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Showing 1–3 of 3 results
Advanced filters: Author: Aslihan Karabacak Clear advanced filters

  • Patients with MMR-proficient, microsatellite stable (MSS) colorectal cancer (CRC) are highly resistant to immune-checkpoint inhibitors. Here the authors report that tumor intrinsic expression of the autophagy gene ATG16L1 is associated with resistance to anti-tumor immunity in preclinical CRC models and that elevated ATG16L1 expression predicts poor immunotherapy response in Kras-mutant CRC patients.

    • Lucia Taraborrelli
    • Yasin Şenbabaoğlu
    • Aditya Murthy
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Single-cell and genetic tools are used to characterize the diversity of fibroblasts across healthy and perturbed tissues in mice and humans.

    • Matthew B. Buechler
    • Rachana N. Pradhan
    • Shannon. J. Turley
    Research
    Nature
    Volume: 593, P: 575-579

  • Divergent transcription from promoters and enhancers occurs in many species, but it is unclear if it is a general feature of all eukaryotic cis regulatory elements. Here the authors define cis regulatory elements in worms, flies, and human; and identify several differences in regulatory architecture among metazoans.

    • Mahmoud M. Ibrahim
    • Aslihan Karabacak
    • Uwe Ohler
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15