-Alexis Hernandez
Alessandra Ravasio
ResearchOpen Access03 Oct 2024
Nature Communications

Volume: 15, P: 1-9
Evidence of shock-compressed stishovite above 300 GPa

Markus O. Schoelmerich
Thomas Tschentscher
Karen Appel
ResearchOpen Access23 Jun 2020
Scientific Reports

Volume: 10, P: 1-8
X-ray microscopy and talbot imaging with the matter in extreme conditions X-ray imager at LCLS

Eric Galtier
Hae Ja Lee
Bob Nagler
ResearchOpen Access04 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Calcium cytotoxicity sensitizes prostate cancer cells to standard-of-care treatments for locally advanced tumors

Alessandro Alaimo
Marco Lorenzoni
Andrea Lunardi
ResearchOpen Access07 Dec 2020
Cell Death & Disease

Volume: 11, P: 1-17
Release dynamics of nanodiamonds created by laser-driven shock-compression of polyethylene terephthalate

Ben Heuser
Armin Bergermann
Dominik Kraus
ResearchOpen Access28 May 2024
Scientific Reports

Volume: 14, P: 1-11
Single-Shot Multi-Frame Imaging of Cylindrical Shock Waves in a Multi-Layered Assembly

Leora Dresselhaus-Cooper
Joshua E. Gorfain
Keith A. Nelson
ResearchOpen Access06 Mar 2019
Scientific Reports

Volume: 9, P: 1-12

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