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Showing 1–4 of 4 results
Advanced filters: Author: Audra E. Devoto Clear advanced filters

  • RNA-guided CRISPR-associated transposases (CAST) are natural systems with broad potential in biotechnology. Here, the authors report compact type V-K CAST discovered from genome-resolved metagenomics and demonstrate targeted integration of a large transgene to a safe-harbor site in the human genome.

    • Jason Liu
    • Daniela S. Aliaga Goltsman
    • Brian C. Thomas
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Programmable, RNA-guided nucleases are diverse enzymes that have been repurposed for biotechnological applications. Here, the authors mine an extensive genome-resolved metagenomics database and identified uncharacterized families of RNA-guided, compact nucleases.

    • Daniela S. Aliaga Goltsman
    • Lisa M. Alexander
    • Christopher T. Brown
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Genomic analyses of major clades of huge phages sampled from across Earth’s ecosystems show that they have diverse genetic inventories, including a variety of CRISPR–Cas systems and translation-relevant genes.

    • Basem Al-Shayeb
    • Rohan Sachdeva
    • Jillian F. Banfield
    ResearchOpen Access
    Nature
    Volume: 578, P: 425-431

  • Here the authors discover megaphages, or Lak phages, with genomes >540 kilobases in length in the gut microbiomes of a range of hosts, identify Prevotella as the bacterial host and suggest that these phages are common members of the mammalian gut microbiome.

    • Audra E. Devoto
    • Joanne M. Santini
    • Jillian F. Banfield
    ResearchOpen Access
    Nature Microbiology
    Volume: 4, P: 693-700