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Nature of Humic Acids

ALAN BURGES
H. M. HURST
M. HIRST
Research17 Aug 1963
Nature

Volume: 199, P: 696-697
Genomically matched therapy in advanced solid tumors: the randomized phase 2 ROME trial

In the proof-of-concept phase 2 ROME trial, comprehensive genomic profiling followed by molecular tumor board evaluation and randomization of patients with metastatic solid cancer to receive personalized therapy or standard of care led to a significantly higher objective response rate and longer progression-free survival in patients who received personalized therapy.

Paolo Marchetti
Giuseppe Curigliano
Francesca Mannozzi
ResearchOpen Access29 Sept 2025
Nature Medicine

P: 1-10
Mitochondrial implication in apoptosis. Towards an endosymbiont hypothesis of apoptosis evolution

Guido Kroemer
Reviews01 Aug 1997
Cell Death & Differentiation

Volume: 4, P: 443-456
The Striped Marlin (Makaira audax Phillipi) in South Africa

J. L. B. SMITH
Research21 Apr 1956
Nature

Volume: 177, P: 758
Early–middle Permian Mediterranean gorgonopsian suggests an equatorial origin of therapsids

Gorgonopsians were sabre toothed therapsids, a group that is ancestral to mammals. The authors here describe a gorgonopsian from the early–middle Permian of Mallorca, suggesting that therapsids originated in tropical regions and diversified quickly over 10 million years.

Rafel Matamales-Andreu
Christian F. Kammerer
Josep Fortuny
ResearchOpen Access17 Dec 2024
Nature Communications

Volume: 15, P: 1-12
Sequestration of C0₂ in the deep ocean by shallow injection

Peter M. Haugan
Helge Drange
Research28 May 1992
Nature

Volume: 357, P: 318-320
Effect of Orotic Acid on Activity of Nuclear DNA-dependent RNA Polymerase and Polyribosomal Profiles in Deficient Chick Liver lacking Vitamin B₁₂

C. M. CALDARERA
B. BARBIROLI
M. MARCHETTI
Research24 Feb 1968
Nature

Volume: 217, P: 755-756
The E5 protein of BPV-4 interacts with the heavy chain of MHC class I and irreversibly retains the MHC complex in the Golgi apparatus

B Marchetti
G H Ashrafi
M S Campo
Research14 Nov 2005
Oncogene

Volume: 25, P: 2254-2263
Finite-temperature phase diagram of a polarized Fermi condensate

M. M. Parish
F. M. Marchetti
B. D. Simons
Research28 Jan 2007
Nature Physics

Volume: 3, P: 124-128
Ramp length/grade prescriptions for wheelchair dependent individuals

I Canale
F Felici
B Ricci
Research01 Sept 1991
Spinal Cord

Volume: 29, P: 479-485
Morphometric and neurophysiological analysis of skeletal muscle in paraplegic patients with traumatic cord lesion

S Lotta
R Scelsi
U Carraro
Research01 May 1991
Spinal Cord

Volume: 29, P: 247-252
Skeletal muscle changes following myelotomy in paraplegic patients

R Scelsi
P Poggi
A Saitta
Research01 Aug 1986
Spinal Cord

Volume: 24, P: 250-259
Prediction of Survival in Stage I Lung Carcinoma Patients by Telomerase Function Evaluation

Antonio Marchetti
Caterina Pellegrini
Silvano Bosari
Research01 Jun 2002
Laboratory Investigation

Volume: 82, P: 729-736
Vasopressin excites hippocampal neurones

M. Mühlethaler
J. J. Dreifuss
B. H. Gähwiler
Research22 Apr 1982
Nature

Volume: 296, P: 749-751
Bone marrow microenvironment in autoimmune hemolytic anemia: from trephine biopsy to single cell RNA sequencing

Bruno Fattizzo
Matteo Claudio Da Vià
Wilma Barcellini
ResearchOpen Access25 Aug 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-11
Large bipolaron density at organic semiconductor/electrode interfaces

Bipolarons - two electrons or holes localized on the same molecule - are generally considered negligible in organic electronic devices. Dhanker et al. show that large bipolaron densities can exist near electrode interfaces and that they are linked to the phenomenon of unipolar organic magnetoresistance.

Rijul Dhanker
Christopher L. Gray
Noel C. Giebink
ResearchOpen Access21 Dec 2017
Nature Communications

Volume: 8, P: 1-7
Golgi membrane fission requires the CtBP1-S/BARS-induced activation of lysophosphatidic acid acyltransferase δ

CtBP1-S/BARS is required for fission of endomembrane compartments including the Golgi. Here the authors show that CtBP1-S/BARS activates a trans-Golgi lysophosphatidic acid acyltransferase that catalyses the production of phosphatidic acid and is required for fission of the post-Golgi carrier membrane.

Alessandro Pagliuso
Carmen Valente
Alberto Luini
ResearchOpen Access12 Jul 2016
Nature Communications

Volume: 7, P: 1-15
Prediction of ramp traversability for wheelchair dependent individuals

A Cappozzo
F Felici
B Ricci
Research01 Sept 1991
Spinal Cord

Volume: 29, P: 470-478
Presence and possible significance of immunohistochemically demonstrable prolactin in breast apocrine metaplasia

S Kumar
RE Mansel
B Jasani
Research01 Mar 1987
British Journal of Cancer

Volume: 55, P: 307-309
Large-scale eradication of rabies using recombinant vaccinia-rabies vaccine

B. Brochier
M. P. Kieny
P.-P. Pastoret
Research26 Dec 1991
Nature

Volume: 354, P: 520-522
Functional genetics reveals the contribution of delta opioid receptor to type 2 diabetes and beta-cell function

Opioid use impacts metabolic homeostasis, although the mechanisms remain elusive. Here, the authors explore the OPRD1 gene (encoding the delta opioid receptor, DOP) to understand its impact on type 2 diabetes and highlight DOP as a key player between opioids and metabolic homeostasis.

Sarah Meulebrouck
Judith Merrheim
Amélie Bonnefond
ResearchOpen Access05 Aug 2024
Nature Communications

Volume: 15, P: 1-12
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section

M. Sendtner
B. Holtmann
Y.-A. Barde
Research31 Dec 1992
Nature

Volume: 360, P: 757-759
Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4

J. C. Conover
J. T. Erickson
G. D. Yancopoulos
Research18 May 1995
Nature

Volume: 375, P: 235-238
Prospective multicenter study using artificial intelligence to improve dermoscopic melanoma diagnosis in patient care

Heinlein, Maron, Hekler et al. evaluate an AI algorithm for detecting melanoma and compare its performance to that of dermatologist on a prospectively collected, external, heterogeneous dataset. The AI exhibits a significant performance advantage, especially in diagnosing challenging cases.

Lukas Heinlein
Roman C. Maron
Titus J. Brinker
ResearchOpen Access11 Sept 2024
Communications Medicine

Volume: 4, P: 1-9
IL-4 inhibits apoptosis and prevents mitochondrial damage without inducing the switch to necrosis observed with caspase inhibitors

Christophe Lemaire
Karine Andréau
Vongthip Souvannavong
Research27 Aug 1999
Cell Death & Differentiation

Volume: 6, P: 813-820
TRPC3 shapes the ER-mitochondria Ca²⁺ transfer characterizing tumour-promoting senescence

Mitochondrial Ca2+ homeostasis is reported to influence cellular senescence. Here the authors show that TRPC3 limits senescence by inhibiting IP3R-mediated Ca2+ release and ER mitochondria Ca2+ transfer and that the downregulation of TRPC3 in stromal cells affects SASP production and tumour progression.

Valerio Farfariello
Dmitri V. Gordienko
Natalia Prevarskaya
ResearchOpen Access17 Feb 2022
Nature Communications

Volume: 13, P: 1-18
Inorganic carbon uptake in hydrothermal vent tubeworms facilitated by high environmental pC0₂

James J. Childress
Raymond W. Lee
James Brooks
Research11 Mar 1993
Nature

Volume: 362, P: 147-149
Polyoma Virus-induced Release of inhibition of Cellular DNA Synthesis caused by Iododeoxyuridine

AKIKO KASAMAKI
TAMAR BEN-PORAT
ALBERT S. KAPLAN
Research24 Feb 1968
Nature

Volume: 217, P: 756-758
A circular RNA generated from an intron of the insulin gene controls insulin secretion

Circular RNAs contribute to the regulation of β-cell specific functions. Here the authors show that a circular RNA derived from one of the introns of the insulin gene is necessary for optimal insulin secretion from pancreatic islets and that its level is reduced in the islets of diabetic subjects.

Lisa Stoll
Adriana Rodríguez-Trejo
Romano Regazzi
ResearchOpen Access05 Nov 2020
Nature Communications

Volume: 11, P: 1-13
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

Dinesh Aggarwal
Ben Warne
Ian G. Goodfellow
ResearchOpen Access08 Feb 2022
Nature Communications

Volume: 13, P: 1-16
The decline and fate of an iron-induced subarctic phytoplankton bloom

Philip W. Boyd
Cliff S. Law
Takeshi Yoshimura
Research17 Mar 2004
Nature

Volume: 428, P: 549-553
Concerns about reported harvests in European forests

Marc Palahí
Rubén Valbuena
Gert-Jan Nabuurs
Research28 Apr 2021
Nature

Volume: 592, P: E15-E17
Decline in plankton diversity and carbon flux with reduced sea ice extent along the Western Antarctic Peninsula

Over the past century, the Western Antarctic Peninsula has experienced rapid warming and a substantial loss of sea ice with important implications for plankton biodiversity and carbon cycling. Using a 5-year DNA metabarcoding dataset, this study assesses how interannual variability in sea-ice conditions impacts biodiversity and biological carbon fluxes in this region.

Yajuan Lin
Carly Moreno
Nicolas Cassar
ResearchOpen Access16 Aug 2021
Nature Communications

Volume: 12, P: 1-9
Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin

T Shonukan
I Bagayogo
B Hempstead
Research05 Jun 2003
Oncogene

Volume: 22, P: 3616-3623
Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia

Candidaemia is a common cause of bloodstream infection, but the genetic basis of Candidainfection is poorly understood. Here, the authors identify genetic variation at three loci that increase risk of candidaemia, and show that genes at these loci have a role in antifungal host defence.

Vinod Kumar
Shih-Chin Cheng
Mihai G. Netea
Research08 Sept 2014
Nature Communications

Volume: 5, P: 1-8
Non-natives: plusses of invasion ecology

Julie L. Lockwood
Martha F. Hoopes
Michael P. Marchetti
Correspondence06 Jul 2011
Nature

Volume: 475, P: 36
LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus

Type 1 diabetes mellitus (T1DM) is characterized by beta cell loss because of an autoimmune attack. Here the authors show that an agonist for LRH-1/NR5A2, a nuclear receptor known to be protective against beta cell apoptosis, inhibits immune-mediated inflammation and hyperglycemia in T1DM mouse models.

Nadia Cobo-Vuilleumier
Petra I. Lorenzo
Benoit R. Gauthier
ResearchOpen Access16 Apr 2018
Nature Communications

Volume: 9, P: 1-15
Multi-layered deep immune profiling, SARS-CoV-2 RNAemia and inflammation in unvaccinated COVID-19 individuals with persistent symptoms

Rovito et al. conduct deep immune profiling of hospitalized and unvaccinated individuals with persistent symptoms three months post COVID-19. They explore the role of SARS-CoV-2 RNAemia and peripheral inflammation in driving immune dysregulation, finding impaired responses in the humoral arm partially linked to RNAemia.

Roberta Rovito
Valeria Bono
Giulia Marchetti
ResearchOpen Access05 May 2025
Communications Medicine

Volume: 5, P: 1-15
Impaired viral infection and reduced mortality of diatoms in iron-limited oceanic regions

Diatoms are less susceptible to viral infection in iron-limited oceans, according to metatranscriptomic analyses of diatoms and viruses in nutrient-replete and limited regions.

Chana F. Kranzler
Mark A. Brzezinski
Kimberlee Thamatrakoln
Research01 Apr 2021
Nature Geoscience

Volume: 14, P: 231-237
Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells

Cells respond to increasing concentrations of EGF by altering the balance between EGFR phosphorylation and ubiquitination. Here the authors show that the establishment of an EGFR signaling threshold requires both a multiplicity of binding sites and cooperative binding of Cbl and Grb2 to the EGFR.

Fabrizio Capuani
Alexia Conte
Andrea Ciliberto
ResearchOpen Access12 Aug 2015
Nature Communications

Volume: 6, P: 1-14
Curvature induces active velocity waves in rotating spherical tissues

The existence of multicellular systems relies on coordinated cell motion in three dimensions. Here, cell migration in rotating spherical tissues is shown to exhibit a collective mode with a single-wavelength velocity wave, which arises from the effect of curvature on the flocking behavior of cells on a spherical surface.

Tom Brandstätter
David B. Brückner
Chase P. Broedersz
ResearchOpen Access24 Mar 2023
Nature Communications

Volume: 14, P: 1-11
An integrated multi-omics approach identifies the landscape of interferon-α-mediated responses of human pancreatic beta cells

The cytokine IFNα is expressed in the islets of individuals with type 1 diabetes and contributes to local inflammation and destruction of beta cells. Here, the authors provide a global multiomics view of IFNα-induced changes in human beta cells at the level of chromatin, mRNA and protein expression.

Maikel L. Colli
Mireia Ramos-Rodríguez
Décio L. Eizirik
ResearchOpen Access22 May 2020
Nature Communications

Volume: 11, P: 1-17
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes

Cytokine-induced regulatory changes in human pancreatic islets illustrate the β-cell chromatin dynamics in response to a proinflammatory environment and implicate a role for islet enhancers in type 1 diabetes.

Mireia Ramos-Rodríguez
Helena Raurell-Vila
Lorenzo Pasquali
Research01 Nov 2019
Nature Genetics

Volume: 51, P: 1588-1595
Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function

Glycogen Synthase Kinase 3 (GSK3) has conserved functions across species but its role in the kidney is unclear. Here, the authors show that in the kidney podocyte cell of mice and related nephrocyte in Drosophila that GSK3 is a master regulator of function both during development and in maturity.

J. A. Hurcombe
P. Hartley
R. J. M. Coward
ResearchOpen Access24 Jan 2019
Nature Communications

Volume: 10, P: 1-17
Leader β-cells coordinate Ca²⁺ dynamics across pancreatic islets in vivo

Pancreatic β-cells are highly connected, and this network is crucial for the pulsatile release of insulin. Here Salem and colleagues demonstrated the existence of leader β-cells that respond first to glucose and are more closely linked to the other β-cells. They also showed that glucose increases β-cell calcium dynamics and connectivity between the leader and non-leader β-cells.

Victoria Salem
Luis Delgadillo Silva
Guy A. Rutter
Research14 Jun 2019
Nature Metabolism

Volume: 1, P: 615-629
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome

Karen Hsiao
Harry F. Baker
Stanley B. Prusiner
Research23 Mar 1989
Nature

Volume: 338, P: 342-345
Coexistence of EGFR with KRAS, or BRAF, or PIK3CA somatic mutations in lung cancer: a comprehensive mutation profiling from 5125 Chinese cohorts

S Li
L Li
N Liang
ResearchOpen Access17 Apr 2014
British Journal of Cancer

Volume: 110, P: 2812-2820
Evolutionary trends and phylogenetic association of key morphological traits in the Italian rice varietal landscape

Gabriele Mongiano
Patrizia Titone
Simone Bregaglio
ResearchOpen Access11 Sept 2018
Scientific Reports

Volume: 8, P: 1-12
Bose–Einstein condensation of exciton polaritons

This paper presents a comprehensive set of experiments in which polaritons are excited in a semiconductor microcavity. Above a critical density of polaritons, massive occupation of the ground state at 19 K is observed and various pieces of experimental evidence point to a spontaneous onset of a macroscopic quantum phase.

J. Kasprzak
M. Richard
Le Si Dang
Research28 Sept 2006
Nature

Volume: 443, P: 409-414

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