Hyperpolarized 13C MRI visualizes real-time metabolic processes in vivo, however, external polarizers are commonly required to produce hyperpolarized metabolites. Here, using a parahydrogen-based approach, the authors achieved up to 30% 13C polarization in situ in an MRI system for precursor molecules [1-13C]acetate and [1-13C]pyruvate ethyl esters in their perdeuterated forms, potentially facilitating future metabolic imaging applications.
- Obaid Mohiuddin
- Henri de Maissin
- Andreas B. Schmidt
