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Improved overall survival in an anti-PD-L1 treated cohort of newly diagnosed glioblastoma patients is associated with distinct immune, mutation, and gut microbiome features: a single arm prospective phase I/II trial

Checkpoint inhibitor (CPI) therapy is modestly effective in Glioblastoma patients, with some patients not benefitting at all. Authors here present the outcomes of single arm prospective clinical trial employing combination CPI therapy in newly diagnosed GBM and identify the pre-treatment genetic, microbiome and immunological factors that might contribute to sensitivity.

Shiao-Pei Weathers
Xiqi Li
John F. de Groot
ResearchOpen Access27 Apr 2025
Nature Communications

Volume: 16, P: 1-13
A randomized, non-comparative phase 2 study of neoadjuvant immune-checkpoint blockade in retroperitoneal dedifferentiated liposarcoma and extremity/truncal undifferentiated pleomorphic sarcoma

Roland et al. report the results of a randomized, non-comparative phase 2 trial of neoadjuvant nivolumab or a combination of nivolumab and ipilimumab in patients with resectable retroperitoneal dedifferentiated liposarcoma and extremity/truncal undifferentiated pleomorphic sarcoma.

Christina L. Roland
Elise F. Nassif Haddad
Neeta Somaiah
Research13 Feb 2024
Nature Cancer

Volume: 5, P: 625-641
Diet-driven microbial ecology underpins associations between cancer immunotherapy outcomes and the gut microbiome

A prospective analysis of gut microbiome signatures in patients treated with neoadjuvant immunocheckpoint blockade for high risk resectable metastatic melanoma identifies new links between microbiota signatures, dietary intake and systemic inflammation in shaping the response and toxicity to immunotherapy.

Rebecca C. Simpson
Erin R. Shanahan
Georgina V. Long
Research22 Sept 2022
Nature Medicine

Volume: 28, P: 2344-2352
Vaccine-linked chemotherapy induces IL-17 production and reduces cardiac pathology during acute Trypanosoma cruzi infection

Julio V. Cruz-Chan
Liliana E. Villanueva-Lizama
Kathryn M. Jones
ResearchOpen Access05 Feb 2021
Scientific Reports

Volume: 11, P: 1-13

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Improved overall survival in an anti-PD-L1 treated cohort of newly diagnosed glioblastoma patients is associated with distinct immune, mutation, and gut microbiome features: a single arm prospective phase I/II trial

A randomized, non-comparative phase 2 study of neoadjuvant immune-checkpoint blockade in retroperitoneal dedifferentiated liposarcoma and extremity/truncal undifferentiated pleomorphic sarcoma

Diet-driven microbial ecology underpins associations between cancer immunotherapy outcomes and the gut microbiome

Vaccine-linked chemotherapy induces IL-17 production and reduces cardiac pathology during acute Trypanosoma cruzi infection

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