Search

InterpolAI leverages optimal flow-based artificial intelligence to produce synthetic images between pairs of images for diverse three-dimensional image types. InterpolAI is more robust and accurate than existing methods, improving data quality for downstream analysis.

Translocation renal cell carcinoma (tRCC) is driven by MiT family gene fusions. Here, the authors demonstrate that RNA-binding features of TFE3 fusions facilitate condensate formation, promoting transcriptional hub assembly and oncogenic gene activation.

The placenta plays vital roles in supporting fetal development. Here, Richards et al. develop a high-throughput bioprinted trophoblast organoid model to recapitulate the microenvironment of the early placenta, enabling investigation of placenta development and evaluation of therapeutics for placenta dysfunction disorders.

Anode-free batteries are cost effective but limited by unstable anode morphology and interface reactions. Here the authors discuss design parameters and construct an anode-free sodium solid-state battery using compressed aluminium particles as the anode current collector to improve cycling performance.

Imaging macrophage trafficking in solid tumors has implications for cancer diagnosis and prognosis. by labeling macrophages with lipid-shelled microbubbles in combination with ultrasound, the authors here achieve nondestructive in vivo intravenously administrated macrophage imaging at single cell level with 100 µm resolution till 8 h in solid tumors in rodents.

High-power mechanical energy harvesting could be an alternative to batteries, but efficient energy conversion technology has been missing. Here, a novel mechanical-to-electrical energy conversion method is described that is based on reverse electrowetting and is uniquely suited for high-power energy harvesting.

Wang, Tang and colleagues develop the low-signal signed iterative random forest pipeline to investigate epistasis in the genetic control of cardiac hypertrophy, identifying epistatic variants near CCDC141, IGF1R, TTN and TNKS loci, and show that hypertrophy in induced pluripotent stem cell-derived cardiomyocytes is nonadditively influenced by interactions among CCDC141, TTN and IGF1R.

Above band-gap photovoltage could be achieved in materials with a net polarization. Here, Cooket al. compute the contribution to the shift current from the band edge and identify two classes of shift current photovoltaics materials, GeS and ferroelectric polymer films.

We correlate lab test and field test results to better predict the performance of perovskite photovoltaics as a step towards real-world implementation.

The neuronal composition of the intestinal submucosal plexus is incompletely understood. Here Li et al. define their neuron classes, connectome and stepwise acquisition of identities.

Through analysis of developing chick embryos and in vitro differentiation of embryonic stem cells, a study develops a method to generate a model of the human trunk with a notochord.

Growth and differentiation of pulmonary epithelial cells is precisely controlled to form the alveoli that create the gas exchange region of the lung. Here, the authors demonstrate that epigenetic modulation of the genome by PRDM3/16 mediates NKX2-1 activity to control alveolar cell fate and differentiation during embryonic and perinatal lung development.

Quantitative multimodal 3D reconstruction of human pancreatic tissue at single-cell resolution reveals a high burden of multifocal, genetically heterogeneous pancreatic intraepithelial neoplasias in the normal adult pancreas.

Raman and fluorescence spectra, consistent with several species of aromatic organic molecules, are reported in the Crater Floor sequences of Jezero crater, Mars, suggesting multiple mechanisms of organic synthesis, transport, or preservation.

The authors report that MeCP2, a methyl DNA–binding transcriptional regulator, modulates the response to amphetamine in the nucleus accumbens. Using both acute viral manipulation of MeCP2 in mice and hypomorphic Mecp2 mutant mice, they find that MeCp2 both affects mesolimbocortical circuit development and regulates the responses to psychostimulants.

CODA: a method for 3D reconstruction of large serially sectioned tissues.

A climatic record from desert speleothems shows that the central Arabian interior experienced recurrent humid intervals over the past 8 million years, which likely facilitated mammalian dispersals between Africa and Eurasia.

Large language models can be manipulated to generate misinformation by poisoning of a very small percentage of the data on which they are trained, but a harm mitigation strategy using biomedical knowledge graphs can offer a method for addressing this vulnerability.

This study shows that typhoid toxin disrupts the blood–brain barrier leading to vascular leakage, inflammation and neurological symptoms, causing encephalopathy in typhoid fever. Corticosteroids help mitigate these effects.

FlyWire presents a neuronal wiring diagram of the whole fly brain with annotations for cell types, classes, nerves, hemilineages and predicted neurotransmitters, with data products and an open ecosystem to facilitate exploration and browsing.

The APOBEC3 family cytidine deaminases with antiviral activity are proteins that catalyze the deamination of newly reverse-transcribed viral DNA. Here the authors present the crystal structure of full-length pig-tailed macaque APOBEC3H with bound RNA, which reveals how the APOBEC3H dimer binds around a short RNA duplex.

ZO-1, a cell junction protein, is essential for angiogenesis. Here the authors identify in endothelial cells unexpected associations of ZO-1 with stress granule proteins, such as YB-1, that are crucial for cytoprotection, implicating the ZO-1-YB-1 interaction in angiogenesis.

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

The use of NISQ devices for useful quantum simulations of materials and chemistry is still mainly limited by the necessary circuit depth. Here, the authors propose to combine classically-generated effective Hamiltonians, hybrid fermion-to-qubit mapping and circuit optimisations to bring this requirement closer to experimental feasibility.

Lamin mutations responsible for muscular dystrophy are shown to reduce nuclear envelope stability, resulting in mechanically induced nuclear envelope rupture, DNA damage and activation of DNA damage response pathways that lead to muscle cell death. Preventing nuclear envelope damage by reducing cytoskeletal forces on the nucleus improves muscle fibre health and function.

The cryo-EM structure of human polycystin-2 (PC2) in a closed conformation reveals a domain located above the pore filter, forming an upper vestibule and making contacts with the pore and voltage-sensor-like domains.

l-Lactate is increasingly recognized as a key metabolite and signalling molecule in mammals, but the methods to investigate it in vivo have been limited. Here, authors report a pair of improved biosensors—one green and one red—for visualizing l-lactate both inside and outside of cells.

Using single-molecule super-resolution microscopy, researchers revealed that Tau controls the recycling pool of synaptic vesicles in hippocampal neurons by forming nanoscale biomolecular condensates that are dynamically regulated by neuronal activity.

All-solid-state batteries with silicon anodes have high capacities but low initial coulombic efficiencies (ICEs) because of first cycle irreversible capacity loss. Here, the authors report a prelithiation strategy to improve ICEs and reversibility.

Dopaminergic circuits in the nucleus accumbens regulate reward, including social play behavior in adolescent rodents. Here, the authors show that in male but not female rats, dopamine receptors are tagged by complement for microglial phagocytosis, thus mediating changes in social behavior.

Here, the authors perform statistical measurements on hundreds of plasmonic nano-cavities embedding WSe₂ monolayers, and show the activation of anti-Stokes photoluminescence in WSe₂ through resonant excitation of a dark exciton at room temperature.

Two below-threshold surface code memories on superconducting processors markedly reduce logical error rates, achieving high efficiency and real-time decoding, indicating potential for practical large-scale fault-tolerant quantum algorithms.

Izar and colleagues demonstrate that loss of Pip4k2c in melanoma cells promotes liver metastatic tropism driven by PI3K-AKT pathway activation in the insulin-rich liver milieu, which can be abrogated by inhibition of SGLT2 or a ketogenic diet.

Hibernating ground squirrels have negligible hunger despite a months-long period of food deprivation and cold exposure. Here, authors show that prolonged anorexia is enabled by inhibition of the hypothalamic feeding center due to central hypothyroidism.

Cells survive starvation by activating protective pathways. Here, the authors describe that kinase EFK-1/eEF2K defends against oxidative damage in long term starvation in C. elegans independently from its kinase activity and translation regulation.

A mid-Holocene expansion of coastal sea ice led to phytoplankton blooms’ becoming less frequent off East Antarctica, according to a suite of annually resolved physical and geochemical analyses performed on a marine sediment core.

A head-to-head double-ring complex of the human multifunctional DNA repair protein RAD52 mediates protection of stalled replication forks during replication stress, protecting them from reversal by SMARCAL1 motor.

Rational design has endowed self-assembling peptides with structural similarities to natural materials, but recreating the dynamic functional properties inherent to natural systems remains challenging. Here the authors report the discovery of a short peptide based on the tryptophan zipper motif, that shows multiscale hierarchical ordering into hydrogels that display emergent dynamic properties.

The structures of the biotin-dependent carboxylases have revealed details of their function. Here, the authors describe the first structure of Pseudomonasgeranyl-CoA carboxylase, and compare it with the previously characterised homologous 3-methylcrotonyl-CoA carboxylase.

Mapping of the global potential of atmospheric water harvesting using solar energy shows that it could provide safely managed drinking water for a billion people worldwide based on climate suitability.

The cytoplasmic droplet is an elusive structure of mammalian sperm. Here, the authors uncover a key gene that defines a vesicular pathway essential for cytoplasmic droplet formation and male fertility.

Old or diseased human glial cells in the chimeric mouse brain are eliminated by transplanted young cells.

Clathrin light chain (CLC) subunits are dispensable for clathrin-mediated endocytosis of a number of cargoes. Majeed et al. report that CLCs are however required for gyrating-clathrin-dependent recycling of inactive β1-integrins, the absence of which impairs cell migration.

TMEM16K is a member of the TMEM16 family of integral membrane proteins that are either lipid scramblases or chloride channels. Here the authors combine cell biology, electrophysiology measurements, X-ray crystallography, cryo-EM and MD simulations to structurally characterize TMEM16K and show that it is an ER-resident lipid scramblase.

Aminoadamantane compounds, delivered to cells via binding to viroporin channels, induce S-nitrosylation of the ACE2 protein, inhibiting binding to SARS-CoV-2 spike protein and viral infection.

The prevalence of centrosome amplification (CA) and the genomic landscape of chromosomal instability in high-grade serous ovarian carcinoma (HGSOC) remain to be explored. Here the authors suggest CA as a potential driver of tumour evolution and a biomarker for treatment response in HGSOC.

The DNA-binding domains of transcription factors have been well characterized, but whether their intrinsically disordered regions control cell fate is unclear. Here, the authors show the functional and mechanistic importance of an intrinsically disordered region of TCF-1 in T cell development.