Search

Assessing brain aging heterogeneity in a cohort of 49,482 individuals from 11 studies, a generative model identifies five dominant patterns of brain atrophy, with specific associations with biomedical, lifestyle and genetic factors.

Sedimentary osmium isotopes from the Gulf of Mexico indicate that after the Cretaceous-Paleogene impact, nutrients were supplied by hydrothermal activity for 700 kyr and may have contributed to the post-extinction recovery of the marine ecosystem

Drip-like features imaged in a seismic tomography model are consistent with extensive ongoing thinning of cratonic lithosphere beneath North America.

Achieving mitigation from forests aligned with #NDCs requires $20–72 billion annually by 2030. Global coordination could double mitigation with the same level of finance, revealing major efficiency gains and informing next generation climate targets.

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) is a rare but life-threatening severe cutaneous drug reaction mediated by CD8⁺ T cells. Here the authors characterise the immune response in skin samples at the site of tissue damage from patients affected with SJS/TEN and compare this to healthy skin or blister fluid and find populations of CD8⁺ T cell clonotypes expressing cytotoxic mediator molecules.

A mitochondrial complex I inhibitor exhibited dose-limiting toxicities, including neurotoxicity, in patients with acute myeloid leukemia and solid tumors, warranting further studies to evaluate the mechanism linking oxidative phosphorylation inhibition and neurotoxicity.

Engineered living materials harness the computational power of biology to control interesting material properties. Here the authors leverage complex transcriptional regulation of bacterial extracellular electron transfer to control hydrogel cross-linking with Boolean logic.

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

The glia limitans is formed by astrocytes at CNS borders and acts as a barrier to molecules and immune cells. Here, using an Aqp4-mRuby3 knock-in mouse, the authors visualize this barrier and its role in CNS immune surveillance and neuroinflammation.

Ossenkoppele, Salvado et al. show that plasma p-tau217 and tau-PET predict cognitive decline equally well among cognitively unimpaired individuals. Their combined use further boosts prognostic accuracy. A sequential approach can enhance precision and efficiency of preclinical Alzheimer trials.

Using a freestanding planar lipid membrane system, the authors show that liquid-like protein condensates on one side of a lipid membrane colocalize with those on the opposite side, suggesting a mechanism of information transfer across biological membranes.

Certain materials without inversion symmetry may allow for a nonlinear anomalous Hall effect with conserved time reversal symmetry. Here, the authors report an extremely large c-axis nonlinear anomalous Hall effect in the non-centrosymmetric T_d phase of MoTe₂ and WTe₂ without intrinsic magnetic order that is dominated by extrinsic scattering.

The brain predicts future sensory input. The authors hypothesize that the visual system achieves this by straightening the temporal trajectories of natural videos, and they provide evidence using human perceptual experiments and computational modeling.

This study reveals that jellyfish swimming can be guided and predicted using electrical stimulation and machine learning, illustrating how embodied intelligence shapes both spontaneous and stimulus-evoked behaviors.

Many behaviours depend on predictions about the environment. Here the authors find neural populations in primary visual cortex to straighten the temporal trajectories of natural video clips, facilitating the extrapolation of past observations.

Siles Alvarado and Schuler et al. examine the long-term dynamics of SARS-CoV-2 antibodies in individuals with varying COVID-19 severities over 12 months. While anti-N antibodies decline, anti-RBD antibodies persist, offering insights into the evolving immunity post-COVID.

This study determined the structure of the spike protein of the SARS-CoV-2 omicron variant, revealing a predominantly open conformation of the molecule that may help omicron infect cells more efficiently than do previous variants.

Simulations of Milky Way-like star clusters show that most (>57%) stars form in multiples. Approximately 75% of binaries are gravitationally bound from the birth of the secondary, and ~40% of (eventual) single stars originated in a multiple system.

Yelland et al. use yeast genetics and cryo-EM to show how 2′-O-methylation on a single rRNA base gates the assembly of the ribosome via regulating interaction with the essential GTPase Nog2.

Our understanding of microbial diversity and physiology in marine sediments is limited. Here, Gong et al. analyze thousands of metagenome-assembled genomes (MAGs) from coastal and deep-sea sediments, and identify MAGs belonging to new bacterial phyla that seem able to mediate key steps in sedimentary biogeochemistry.

Dendritic distortion is problematic for neurons using temporal coding strategies, such as medial superior olivary neurons, which encode microsecond differences in binaural auditory input. Mathews et al. find that both the specific activation properties and spatial distribution of K_v1 channels compensate for passive cable filtering, helping to preserve binaural synaptic timing.

Deshpande et al show that MRN nuclease-dependent processing of DNA ends in human cells occurs at sites bound by DNA-PK. Chromatin immunoprecipitation analysis of DNA-PK, MRN, and CtIP supports a sequential model of pathway choice.

The lateral intraparietal area (LIP) in monkeys plays an important role in decision-making. Here the authors use a statistical approach to decode the activity of LIP spikes and find multiplexed and temporally heterogeneous signals. This provides a framework for studying complex coding in higher brain areas.

The enzymatic properties of RNA-guided nucleases are revealed through massively parallel analysis.

The authors establish a connection between functional subtypes and genetic subtypes of dopamine neurons in mice and demonstrate that molecular expression patterns can serve as a common framework to dissect dopaminergic functions.

Here, the authors use cryo electron tomography to investigate the in-situ assembly mechanisms of clustered protocadherin γB4, uncovering the functional contributions of full-length γB4 and role played by specific domains.

Polygenic risk scores can help identify individuals at higher risk of type 2 diabetes. Here, the authors characterise a multi-ancestry score across nearly 900,000 people, showing that its predictive value depends on demographic and clinical context and extends to related traits and complications.

In this work, the authors demonstrate a 2D memristor with high switching speeds of 120 ps and study its dynamic response with 3 ns short voltage pulses using statistical analysis, simulation, and modeling.

Tau pathology drives neuronal dysfunction in 4- repeat tauopathies. Here, the authors combine tau-PET, resting-state fMRI and histopathology data, to show that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.

Together with an accompanying paper presenting a transcriptomic atlas of the mouse lemur, interrogation of the atlas provides a rich body of data to support the use of the organism as a model for primate biology and health.

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Our current understanding of neurofibromatosis type 1 (NF1) is based on patients ascertained through phenotype-first approaches, which estimate a low prevalence at 1 in 3,000. Here, the authors leverage a genotype-first approach in multiple large patient cohorts to demonstrate an unexpectedly high prevalence (1 in 1,286) of NF1 pathogenic variants with distinct disease associations.

Lanthanides are in high global demand and a sustainable extraction practice is needed to keep pace. Here, Huang and colleagues reengineer fluorescent protein surface charges to bind and detect lanthanides.

Fisher et al. combine sediment geochemistry and climate modelling to reveal long-term synchrony between erosion rates and orbitally-driven climate oscillations in the tectonically-active southern Central Andes.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Tang et al. show that continuous language can be decoded from functional MRI recordings to recover the meaning of perceived and imagined speech stimuli and silent videos and that this language decoding requires subject cooperation.

This study characterizes the world’s largest seagrass ecosystem in The Bahamas by integrating spatial estimates with remote sensing and performing extensive ground-truthing of benthic habitat with 2,542 diver surveys, as well as data obtained from instrument-equipped tiger sharks, which have strong fidelity to seagrass ecosystems.

APOBEC3B interacts with R-loops and helps mediate their resolution in a deamination-dependent way. This association also renders R-loops susceptible to enhanced APOBEC3B-dependent mutagenesis.

Analyses of the TRACERx study unveil the relationship between tissue morphology, the underlying evolutionary genomic landscape, and clinical and anatomical relapse risk of lung adenocarcinomas.

Interactions between electroactive bacteria and metal oxides are used for bioremediation. Here, the authors report on the application of Fe(III)-containing metal organic frameworks as substrates for bacterial growth which allow for remediation of lethal levels of chromium with high efficacy over several cycles.

Climate change is a major threat to biodiversity. This study predicts that climate change will reshape Neotropical frog diversity, causing losses in phylogenetic diversity and phylogenetic endemism, with many species facing severe range contractions by 2050.