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Showing 151–200 of 372 results

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In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer

Here, the authors use genome-scale in vivo CRISPR screens to look at immune evasion mechanisms across cancer models, showing that IFN-mediated upregulation of classical and non-classical MHC class I inhibitory checkpoints facilitate immune escape.

Juan Dubrot
Peter P. Du
Robert T. Manguso
Research23 Sept 2022
Nature Immunology

Volume: 23, P: 1495-1506
Exome-wide association study of plasma lipids in >300,000 individuals

Exome-wide genetic analysis on >300,000 individuals identifies associations with plasma lipid traits. Loci significantly associated with cholesterol and triglycerides are examined together to determine the effects of alleles on type 2 diabetes and coronary artery disease risk.

Dajiang J Liu
Gina M Peloso
Sekar Kathiresan
Research30 Oct 2017
Nature Genetics

Volume: 49, P: 1758-1766
Allergic rhinitis is associated with thromboembolic disease in pregnancy

Chia-Ta Wu
Chien-Han Tsao
Min-Sho Ku
ResearchOpen Access04 May 2022
Scientific Reports

Volume: 12, P: 1-7
The proto-oncogene c-fos increases the sensitivity of keratinocytes to apoptosis

Valérie Mils
Jacques Piette
Nicole Basset-Séguin
Research03 Apr 1997
Oncogene

Volume: 14, P: 1555-1561
Targeting of lipid metabolism with a metabolic inhibitor cocktail eradicates peritoneal metastases in ovarian cancer cells

Rain Chen et al. show that lipid metabolism is highly active in ovarian cancer cells in an ascites microenvironment, causing increased aggressiveness. They show that combined treatment of AMPK activators and TAK1/FASN inhibitors could impair ovarian cancer peritoneal metastasis.

Rain R. Chen
Mingo M. H. Yung
David W. Chan
ResearchOpen Access31 Jul 2019
Communications Biology

Volume: 2, P: 1-15
Effects of Nitrate on Fermentation of Xylose and Glucose by Pachysolen Tannophilus

Thomas W. Jeffries
Research01 Aug 1983
Bio/Technology

Volume: 1, P: 503-506
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

Christopher Amos and colleagues perform genome-wide association analysis for lung cancer using cohorts genotyped on the OncoArray and combing these with existing data. They identify 18 loci, 10 of which are new, finding heterogeneity across the different lung cancer subtypes, and explore candidate genes through eQTL analysis in lung tissue.

James D McKay
Rayjean J Hung
Christopher I Amos
Research12 Jun 2017
Nature Genetics

Volume: 49, P: 1126-1132
Fibroblasts in metastatic lymph nodes confer cisplatin resistance to ESCC tumor cells via PI16

Lily Liang
Xu Zhang
Yan Li
ResearchOpen Access01 Nov 2023
Oncogenesis

Volume: 12, P: 1-12
Morphing electronics enable neuromodulation in growing tissue

Viscoplastic electronic devices adapt as nerves enlarge in growing animals.

Yuxin Liu
Jinxing Li
Zhenan Bao
Research20 Apr 2020
Nature Biotechnology

Volume: 38, P: 1031-1036
Activation of the EGFR/ERK pathway in high-grade mucoepidermoid carcinomas of the salivary glands

B Lujan
S Hakim
L Alos
ResearchOpen Access27 Jul 2010
British Journal of Cancer

Volume: 103, P: 510-516
Predicting toxicity-related docetaxel discontinuation and overall survival in metastatic castration-resistant prostate cancer: a pooled analysis of open phase 3 clinical trial data

Alberto Martini
Anish B. Parikh
Che-Kai Tsao
Research02 Feb 2021
Prostate Cancer and Prostatic Diseases

Volume: 24, P: 743-749
Genetic predisposition to ocular melanoma

R S Houlston
B E Damato
Research01 Jan 1999
Eye

Volume: 13, P: 43-46
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus

Patrick Gaffney and colleagues perform a fine-mapping study of the TNFAIP3 region in systemic lupus erythematosus using individuals from diverse ancestral populations. They identify a putative causal variant in a region of high conservation and regulatory potential that is associated with reduced TNFAIP3 expression.

Indra Adrianto
Feng Wen
Patrick M Gaffney
Research20 Feb 2011
Nature Genetics

Volume: 43, P: 253-258
A first update on mapping the human genetic architecture of COVID-19

Gita A. Pathak
Juha Karjalainen
J. Kenneth Baillie
ResearchOpen Access03 Aug 2022
Nature

Volume: 608, P: E1-E10
Heterogeneous associations between interleukin-6 receptor variants and phenotypes across ancestries and implications for therapy

Xuan Wang
Molei Liu
Katherine P. Liao
ResearchOpen Access05 Apr 2024
Scientific Reports

Volume: 14, P: 1-12
THE MOLECULAR BASIS FOR THE HEREDITARY OVERPRODUCTION OF ADENOSINE DEAMINASE: 32

Elaine G Chottiner
T Eng Gan
Beverly S Mitchell
Research01 Jul 1985
Pediatric Research

Volume: 19, P: 749
Repurposing dextromethorphan and metformin for treating nicotine-induced cancer by directly targeting CHRNA7 to inhibit JAK2/STAT3/SOX2 signaling

Lu Wang
Liang Du
Hao Zhang
ResearchOpen Access18 Feb 2021
Oncogene

Volume: 40, P: 1974-1987
The genetics of systemic lupus erythematosus: putting the pieces together

J A Kelly
K L Moser
J B Harley
Research06 Sept 2002
Genes & Immunity

Volume: 3, P: S71-S85
Metabolic reprogramming of ovarian cancer involves ACSL1-mediated metastasis stimulation through upregulated protein myristoylation

Qingyu Zhang
Wei Zhou
Leo Tsz On Lee
Research20 Oct 2020
Oncogene

Volume: 40, P: 97-111
Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

Praveen Surendran
Elena V. Feofanova
Joanna M. M. Howson
Amendments and Corrections16 Mar 2021
Nature Genetics

Volume: 53, P: 762
Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Amendments and Corrections26 May 2023
Nature

Volume: 618, P: E19-E20
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

John B Harley
Marta E Alarcón-Riquelme
Carl D Langefeld
Research20 Jan 2008
Nature Genetics

Volume: 40, P: 204-210
ATP IN OXIDANT-INDUCED TISSUE INJURY: 35

Charles G Cochrane
Ingrid U Schraufstätter
Larry A Sklar
Research01 Jul 1985
Pediatric Research

Volume: 19, P: 749
FGF8b oncogene mediates proliferation and invasion of Epstein–Barr virus-associated nasopharyngeal carcinoma cells: implication for viral-mediated FGF8b upregulation

V W Y Lui
D M-S Yau
A T C Chan
Research29 Nov 2010
Oncogene

Volume: 30, P: 1518-1530
Colonic crypt organization and tumorigenesis

Recent advances in our understanding of intestinal crypt biology, including how mutations in stem cells become fixed and expand within the epithelium, has led to new theories on the origins of colonic adenomas and cancers.

Adam Humphries
Nicholas A. Wright
Reviews15 May 2008
Nature Reviews Cancer

Volume: 8, P: 415-424
Identification of influenza A nucleoprotein as an antiviral target

The spread of influenza virus strains resistant to the current generation of anti-viral drugs makes the identification of new druggable targets and lead compounds of prime importance. Kao et al. show that the influenza A nucleoprotein can be targeted by a small molecule that protects mice from lethal viral challenges.

Richard Y Kao
Dan Yang
Kwok-Yung Yuen
Research30 May 2010
Nature Biotechnology

Volume: 28, P: 600-605
Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus

P Forabosco
J D Gorman
L A Criswell
Research14 Sept 2006
Genes & Immunity

Volume: 7, P: 609-614
Comparing SARS-CoV-2 antigen-detection rapid diagnostic tests for COVID-19 self-testing/self-sampling with molecular and professional-use tests: a systematic review and meta-analysis

Stephan Katzenschlager
Lukas E. Brümmer
Seda Yerlikaya
ResearchOpen Access11 Dec 2023
Scientific Reports

Volume: 13, P: 1-15
The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma

Guo-Hua Qiu
Luke KS Tan
Qian Tao
Research03 May 2004
Oncogene

Volume: 23, P: 4793-4806
A human breast cancer model for the study of telomerase inhibitors based on a new biotinylated-primer extension assay

E Raymond
D Sun
D D Von Hoff
ResearchOpen Access11 Jun 1999
British Journal of Cancer

Volume: 80, P: 1332-1341
Loss of cell adhesion molecule L1 like promotes tumor growth and metastasis in esophageal squamous cell carcinoma

Hong Tang
Lingxi Jiang
Xin-Yuan Guan
Research08 Jan 2019
Oncogene

Volume: 38, P: 3119-3133
HOXC10 upregulation confers resistance to chemoradiotherapy in ESCC tumor cells and predicts poor prognosis

Daqin Suo
Zifeng Wang
Yan Li
Research25 Jun 2020
Oncogene

Volume: 39, P: 5441-5454
Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation

J Ying
H Li
Q Tao
Research10 Oct 2005
Oncogene

Volume: 25, P: 1070-1080
Mutations in GNAL cause primary torsion dystonia

Laurie Ozelius and colleagues identify mutations in GNAL in families with primary torsion dystonia, a movement disorder characterized by repetitive twisting muscle contractions and postures. GNAL encodes Gα_olf, a stimulatory G protein α subunit.

Tania Fuchs
Rachel Saunders-Pullman
Laurie J Ozelius
Research09 Dec 2012
Nature Genetics

Volume: 45, P: 88-92
Mc-hES, a novel plasmid carrying human endostatin gene, inhibits nasopharyngeal carcinoma growth

B-L Xu
L Yuan
W-L Huang
Research09 Dec 2011
Cancer Gene Therapy

Volume: 19, P: 110-117
Searching for parent-of-origin effects on cardiometabolic traits in imprinted genomic regions

Einat Granot-Hershkovitz
Peitao Wu
Hagit Hochner
Research02 Jan 2020
European Journal of Human Genetics

Volume: 28, P: 646-655
NRIP3 upregulation confers resistance to chemoradiotherapy in ESCC via RTF2 removal by accelerating ubiquitination and degradation of RTF2

Daqin Suo
Ling Wang
Yan Li
ResearchOpen Access24 Aug 2020
Oncogenesis

Volume: 9, P: 1-12
A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations

Pavithra Nagarajan
Thomas W. Winkler
Heming Wang
Research04 Apr 2025
Molecular Psychiatry

Volume: 30, P: 3660-3672
The interaction between C35 and ΔNp73 promotes chemo-resistance in ovarian cancer cells

T H-Y Leung
S C-S Wong
H Y-S Ngan
ResearchOpen Access23 Jul 2013
British Journal of Cancer

Volume: 109, P: 965-975
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

Matthew Meyerson and colleagues report that SOX2, which encodes a transcription factor necessary for normal esophageal development, is an amplified lineage survival oncogene in lung and esophageal squamous cell carcinomas.

Adam J Bass
Hideo Watanabe
Matthew Meyerson
Research04 Oct 2009
Nature Genetics

Volume: 41, P: 1238-1242
A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

Pancreatic cancer is not caused by a specific series of genetic alterations that occur sequentially but by one, or few, catastrophic events that result in simultaneous oncogenic genetic rearrangements, giving rise to highly aggressive tumours.

Faiyaz Notta
Michelle Chan-Seng-Yue
Steven Gallinger
Research12 Oct 2016
Nature

Volume: 538, P: 378-382
Distinct mechanisms of temporal binding in generalized and cross-modal flash-lag effects

Ryusuke Hayashi
Ikuya Murakami
ResearchOpen Access07 Mar 2019
Scientific Reports

Volume: 9, P: 1-12
Affinity of IL-2 receptors and proliferation of mitogen activated lymphocytes in Hodgkin's disease

RN Damle
RJ Tatake
SG Gangal
Research01 Mar 1990
British Journal of Cancer

Volume: 61, P: 404-406
Author Correction: Combined burden and functional impact tests for cancer driver discovery using DriverPower

Shimin Shuai
Federico Abascal
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer

Kadir C. Akdemir
Victoria T. Le
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1079
Author Correction: Pathway and network analysis of more than 2500 whole cancer genomes

Matthew A. Reyna
David Haan
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Bernardo Rodriguez-Martin
Eva G. Alvarez
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1080
Author Correction: Analyses of non-coding somatic drivers in 2,658 cancer whole genomes

Esther Rheinbay
Morten Muhlig Nielsen
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E40
Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns

Wei Jiao
Gurnit Atwal
Christian von Mering
Amendments and CorrectionsOpen Access08 Dec 2022
Nature Communications

Volume: 13, P: 1
Reversal of MDR1-associated resistance to topotecan by PAK-200S, a new dihydropyridine analogue, in human cancer cell lines

U Vanhoefer
M R Müller
A Harstrick
ResearchOpen Access26 Nov 1999
British Journal of Cancer

Volume: 81, P: 1304-1310

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