Nature Search

Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

A pan-cancer genomic analysis reports the effects of structural variations on chromatin domains (TADs). Most TAD disruptions do not result in appreciable changes in expression of nearby genes.

Kadir C. Akdemir
Victoria T. Le
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 294-305
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig

Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

Yulia Rubanova
Ruian Shi
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-12
Pathway and network analysis of more than 2500 whole cancer genomes

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

Matthew A. Reyna
David Haan
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-17
Patterns of somatic structural variation in human cancer genomes

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Yilong Li
Nicola D. Roberts
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature

Volume: 578, P: 112-121
Structural basis of kynurenine 3-monooxygenase inhibition

Inhibition of kynurenine 3-monooxygenase (KMO) leads to amelioration of Huntington’s-disease-relevant phenotypes in yeast, fruitfly and mouse models; here the crystal structures of free and inhibitor-bound yeast KMO are presented, which could aid the development of targeted therapies for human neurodegenerative diseases.

Marta Amaral
Colin Levy
Nigel S. Scrutton
Research10 Apr 2013
Nature

Volume: 496, P: 382-385
The landscape of viral associations in human cancers

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

Marc Zapatka
Ivan Borozan
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 320-330
Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus

Oliver Leske
Christian Kaltschmidt
Hendrikje Werner
ResearchOpen Access05 Jul 2011
Nature Precedings

P: 1
Use of Pyridine in the De-ionization of Solutions for Paper Chromatography

F. H. MALPRESS
A. B. MORRISON
Research03 Dec 1949
Nature

Volume: 164, P: 963
Scaling of sensory information in large neural populations shows signatures of information-limiting correlations

Information regarding a sensory stimulus is distributed in activity of neuronal populations. Here the authors show stimulus information scales sub-linearly with the number of neurons in mouse visual cortex due to correlated noise and may saturate in far fewer numbers of neurons than the total in V1.

MohammadMehdi Kafashan
Anna W. Jaffe
Jan Drugowitsch
ResearchOpen Access20 Jan 2021
Nature Communications

Volume: 12, P: 1-16
The Cyclotron Unit: Medical Research Council

D. D. VONBERG
J. F. FOWLER
Research01 Jun 1963
Nature

Volume: 198, P: 827-832
Migration-elution of Zones in an Electrophoresis Column

J. PORATH
E. B. LINDNER
S. JERSTEDT
Research13 Sept 1958
Nature

Volume: 182, P: 744-745
High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

Barbara L. Hempstead
Dionisio Martin-Zanca
Moses V. Chao
Research25 Apr 1991
Nature

Volume: 350, P: 678-683
220 MHz Nuclear Magnetic Resonance Spectra of High Density Serum Lipoproteins

D. CHAPMAN
R. B. LESLIE
A. M. SCANU
Research18 Jan 1969
Nature

Volume: 221, P: 260-261
Leptin receptor⁺ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor

Gao et al. report that leptin receptor⁺ stromal cells sustain nerves in the bone marrow by producing nerve growth factor. After myeloablation, nerves promote marrow regeneration by increasing the production of multiple growth factors by leptin receptor⁺ cells.

Xiang Gao
Malea M. Murphy
Sean J. Morrison
ResearchOpen Access27 Nov 2023
Nature Cell Biology

Volume: 25, P: 1746-1757
A Second Example of – – –/– – – Blood or Rh_null

PHILIP LEVINE
M. J. CELANO
CAROL T. ENGLISH
Research28 Nov 1964
Nature

Volume: 204, P: 892-893
Sex differences in oncogenic mutational processes

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

Constance H. Li
Stephenie D. Prokopec
Christian von Mering
ResearchOpen Access28 Aug 2020
Nature Communications

Volume: 11, P: 1-24
Are physiological oxygen concentrations mutagenic?

WALTER J. BRUYNINCKX
HOWARD S. MASON
STEPHEN A. MORSE
Research10 Aug 1978
Nature

Volume: 274, P: 606-607
Temperature and Habituation in a Protozoan

PHILIP B. APPLEWHITE
Research06 Jul 1968
Nature

Volume: 219, P: 91-92
Electric field-induced flame convection in the absence of gravity

F. B. Carleton
F. J. Weinberg
Research23 Dec 1987
Nature

Volume: 330, P: 635-636
Integrative pathway enrichment analysis of multivariate omics data

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Marta Paczkowska
Jonathan Barenboim
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-16
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations

In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

Yiqun Zhang
Fengju Chen
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-14
Thrombin and epidermal growth factor become linked to cell surface receptors during mitogenic stimulation

JOFFRE B. BAKER
ROBERT L. SIMMER
DENNIS D. CUNNINGHAM
Research01 Apr 1979
Nature

Volume: 278, P: 743-745
The Smallest Diplodocid Skull Reveals Cranial Ontogeny and Growth-Related Dietary Changes in the Largest Dinosaurs

D. Cary Woodruff
Thomas D. Carr
John P. Wilson
ResearchOpen Access11 Oct 2018
Scientific Reports

Volume: 8, P: 1-12
Antigenic drift between the haemagglutinin of the Hong Kong influenza strains A/Aichi/2/68 and A/Victoria/3/75

Martine Verhoeyen
Rongxiang Fang
Walter Fiers
Research01 Aug 1980
Nature

Volume: 286, P: 771-776
The potential for coral reef restoration to mitigate coastal flooding as sea levels rise

The capacity of coral reefs to keep pace with sea-level rise is central to their ability to continue to provide shoreline protection to vulnerable coastal communities. Here, the study shows that whereas restoration has the potential to minimize climate-change impacts, doing nothing will amplify them.

Lauren T. Toth
Curt D. Storlazzi
Richard B. Aronson
ResearchOpen Access21 Apr 2023
Nature Communications

Volume: 14, P: 1-13
Spectral evidence for sublimates and adsorbates on Io

The reflectance spectrum of Io can be explained by a surface layer consisting of fine-grained particles of sublimated alkali sulphides and sulphur on which H₂S and SO₂ are adsorbed.

Douglas B. Nash
Robert M. Nelson
News & Views30 Aug 1979
Nature

Volume: 280, P: 763-766
Detection of Actomyosin-type Protein at the Surface of Dissociated Embryonic Chick Cells

UTE GRÖSCHEL-STEWART
BRYN M. JONES
RICHARD B. KEMP
Research18 Jul 1970
Nature

Volume: 227, P: 280
NF-κB inducing kinase is a therapeutic target for systemic lupus erythematosus

Clinical trials of BAFF blockade with belimumab have shown partial efficacy for the treatment of systemic lupus erythematosus (SLE), so other therapeutic options are required. Here, the authors present a new small molecule inhibitor that targets NIK with a similar efficacy to BAFF inhibition in two mouse models of SLE.

Hans D. Brightbill
Eric Suto
Nico Ghilardi
ResearchOpen Access12 Jan 2018
Nature Communications

Volume: 9, P: 1-14
Activation and repression of transcription by homoeodomain-containing proteins that bind a common site

James B. Jaynes
Patrick H. O'Farrell
Research29 Dec 1988
Nature

Volume: 336, P: 744-749
Bird population declines and species turnover are changing the acoustic properties of spring soundscapes

Birdsong has long connected humans to nature. Historical reconstructions using bird monitoring and song recordings collected by citizen scientists reveal that the soundscape of birdsong in North America and Europe is both quieter and less varied, mirroring declines in bird diversity and abundance.

C. A. Morrison
A. Auniņš
S. J. Butler
ResearchOpen Access02 Nov 2021
Nature Communications

Volume: 12, P: 1-12
Simian virus 40 facilitates multiplication of replication defective mutants of polyoma virus in BALB/3T3 mouse cells

AKIRA HAKURA
Research09 Jun 1977
Nature

Volume: 267, P: 528-529
Influenza Antibody in Human Respiratory Secretions after Subcutaneous or Respiratory Immunization with Inactivated Virus

ROBERT H. WALDMAN
JULIUS A. KASEL
JOHN J. MANN
Research01 May 1968
Nature

Volume: 218, P: 594-595
Genomic footprints of activated telomere maintenance mechanisms in cancer

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

Lina Sieverling
Chen Hong
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-13
CD22 regulates thymus-independent responses and the lifespan of B cells

Kevin L. Otipoby
Kristin B. Andersson
Edward A. Clark
Research26 Dec 1996
Nature

Volume: 384, P: 634-637
Unexpected Dose-rate Effect in the Killing of Mice by Radiation

SHIRLEY HORNSEY
TIKVAH ALPER
Research09 Apr 1966
Nature

Volume: 210, P: 212-213
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

Wei Jiao
Gurnit Atwal
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Communications

Volume: 11, P: 1-12
Thinning of the Human Cornea on Awakening

R. B. MANDELL
I. FATT
Research16 Oct 1965
Nature

Volume: 208, P: 292-293
Sigma Phase in Vanadium–Nickel Alloys

W. B. PEARSON
J. W. CHRISTIAN
Research12 Jan 1952
Nature

Volume: 169, P: 70-71
A model for the molecular requirements of immunoglobulin heavy chain class switching

Kenneth B. Marcu
Rhonda B. Lang
Linda J. Harris
Research01 Jul 1982
Nature

Volume: 298, P: 87-89
Ribosidation of 4-Amino-imidazole-5-carboxamide by Escherichia coli

R. BEN-ISHAI
ERNST D. BERGMANN
B. E. VOLCANI
Research29 Dec 1951
Nature

Volume: 168, P: 1124
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Motor deficit and impairment of synaptic plasticity in mice lacking mGluR1

François Conquet
Zafar I. Bashir
Francis Crépel
Research17 Nov 1994
Nature

Volume: 372, P: 237-243
Effect of Chloramphenicol in maintaining the Viability of Escherichia coli

R. B. MORRISON
SAMIHA EL BAGOURY
S. FLETCHER
Research29 Dec 1956
Nature

Volume: 178, P: 1467
Dr. T. Richards

B. C. J. G. KNIGHT
Comments & Opinion09 Jun 1956
Nature

Volume: 177, P: 1060-1061
Inhibition of Oxygen Consumption of Liver Homogenates from Mice injected with Radioprotectors in the Presence of Pyruvate

P. CICCARONE
Z. M. BACQ
Research07 May 1966
Nature

Volume: 210, P: 648-649
A control oriented strategy of disruption prediction to avoid the configuration collapse of tokamak reactors

Confining plasma and managing disruptions in tokamak devices is a challenge. Here the authors demonstrate a method predicting and possibly preventing disruptions and macroscopic instabilities in tokamak plasma using data from JET.

Andrea Murari
Riccardo Rossi
Michela Gelfusa
ResearchOpen Access18 Mar 2024
Nature Communications

Volume: 15, P: 1-19
Thermal Transformations of the Aluminas and their Hydrates

MARGARET K. B. DAY
VERNON J. HILL
Research27 Sept 1952
Nature

Volume: 170, P: 539
Carbonatite origin and diversity

B. KJARSGAARD
D. L. HAMILTON
Research13 Apr 1989
Nature

Volume: 338, P: 547-548
Auxin-induced Reversal of Geotropic Response in Onion Seedlings

B. M. JOHRI
SIPRA GUHA
S. C. MAHESHWARI
Research01 Mar 1965
Nature

Volume: 205, P: 1026-1027

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