Nature Search

The filamentous ultrastructure of the PopZ condensate is required for its cellular function

Scholl et al. show that PopZ forms filamentous condensates driven by its helical domain and inhibited by its disordered region. Phase-dependent conformations modulate client interactions and disruption of filamentation or condensation impairs cellular function and growth.

Daniel Scholl
Tumara Boyd
Keren Lasker
ResearchOpen Access02 Feb 2026
Nature Structural & Molecular Biology

P: 1-13
Ultrafast cooling reveals microsecond-scale biomolecular dynamics

Temperature jump technique is widely used to probe the fast dynamics of protein and DNA folding, but constrained to modest temperature control. Here, the authors use a microfluidic device combined with an infrared laser to heat or cool DNA hairpins up to 70 °C on a microsecond time scale.

Mark E. Polinkovsky
Yann Gambin
Ashok A. Deniz
Research17 Dec 2014
Nature Communications

Volume: 5, P: 1-7
Reentrant DNA shells tune polyphosphate condensate size

Polyphosphate affects many cellular processes and is often found near cellular DNA. Here, the authors show that DNA forms shells around polyP-Mg²⁺ condensates in vitro, controlling condensate size and DNA morphology in a manner dependent on DNA properties.

Ravi Chawla
Jenna K. A. Tom
Lisa R. Racki
ResearchOpen Access26 Oct 2024
Nature Communications

Volume: 15, P: 1-15
A cryptic pocket in CB1 drives peripheral and functional selectivity

A peripherally restricted CB1 agonist (VIP36) targeting a cryptic receptor pocket was developed, showing high efficacy in mouse pain models with minimal side effects and tolerance, potentially revolutionizing chronic pain treatment and GPCR drug design.

Vipin Ashok Rangari
Evan S. O’Brien
Susruta Majumdar
Research05 Mar 2025
Nature

Volume: 640, P: 265-273
Enzymes can adapt to cold by wiggling regions far from their active site

Mutations introduced far from the active site of an enzyme can cause local unfolding that increases enzyme activity. This finding suggests how organisms that live in the cold can speed up biochemical reactions.

Ashok A. Deniz
News & Views06 Jun 2018
Nature

Volume: 558, P: 195-196
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Research28 Feb 2019
Nature Genetics

Volume: 51, P: 414-430
Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing

A laminar flow mixing microfluidic device enables single-molecule fluorescence resonance energy transfer (FRET) kinetic measurements with a time resolution of 0.2 ms, enabling the study of early binding-coupled folding and unfolding events of an intrinsically disordered protein, α-synuclein. Also in this issue, Kim et al. describe another microfluidic mixing device for single-molecule experiments.

Yann Gambin
Virginia VanDelinder
Ashok A Deniz
Research06 Feb 2011
Nature Methods

Volume: 8, P: 239-241
Spatial and functional arrangement of Ebola virus polymerase inside phase-separated viral factories

Here, the authors characterized the phase separation properties and internal structures of intracellular viral factories induced by Ebola virus and correlated these properties to important steps of viral biogenesis.

Jingru Fang
Guillaume Castillon
Erica Ollmann Saphire
ResearchOpen Access13 Jul 2023
Nature Communications

Volume: 14, P: 1-16
The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems

“Intracellular phase separation is emerging as a universal principle for organizing biochemical reactions in time and space. Here the authors show that PopZ condensate dynamics support cell division and using PopZ modular architecture, the tunable PopTag platform was developed to enable designer condensates.”

Keren Lasker
Steven Boeynaems
Lucy Shapiro
ResearchOpen Access26 Sept 2022
Nature Communications

Volume: 13, P: 1-15
Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation

The nucleolus is a membrane-less organelle formed through liquid–liquid phase separation (LLPS). Here the authors use biophysical methods and show that the nucleolar protein nucleophosmin (NPM1) also undergoes LLPS through homotypic, inter-NPM1 interactions and discuss implications for the ribosome biogenesis process.

Diana M. Mitrea
Jaclyn A. Cika
Richard W. Kriwacki
ResearchOpen Access26 Feb 2018
Nature Communications

Volume: 9, P: 1-13
Modulation of allostery by protein intrinsic disorder

Single-molecule FRET is used to examine how an intrinsically disordered protein, the adenovirus E1A oncoprotein, interacts with two different protein partners (the pocket domain of pRb and the TAZ2 domain of CBP/p300); the biophysical behaviour of E1A depends on whether the N-terminal region and/or the CR2 region of E1A is free to interact with potential protein partners or whether they are ‘masked’ (that is, via their absence or a pre-existing interaction with another protein partner).

Allan Chris M. Ferreon
Josephine C. Ferreon
Ashok A. Deniz
Research19 Jun 2013
Nature

Volume: 498, P: 390-394
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2, ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes to the development of Alzheimer's disease.

Rebecca Sims
Sven J van der Lee
Gerard D Schellenberg
Research17 Jul 2017
Nature Genetics

Volume: 49, P: 1373-1384
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Amendments and Corrections15 Aug 2019
Nature Genetics

Volume: 51, P: 1423-1424
Divalent cations can control a switch-like behavior in heterotypic and homotypic RNA coacervates

Paulo L. Onuchic
Anthony N. Milin
Priya R. Banerjee
ResearchOpen Access21 Aug 2019
Scientific Reports

Volume: 9, P: 1-10
A novel Alzheimer disease locus located near the gene encoding tau protein

G Jun
C A Ibrahim-Verbaas
L A Farrer
Research17 Mar 2015
Molecular Psychiatry

Volume: 21, P: 108-117

Search

The filamentous ultrastructure of the PopZ condensate is required for its cellular function

Ultrafast cooling reveals microsecond-scale biomolecular dynamics

Reentrant DNA shells tune polyphosphate condensate size

A cryptic pocket in CB1 drives peripheral and functional selectivity

Enzymes can adapt to cold by wiggling regions far from their active site

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Visualizing a one-way protein encounter complex by ultrafast single-molecule mixing

Spatial and functional arrangement of Ebola virus polymerase inside phase-separated viral factories

The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems

Self-interaction of NPM1 modulates multiple mechanisms of liquid–liquid phase separation

Modulation of allostery by protein intrinsic disorder

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Divalent cations can control a switch-like behavior in heterotypic and homotypic RNA coacervates

A novel Alzheimer disease locus located near the gene encoding tau protein

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