Current efforts to enhance NMR signals using the signal amplification by reversible exchange (SABRE) focus on optimizing polarization transfer from parahydrogen-derived hydride ligands to the substrate, but this requires quantitative information on ligand exchange rates, which common NMR techniques struggle to provide. Here, the authors introduce an experimental spin order transfer sequence with readout occurring at hyperpolarization-enhanced 15N nuclei that are directly interacting with the SABRE catalyst, enabling robust evaluation of ligand chemical exchange.
- Charbel D. Assaf
- Xin Gui
- Andrey N. Pravdivtsev
