Nature Search

Seasonal variations of antioxidant imbalance in Cuban healthy men

J Arnaud
P Fleites
AE Favier
Research22 Jan 2001
European Journal of Clinical Nutrition

Volume: 55, P: 29-38
Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

Interaction between HIV-1 integrase and the cellular cofactor LEDGF/p75 is important for viral integration. Newly designed small molecules that block this interaction inhibit HIV replication, illustrating the potential of viral–host protein-protein interaction inhibitors.

Frauke Christ
Arnout Voet
Zeger Debyser
Research16 May 2010
Nature Chemical Biology

Volume: 6, P: 442-448
A coronavirus assembly inhibitor that targets the viral membrane protein

High-throughput screening and hit optimization have led to the development of a small molecule, CIM-834, that targets the SARS-CoV-2 membrane protein and blocks assembly of the virus.

Manon Laporte
Dirk Jochmans
Johan Neyts
ResearchOpen Access26 Mar 2025
Nature

Volume: 640, P: 514-523
The nature of soil blue carbon varies across mangrove geomorphic settings

Mangrove soil organic matter pools across different geomorphic settings vary more strongly than across all terrestrial biomes, according to soil core analysis of multiple mangrove geomorphic settings.

Marie Arnaud
Catherine E. Lovelock
Cornelia Rumpel
ResearchOpen Access09 Sept 2025
Communications Earth & Environment

Volume: 6, P: 1-10
Author Correction: Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

Kate Lawrenson
Siddhartha Kar
Simon A. Gayther
Amendments and CorrectionsOpen Access08 Sept 2025
Nature Communications

Volume: 16, P: 1-2
PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression

The integrated stress response (ISR) allows cells to restore cellular homeostasis upon a wide range of stress stimuli. Here, the authors show that PIM2 inhibition activates the ISR and promotes NOXA expression, in turn making tumour cells vulnerable to MCL1 inhibition.

Marion Haas
Sabrina Cherfa
Thierry Fest
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-20
Publisher Correction: A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction

Suzanne J. F. Kaptein
Olivia Goethals
Johan Neyts
Amendments and Corrections20 Oct 2021
Nature

Volume: 599, P: E2
Axonal RNA localization is essential for long-term memory

Axonal transcriptomes have been characterized, but their regulation and role in neuronal circuits remain unclear. Here authors uncover activity-dependent RNA localization in axons important for memory consolidation.

Bruna R. de Queiroz
Hiba Laghrissi
Florence Besse
ResearchOpen Access15 Mar 2025
Nature Communications

Volume: 16, P: 1-17
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

A region on chromosome 19p13 is associated with the risk of developing ovarian and breast cancer. Here, the authors genotyped SNPs in this region in thousands of breast and ovarian cancer patients and identified SNPs associated with three genes, which were analysed with functional studies.

Kate Lawrenson
Siddhartha Kar
Simon A. Gayther
ResearchOpen Access07 Sept 2016
Nature Communications

Volume: 7, P: 1-22
Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

JNJ-1802—a highly potent dengue virus inhibitor—blocks the NS3–NS4B interaction within the viral replication complex, and is highly effective against viral infection with DENV-1 or DENV-2 in non-human primates.

Olivia Goethals
Suzanne J. F. Kaptein
Marnix Van Loock
ResearchOpen Access15 Mar 2023
Nature

Volume: 615, P: 678-686
Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

Steve Brown and colleagues report an analysis of 20 phenotyping tests, including 413 data parameters, across 449 mutant mouse alleles. They identify widespread pleiotropy and assign putative functions to genes that lacked previous phenotypic annotation.

Martin Hrabě de Angelis
George Nicholson
Steve D M Brown
Research27 Jul 2015
Nature Genetics

Volume: 47, P: 969-978
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Breast cancer risk for BRCA1/BRCA2 mutation carriers varies depending on other genetic factors. Here, the authors perform a case-only genome-wide association study and highlight novel loci associated with breast cancer risk for BRCA1/BRCA2 mutation carriers.

Juliette Coignard
Michael Lush
Antonis C. Antoniou
ResearchOpen Access17 Feb 2021
Nature Communications

Volume: 12, P: 1-22
A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction

The small molecule JNJ-A07 interferes with the interaction between the NS3 and NS4B proteins of dengue virus and reduces the viral load in mice even when first administered at peak viraemia.

Suzanne J. F. Kaptein
Olivia Goethals
Johan Neyts
Research06 Oct 2021
Nature

Volume: 598, P: 504-509
Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Roger Milne and colleagues conduct a genome-wide association study for estrogen receptor (ER)-negative breast cancer combined with BRCA1 mutation carriers in a large cohort. They identify ten new risk variants and find high genetic correlation between breast cancer risk for BRCA1 mutation carriers and risk of ER-negative breast cancer in the general population.

Roger L Milne
Karoline B Kuchenbaecker
Jacques Simard
Research23 Oct 2017
Nature Genetics

Volume: 49, P: 1767-1778
Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Paul Pharoah and colleagues report the results of a large genome-wide association study of ovarian cancer. They identify new susceptibility loci for different epithelial ovarian cancer histotypes and use integrated analyses of genes and regulatory features at each locus to predict candidate susceptibility genes, including OBFC1.

Catherine M Phelan
Karoline B Kuchenbaecker
Paul D P Pharoah
Research27 Mar 2017
Nature Genetics

Volume: 49, P: 680-691
Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

Tumor cells can fuel their metabolism with lactate. Here the authors show that inhibition of mitochondrial pyruvate carrier (MPC) blocks extracellular lactate uptake by promoting intracellular pyruvate accumulation and inhibits oxidative metabolism, ultimately resulting in cytotoxicity and radiosensitization.

Cyril Corbet
Estelle Bastien
Olivier Feron
ResearchOpen Access23 Mar 2018
Nature Communications

Volume: 9, P: 1-11
Association analysis identifies 65 new breast cancer risk loci

Association analysis identifies 65 new breast cancer risk loci, predicts target genes for known risk loci and demonstrates a strong overlap with somatic driver genes in breast tumours.

Kyriaki Michailidou
Sara Lindström
Douglas F. Easton
Research23 Oct 2017
Nature

Volume: 551, P: 92-94
Gilteritinib activity in refractory or relapsed FLT3-mutated acute myeloid leukemia patients previously treated by intensive chemotherapy and midostaurin: a study from the French AML Intergroup ALFA/FILO

Pierre-Yves Dumas
Emmanuel Raffoux
Christian Récher
Research14 Nov 2022
Leukemia

Volume: 37, P: 91-101
The sunflower genome provides insights into oil metabolism, flowering and Asterid evolution

A high-quality reference for the sunflower genome (Helianthus annuus L.) and analysis of gene networks involved in flowering time and oil metabolism provide a basis for nutritional exploitation and analyses of adaptation to climate change.

Hélène Badouin
Jérôme Gouzy
Nicolas B. Langlade
ResearchOpen Access22 May 2017
Nature

Volume: 546, P: 148-152
Consequences of in utero exposure to Zika virus in offspring of AG129 mice

Justin G. Julander
Venkatraman Siddharthan
John D. Morrey
ResearchOpen Access20 Jun 2018
Scientific Reports

Volume: 8, P: 1-11
High CD44 expression and enhanced E-selectin binding identified as biomarkers of chemoresistant leukemic cells in human T-ALL

Julien Calvo
Irina Naguibneva
Françoise Pflumio
ResearchOpen Access24 Nov 2024
Leukemia

Volume: 39, P: 323-336
Ibetazol, a novel inhibitor of importin β1-mediated nuclear import

Ibetazol, a novel compound efficiently and specifically inhibiting all importin β1-mediated nuclear import, will be a valuable tool for fundamental research into importin β1-mediated nuclear import mechanisms and a therapeutic lead in human diseases.

Thomas Vercruysse
Els Vanstreels
Dirk Daelemans
ResearchOpen Access23 Nov 2024
Communications Biology

Volume: 7, P: 1-14
Lomustine is beneficial to older AML with ELN2017 adverse risk profile and intermediate karyotype: a FILO study

Laetitia Largeaud
Pascale Cornillet-Lefebvre
A. Fayault
Research18 Sept 2020
Leukemia

Volume: 35, P: 1291-1300
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)

Hatef Darabi
Jonathan Beesley
Alison M. Dunning
ResearchOpen Access07 Sept 2016
Scientific Reports

Volume: 6, P: 1-14
Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

Juliette Coignard
Michael Lush
Antonis C. Antoniou
Amendments and CorrectionsOpen Access14 May 2021
Nature Communications

Volume: 12, P: 1-2
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli
Massimo Bogliolo
Paolo Peterlongo
ResearchOpen Access01 Nov 2019
npj Breast Cancer

Volume: 5, P: 1-14
Early skin-to-skin contact and risk of late-onset-sepsis in very and extremely preterm infants

Isabelle Le Ray
Pierre Kuhn
Héloïse Torchin
Research14 Nov 2022
Pediatric Research

Volume: 93, P: 2091-2100
Perceived maternal information on premature infant’s pain during hospitalization: the French EPIPAGE-2 national cohort study

Véronique Pierrat
Laetitia Marchand-Martin
J. M. Roué
Research13 May 2019
Pediatric Research

Volume: 87, P: 153-162

Search

Seasonal variations of antioxidant imbalance in Cuban healthy men

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication

A coronavirus assembly inhibitor that targets the viral membrane protein

The nature of soil blue carbon varies across mangrove geomorphic settings

Author Correction: Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

PIM2 inhibition promotes MCL1 dependency in plasma cells involving integrated stress response-driven NOXA expression

Publisher Correction: A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction

Axonal RNA localization is essential for long-term memory

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast–ovarian cancer susceptibility locus

Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

A pan-serotype dengue virus inhibitor targeting the NS3–NS4B interaction

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer

Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects

Association analysis identifies 65 new breast cancer risk loci

Gilteritinib activity in refractory or relapsed FLT3-mutated acute myeloid leukemia patients previously treated by intensive chemotherapy and midostaurin: a study from the French AML Intergroup ALFA/FILO

The sunflower genome provides insights into oil metabolism, flowering and Asterid evolution

Consequences of in utero exposure to Zika virus in offspring of AG129 mice

High CD44 expression and enhanced E-selectin binding identified as biomarkers of chemoresistant leukemic cells in human T-ALL

Ibetazol, a novel inhibitor of importin β1-mediated nuclear import

Lomustine is beneficial to older AML with ELN2017 adverse risk profile and intermediate karyotype: a FILO study

Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs)

Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Early skin-to-skin contact and risk of late-onset-sepsis in very and extremely preterm infants

Perceived maternal information on premature infant’s pain during hospitalization: the French EPIPAGE-2 national cohort study

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