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Showing 1–50 of 73 results

Advanced filters: Author: B Edelmann Clear advanced filters

DNA2 and MSH2 cooperatively repair stabilized G4 and allow efficient telomere replication

Resolution of G4s has been suggested to be required for efficient DNA replication. Here, the authors show that the nuclease DNA2 and the DNA repair complex MutSα (MSH2-MSH6) are required to remove G4 stabilized by environmental compounds to allow efficient telomere replication.

Anthony Fernandez
Tingting Zhou
Binghui Shen
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-15
Polygenic risk score for type 2 diabetes shows context-dependent effects across populations

Polygenic risk scores can help identify individuals at higher risk of type 2 diabetes. Here, the authors characterise a multi-ancestry score across nearly 900,000 people, showing that its predictive value depends on demographic and clinical context and extends to related traits and complications.

Boya Guo
Yanwei Cai
Burcu F. Darst
ResearchOpen Access01 Oct 2025
Nature Communications

Volume: 16, P: 1-16
Maturational Changes in Renal Blood Flow in Piglets

Alan B Gruskin
Chester M Edelmann Jr.
Stanley Yuan
Research01 Jan 1970
Pediatric Research

Volume: 4, P: 7-13
Combined endurance and resistance exercise training in heart failure with preserved ejection fraction: a randomized controlled trial

In a multicenter, randomized trial, patients with heart failure with preserved ejection fraction who underwent a regimen of combined endurance and resistance exercise training over the course of 1 year did not show a statistically significant improvement in the modified Packer score—the primary efficacy endpoint—as compared to patients who received usual care, but they did show improvements in secondary endpoints for maximal oxygen consumption and NYHA heart failure class.

Frank Edelmann
Rolf Wachter
Martin Halle
ResearchOpen Access02 Jan 2025
Nature Medicine

Volume: 31, P: 306-314
Renal Acid-Base Titration Studies in Infants with and without Metabolic Acidosis in the Postneonatal Period

N W Svenningsen
Research01 Jun 1974
Pediatric Research

Volume: 8, P: 659-672
Carbonic Anhydrase in the Human Fetal Kidney

Gudmar Lönnerholm
Per J Wistrand
Research01 May 1983
Pediatric Research

Volume: 17, P: 390-397
Modeling the genomic architecture of adiposity and anthropometrics across the lifespan

Body size and composition are complex traits that are challenging to characterize due to environmental and genetic influences. Here, Arehart et al. disentangle shared and distinct genetic signals underlying body size and composition.

Christopher H. Arehart
Meng Lin
Luke M. Evans
ResearchOpen Access13 Aug 2025
Nature Communications

Volume: 16, P: 1-16
Renal Function Studies and Kidney Pyruvate Garboxylase in Subacute Necrotizing Encephalomyelopathy (Leigh's Syndrome)

Alan B Gruskin
Mulchand S Patel
Warren Grover
Research01 Oct 1973
Pediatric Research

Volume: 7, P: 832-841
The DNA sequence of human chromosome 22

I. Dunham
A. R. Hunt
K. P. O'Brien
Research02 Dec 1999
Nature

Volume: 402, P: 489-495
Intrarenal Blood Flow in Children with Normal Kidneys and Congenital Heart Disease: Changes Attributable to Angiography

Alan B Gruskin
Victor H Auerbach
Iain F S Black
Research01 May 1974
Pediatric Research

Volume: 8, P: 561-572
Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins

J M Bugni
L B Meira
L D Samson
Research24 Nov 2008
Oncogene

Volume: 28, P: 734-741
Effects of Positive Pressure Ventilation on Intrarenal Blood Flow in Infant Primates

Eddie S Moore
Maurina B Galvez
Richard E Behrman
Research01 Sept 1974
Pediatric Research

Volume: 8, P: 792-796
Mlh1 mediates tissue-specific regulation of mitotic recombination

Changshun Shao
Li Deng
Jay A Tischfield
Research11 Oct 2004
Oncogene

Volume: 23, P: 9017-9024
Telemedicine-supported lifestyle intervention for glycemic control in patients with CHD and T2DM: multicenter, randomized controlled trial

A randomized controlled trial showed that a home-based, telemedicine-supported lifestyle intervention, which consisted of exercise training, nutrition recommendations and health literacy training, reported improved glycemic control after 6 months in patients with coronary heart disease and type 2 diabetes compared to usual care.

Stephan Mueller
Sophia M. T. Dinges
Martin Halle
ResearchOpen Access07 Feb 2025
Nature Medicine

Volume: 31, P: 1203-1213
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

Chronic obstructive pulmonary disease is a progressive and incurable chronic condition that involves accumulation of inflammatory macrophages in the lung tissue. Authors here show in mouse models of lung disease that PRMT7, a protein arginine methyltransferase, is an important regulator of recruitment and the pro-inflammatory phenotype of macrophages.

Gizem Günes Günsel
Thomas M. Conlon
Ali Önder Yildirim
ResearchOpen Access14 Mar 2022
Nature Communications

Volume: 13, P: 1-21
PULMONARY May 17, 1973, 2:00 P.M. Continental Ballroom 6

Robert B Mellins
Research01 Apr 1973
Pediatric Research

Volume: 7, P: 59-168
H1 histones control the epigenetic landscape by local chromatin compaction

Experiments using a conditional triple-knockout mouse strain show that histone H1 regulates the activity of chromatin domains by controlling chromatin compaction, genome architecture and histone methylation.

Michael A. Willcockson
Sean E. Healton
Arthur I. Skoultchi
Research09 Dec 2020
Nature

Volume: 589, P: 293-298
The Development of Pediatric Nephrology

Russell W Chesney
Research01 Nov 2002
Pediatric Research

Volume: 52, P: 770-778
Plasma Renin Activity Related to Sodium Balance, Renal Function and Urinary Vasopressin in the Newborn Infant

Claude Godard
Jean-Marc Geering
Michel B Vallotton
Research01 Jun 1979
Pediatric Research

Volume: 13, P: 742-745
Rapidly Progressive Glomerulonephritis in Children: A Report of Thirteen Cases and a Review of the Literature

Robert J Cunningham III
Mason Gilfoil
Thomas Petrusick
Research01 Feb 1980
Pediatric Research

Volume: 14, P: 128-132
The Effects Of X-Irradiation on Adrenal Function in Man

C B Hatfield
S Shuster
Research01 Dec 1958
British Journal of Cancer

Volume: 12, P: 518-523
Compensatory Renal Growth in the Mouse. I. Allometric Approach to the Effect of Age

J M Hutson
A B Holt
D B Cheek
Research01 Oct 1981
Pediatric Research

Volume: 15, P: 1370-1374
Interleukin-10 determines viral clearance or persistence in vivo

David G Brooks
Matthew J Trifilo
Michael B A Oldstone
Research15 Oct 2006
Nature Medicine

Volume: 12, P: 1301-1309
A Review: Short Stature in Renal Disease

Gunnar B Stickler
Barry J Bergen
Research01 Dec 1973
Pediatric Research

Volume: 7, P: 978-982
Further Definition of Lipid-Lipoprotein Abnormalities in Children with Various Degrees of Chronic Renal Insufficiency

G Zacchello
A Pagnan
P Facchin
Research01 May 1987
Pediatric Research

Volume: 21, P: 462-465
Arginine methylation regulates the p53 response

The tumour suppressor p53 is subject to complex regulation and arginine methylation is now shown to provide an additional level of control. The protein arginine methyltransferase (PRMT) 5 is recruited by Strap to methylate p53 in response to DNA damage, governing the p53 response.

Martin Jansson
Stephen T. Durant
Nicholas B. La Thangue
Research16 Nov 2008
Nature Cell Biology

Volume: 10, P: 1431-1439
The effect of Na₂SO₄ on urinary acidification in the intact fetal lamb

Eddie S Moore
Clarence W Delannoy
Richard Behrman
Research01 Aug 1971
Pediatric Research

Volume: 5, P: 382
Proteome survey reveals modularity of the yeast cell machinery

Anne-Claude Gavin
Patrick Aloy
Giulio Superti-Furga
Research22 Jan 2006
Nature

Volume: 440, P: 631-636
Progress in Nuclear Science

E. B. PAUL
Books & Arts14 Jul 1956
Nature

Volume: 178, P: 57-58
Identification of rare de novo epigenetic variations in congenital disorders

A proportion of neurodevelopmental disorder and congenital anomaly cases remain without a genetic diagnosis. Here, the authors study aberrations of DNA methylation in such cases and find that epivariations might provide an explanation for some of these undiagnosed patients.

Mafalda Barbosa
Ricky S. Joshi
Andrew J. Sharp
ResearchOpen Access25 May 2018
Nature Communications

Volume: 9, P: 1-11
Effects of blood pressure lowering in patients with heart failure with preserved ejection fraction: a systematic review and meta-analysis

Hiroaki Kawano
Akira Fujiwara
Hisatomi Arima
Research05 Apr 2019
Hypertension Research

Volume: 42, P: 504-513
DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia

Christoph Plass, Christopher Oakes and colleagues study genome-wide DNA methylation dynamics during B cell maturation and the pathogenic role of transcription factor dysregulation in chronic lymphocytic leukemia (CLL). By comparing normal and malignant B cells, they find that tumors derive from a continuum of maturation states, which correlate with different clinical outcomes.

Christopher C Oakes
Marc Seifert
Christoph Plass
Research18 Jan 2016
Nature Genetics

Volume: 48, P: 253-264
DNA polymerases in adaptive immunity

The development of a diverse B-cell repertoire depends on genetic rearrangement and hypermutation at the B-cell receptor (BCR) loci. This Review describes which DNA polymerases might be involved in these DNA transactions and therefore contribute to BCR diversity.

Jean-Claude Weill
Claude-Agnès Reynaud
Reviews14 Mar 2008
Nature Reviews Immunology

Volume: 8, P: 302-312
Comparison of translucency, thickness, and gap width of thermoformed and 3D-printed clear aligners using micro-CT and spectrophotometer

So Yeon Park
Sung-Hwan Choi
Jung-Yul Cha
ResearchOpen Access05 Jul 2023
Scientific Reports

Volume: 13, P: 1-10
Long-term depression at hippocampal mossy fiber-CA3 synapses involves BDNF but is not mediated by p75NTR signaling

Machhindra Garad
Elke Edelmann
Volkmar Leßmann
ResearchOpen Access20 Apr 2021
Scientific Reports

Volume: 11, P: 1-14
Meiotic arrest and aneuploidy in MLH3-deficient mice

Steven M. Lipkin
Peter B. Moens
Paula E. Cohen
Research01 Jul 2002
Nature Genetics

Volume: 31, P: 385-390
EFFECT OF (Sar¹, Ile⁸)-ANGIOTENSIN II INHIBITOR ON GLOMERULAR FILTRATION AND RENAL PLASMA FLOW IN THE FETAL LAMB

E S Moore
J B Paton
E C Lyons
Research01 Apr 1974
Pediatric Research

Volume: 8, P: 459
LATE-ONSET NEPHROPATHIC CYSTINOSIS WITH MASSIVE PROTEINURIA. A STUDY OF THE RENAL LESIONS AND TUBULAR FUNCTIONS

Rufino C Pabico
Michael F Bryson
Gilbert B Forbes
Research01 Apr 1974
Pediatric Research

Volume: 8, P: 459
HYPERTENSION IN INFANTS

Lauren B Plumer
George W Kaplan
Stanley A Mendoza
Research01 Apr 1974
Pediatric Research

Volume: 8, P: 459
PLASMA RENIN ACTIVITY (PRA) IN THE ASSESSMENT OF PERSISTENT HYPERTENSION (HT) OF RENAL ALLOGRAFT RECIPIENTS

A Hsu
J Balfe
Donald Fraser
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 552
Symmetry of gamma distribution data about the mean after processing with EWMA function

Mohammad M. Hamasha
Mohammed S. Obeidat
Adnan Mukkatash
ResearchOpen Access12 Sept 2023
Scientific Reports

Volume: 13, P: 1-13
THE NORMAL ASPIRATION OF AMNIOTIC FLUID BY THE CONCEPTUS

Lily Yuan
Anita Perricelli
David Gitlin
Research01 Apr 1974
Pediatric Research

Volume: 8, P: 453
PARATHYROID HORMONE REGULATION IN CHILDREN WITH CHRONIC RENAL DISEASE

Alan B Gruskin
Allen W Root
H Jorge Baluarter
Research01 Apr 1974
Pediatric Research

Volume: 8, P: 455
Familial nephrotic syndrocalcinosis and tubular dysfunction

Edmund C Burke
Gunnar B Stickler
Ladislav P Novak
Research01 Aug 1971
Pediatric Research

Volume: 5, P: 383
Nocturnal Enuresis: Correlation with Bacteriuria, Proteinuria and Dysuria

Warren F Dodge
Evelyn F West
Luther B Travis
Research01 Sept 1970
Pediatric Research

Volume: 4, P: 450
GLOMERULAR SIALIC ACID IN PROTEIN OVERLOAD PROTEINURIA

Edward B Blau
Rebecca L Felt
Research01 Apr 1974
Pediatric Research

Volume: 8, P: 453
Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome

The generation of induced pluripotent stem cells (iPSCs) from patients with defined genetic disorders promises to help the basic understanding of complex diseases and the development of therapeutics. Here iPSCs have been generated from patients with LEOPARD syndrome, a developmental disorder with pleiomorphic effects on several tissues and organs. The iPSCs are characterized and the phenotype of cardiomyocytes derived from these cells is investigated.

Xonia Carvajal-Vergara
Ana Sevilla
Ihor R. Lemischka
Research10 Jun 2010
Nature

Volume: 465, P: 808-812
Lipoprotein(a) Serum Levels and Apolipoprotein(a) Phenotypes in Children with Chronic Renal Disease

U Querfeld
M Lang
K Schärer
Research01 Dec 1993
Pediatric Research

Volume: 34, P: 772-776
Plasma selenoprotein P levels of healthy males in different selenium status after oral supplementation with different forms of selenium

M Persson-Moschos
G Alfthan
B Åkesson
Research05 May 1998
European Journal of Clinical Nutrition

Volume: 52, P: 363-367
Effects of spironolactone on exercise blood pressure in patients at increased risk of developing heart failure: report from the HOMAGE trial

Fang-Fei Wei
Pierpaolo Pellicori
Faiez Zannad
ResearchOpen Access06 Sept 2024
Hypertension Research

Volume: 47, P: 3225-3236

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