Nature Search

Controlled masking and targeted release of redox-cycling ortho-quinones via a C–C bond-cleaving 1,6-elimination

A strategy for protecting redox-active ortho-quinones, which show promise as anticancer agents but suffer from redox-cycling behaviour and systemic toxicity, has been developed. The ortho-quinones are derivatized to redox-inactive para-aminobenzyl ketols. Upon amine deprotection, an acid-promoted, self-immolative C–C bond-cleaving 1,6-elimination releases the redox-active hydroquinone. The strategy also enables conjugation to a carrier for targeted delivery of ortho-quinone species.

Lavinia Dunsmore
Claudio D. Navo
Gonçalo J. L. Bernardes
ResearchOpen Access27 Jun 2022
Nature Chemistry

Volume: 14, P: 754-765
Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer

Silva-Santos and colleagues provide in vivo preclinical evidence supporting a therapeutic use of Delta One T cells to tackle colorectal cancer and propose activating natural killer cell receptor NKG2D and blocking immune checkpoint receptors as possible combination therapies.

Rafael Blanco-Domínguez
Leandro Barros
Bruno Silva-Santos
ResearchOpen Access16 Apr 2025
Nature Cancer

Volume: 6, P: 1056-1072
TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets

The thymus produces γδ T cell subsets making either IFN-γ or IL-17. Silva-Santos and colleagues show that TCR signal strength within specific developmental windows is a major determinant of the generation of these γδ T cell subsets.

Miguel Muñoz-Ruiz
Julie C Ribot
Bruno Silva-Santos
Research04 Apr 2016
Nature Immunology

Volume: 17, P: 721-727
Computational insights and experimental breakthroughs in identifying next-generation acetylcholinesterase inhibitors

Devaraj Hanumanthappa
Bandral Sunil Kumar
Parasuraman Pavadai
ResearchOpen Access29 Aug 2025
Scientific Reports

Volume: 15, P: 1-20
CD27 is a thymic determinant of the balance between interferon-γ- and interleukin 17–producing γδ T cell subsets

In peripheral lymphoid organs, γδ T cells are a source of interleukin 17. Silva-Santos and colleagues find that production of interleukin 17 versus interferon-γ by γδ T cells is inflexible and is determined in the thymus.

Julie C Ribot
Ana deBarros
Bruno Silva-Santos
Research08 Mar 2009
Nature Immunology

Volume: 10, P: 427-436
Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

The development of post-chemotherapy resistance is a significant issue in the management of AML. Here, Caiado et al. suggest that the issue might be circumvented via upfront combination with hypomethylating agents that shape the clonal dynamics and transcriptional landscape of relapsing AML

Francisco Caiado
Diogo Maia-Silva
Bruno Silva-Santos
ResearchOpen Access01 Nov 2019
Nature Communications

Volume: 10, P: 1-15
Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R–STAT5B-driven neoplasms

Here the authors identify and characterize the development and function of an IFN-γ-producing CD8αβ⁺ subset of γδ T cells that contributes to malignancy.

Nital Sumaria
Gina J. Fiala
Bruno Silva-Santos
ResearchOpen Access27 May 2024
Nature Immunology

Volume: 25, P: 1207-1217
γδ T cell explorations seek terra firma

On 20–23 June 2023, the 10th International γδ T cell conference was held in Lisbon, Portugal, bringing together basic, translational and clinical researchers studying γδ T cells in health and disease.

Bruno Silva-Santos
Julie C. Ribot
Matthias Eberl
News & Views25 Sept 2023
Nature Immunology

Volume: 24, P: 1606-1609
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments

γδ T cells have potent effector functions through their production of IFN-γ or IL-17. Pennington and colleagues demonstrate that IFN-γ⁺ γδ T and IL-17⁺ γδ T cells have distinct metabolic requirements that can be independently targeted to elicit specific immune responses.

Noella Lopes
Claire McIntyre
Lydia Lynch
Research18 Jan 2021
Nature Immunology

Volume: 22, P: 179-192
Signature cytokine-associated transcriptome analysis of effector γδ T cells identifies subset-specific regulators of peripheral activation

Here, the authors use a double-reporter system to tag IFNγ-producing versus IL-17A-producing γδ T cells to compile a trancriptomic resource of these cell subsets in mice at steady state and in response to cerebral malaria or multiple sclerosis.

Daniel Inácio
Tiago Amado
Bruno Silva-Santos
ResearchOpen Access29 Jan 2025
Nature Immunology

Volume: 26, P: 497-510
Author Correction: Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

Francisco Caiado
Diogo Maia-Silva
Bruno Silva-Santos
Amendments and CorrectionsOpen Access26 Nov 2019
Nature Communications

Volume: 10, P: 1
Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets

Silva-Santos and colleagues use genome-wide characterization of the methylation patterns of histone H3 and analysis of transcription factor expression to identify the regulatory framework of peripheral interferon-γ-producing or interleukin 17–producing γδ T cell subsets.

Nina Schmolka
Karine Serre
Bruno Silva-Santos
Research01 Sept 2013
Nature Immunology

Volume: 14, P: 1093-1100
Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression

Lyden and colleagues find that immune developmental genes, such as apoptotic peptidase activating factor 1 (APAF1), support DNA packaging on the surface of tumor-derived extracellular vesicles that are taken up by resident liver macrophages, thereby suppressing metastasis.

Inbal Wortzel
Yura Seo
David Lyden
Research03 Dec 2024
Nature Cancer

Volume: 5, P: 1815-1833
Analysis of the prevalence, spread, and mutation patterns of SARS-CoV-2 variants: data from COVID-19 testing expansion strategy study in salvador, Northeast Brazil

Anna Carolina Saúde Dantas
Hellen Braga Martins Oliveira
Lucas Miranda Marques
ResearchOpen Access29 Aug 2025
Scientific Reports

Volume: 15, P: 1-15
IL-17⁺ γδ T cells as kick-starters of inflammation

Silva-Santos and colleagues review the activation and pathophysiological functions of γδ17 T cells during inflammatory responses.

Pedro H Papotto
Julie C Ribot
Bruno Silva-Santos
Reviews18 May 2017
Nature Immunology

Volume: 18, P: 604-611
Early events in the thymus affect the balance of effector and regulatory T cells

Daniel J. Pennington
Bruno Silva-Santos
Adrian C. Hayday
Research12 Nov 2006
Nature

Volume: 444, P: 1073-1077
Adipocyte lipolysis protects mice against Trypanosoma brucei infection

Infection by Trypanosoma brucei activates ATGL-dependent lipolysis in adipocytes, which reduces tissue parasite load and increases host survival.

Henrique Machado
Peter Hofer
Luísa M. Figueiredo
ResearchOpen Access12 Oct 2023
Nature Microbiology

Volume: 8, P: 2020-2032
γδ T cells in cancer

γδ T cells have unique specificities, high clonal frequencies and a pre-activated differentiation status that allow rapid and non-redundant responses to tumours. Here, the authors review their often contrasting roles in cancer and the opportunities for γδ T cell-based cancer therapies.

Bruno Silva-Santos
Karine Serre
Håkan Norell
Reviews09 Oct 2015
Nature Reviews Immunology

Volume: 15, P: 683-691
γδ T cells get adaptive

Throughout ontogeny, the γδ TCR repertoire in human blood becomes less diverse and more focused, yet is private in nature, and specific adult γδ T cell subsets undergo substantial clonal expansion after challenge with cytomegalovirus.

Bruno Silva-Santos
Jessica Strid
News & Views22 Mar 2017
Nature Immunology

Volume: 18, P: 370-372
Field and classroom initiatives for portable sequence-based monitoring of dengue virus in Brazil

Here, the authors present results of the ZiBRA-2 project (https://www.zibra2project.org) which is an arbovirus surveillance project, across the Midwest of Brazil using a mobile genomics laboratory, combined with a genomic surveillance training program that targeted post-graduate students, laboratory technicians, and health practitioners in universities and laboratories.

Talita Émile Ribeiro Adelino
Marta Giovanetti
Luiz Carlos Junior Alcantara
ResearchOpen Access16 Apr 2021
Nature Communications

Volume: 12, P: 1-12
γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis

Vγ6⁺ Vδ1⁺ γδ T cells control tolerance to cold by activating adipocyte IL-17RC and promoting sympathetic innervation of thermogenic adipose tissue in mice.

Bo Hu
Chengcheng Jin
Bruce M. Spiegelman
Research19 Feb 2020
Nature

Volume: 578, P: 610-614
γδ T cells maintain sensitivity to immunotherapy in MHC-I-deficient tumors

Research shows that Vδ1 and Vδ3 γδ T cells that express PD-1 and display potent cytotoxic functions are key immune responders in HLA-class-I-negative colon cancers subjected to immune checkpoint blockade therapy.

Bruno Silva-Santos
Sofia Mensurado
News & Views13 Feb 2023
Nature Immunology

Volume: 24, P: 387-388
Got my γδ17 T cells to keep me warm

γδ T cells accumulate with age in adipose tissue and produce the cytokine IL-17, which controls the homeostasis of regulatory T cells and adaptive thermogenesis. Thus, maintenance of core body temperature unexpectedly relies on these adipose tissue–resident γδ17 T cells.

Pedro H. Papotto
Bruno Silva-Santos
News & Views18 Apr 2018
Nature Immunology

Volume: 19, P: 427-429
Use of long-term underwater camera surveillance to assess the effects of the largest Amazonian hydroelectric dam on fish communities

Kurt Schmid
Friedrich Wolfgang Keppeler
Tommaso Giarrizzo
ResearchOpen Access27 Sept 2024
Scientific Reports

Volume: 14, P: 1-17
γδ T cells in tissue physiology and surveillance

This Review focuses on the roles of γδ T cells in tissue homeostasis and immune surveillance. The authors discuss exciting new studies showing how γδ T cells can regulate diverse physiological responses in tissues, ranging from thermogenesis in adipose tissue to remodelling at neuronal synapses.

Julie C. Ribot
Noëlla Lopes
Bruno Silva-Santos
Reviews14 Oct 2020
Nature Reviews Immunology

Volume: 21, P: 221-232
Translating gammadelta (γδ) T cells and their receptors into cancer cell therapies

γδT cells display potent cytotoxicity towards a large array of haematological and solid tumours while preserving normal tissues. In this Review, Sebestyen et al. analyse the tumour specificity mechanisms of γδT cells and the challenges and opportunities for the use of such cells and their receptors in cancer immunotherapy.

Zsolt Sebestyen
Immo Prinz
Jurgen Kuball
Reviews06 Sept 2019
Nature Reviews Drug Discovery

Volume: 19, P: 169-184
Pseudomonas flavocrustae sp. nov., an endophyte with plant growth promoting traits isolated from Passiflora incarnata

Luis Gabriel Cueva-Yesquén
Adilson Sartoratto
Fabiana Fantinatti-Garboggini
ResearchOpen Access21 Jun 2024
Scientific Reports

Volume: 14, P: 1-9
The emerging roles of γδ T cells in cancer immunotherapy

γδ T cells are lymphocytes with properties of both typical αβ T cell and natural killer cells, notable tissue tropisms, and MHC-independent antitumour functions that make them attractive agents for cancer immunotherapy. In this Review, the authors provide an overview of human γδ T cell subsets, discuss the antitumour and pro-tumour activities of these cells and their prognostic value in patients with cancer, and describe the current landscape of γδ T cell-based immunotherapies.

Sofia Mensurado
Rafael Blanco-Domínguez
Bruno Silva-Santos
Reviews09 Jan 2023
Nature Reviews Clinical Oncology

Volume: 20, P: 178-191
Crosstalk between γδ T cells and the microbiota

This Perspective discusses current knowledge of the complex crosstalk between the microbiota and γδ T cells and future outlooks.

Pedro H. Papotto
Bahtiyar Yilmaz
Bruno Silva-Santos
Reviews02 Aug 2021
Nature Microbiology

Volume: 6, P: 1110-1117
γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer

This Review discusses the rapidly accumulating preclinical evidence in support of antitumour, but also of some pro-tumour, roles for γδ T cells in cancer progression. It also outlines the potential for manipulating their functions for use as an unconventional form of cancer immunotherapy.

Bruno Silva-Santos
Sofia Mensurado
Seth B. Coffelt
Reviews17 Jun 2019
Nature Reviews Cancer

Volume: 19, P: 392-404
Specialized Tfh cell subsets driving type-1 and type-2 humoral responses in lymphoid tissue

Saumya Kumar
Afonso P. Basto
Luis Graca
ResearchOpen Access04 Jun 2024
Cell Discovery

Volume: 10, P: 1-21
Selection and validation of reference genes by RT-qPCR under photoperiodic induction of flowering in sugarcane (Saccharum spp.)

Paulo H. da Silva Santos
João R. Vieira Manechini
Luciana R. Pinto
ResearchOpen Access25 Feb 2021
Scientific Reports

Volume: 11, P: 1-10
Microbiota in health and diseases

Kaijian Hou
Zhuo-Xun Wu
Zhe-Sheng Chen
ReviewsOpen Access23 Apr 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-28
ATP sulfurylase atypical leucine zipper interacts with Cys3 and calcineurin A in the regulation of sulfur amino acid biosynthesis in Cryptococcus neoformans

Jeyson Pereira da Silva
Mariana Reis Meneghini
Renata Castiglioni Pascon
ResearchOpen Access20 Jul 2023
Scientific Reports

Volume: 13, P: 1-16
High-throughput analysis of the human thymic Vδ1⁺ T cell receptor repertoire

Biagio Di Lorenzo
Sarina Ravens
Bruno Silva-Santos
ResearchOpen Access04 Jul 2019
Scientific Data

Volume: 6, P: 1-8
A Plasmodium berghei sporozoite-based vaccination platform against human malaria

António M. Mendes
Marta Machado
Miguel Prudêncio
ResearchOpen Access24 Aug 2018
npj Vaccines

Volume: 3, P: 1-11
Microbiota-dependent expansion of testicular IL-17-producing Vγ6⁺ γδ T cells upon puberty promotes local tissue immune surveillance

Anneke Wilharm
Helena C. Brigas
Julie C. Ribot
ResearchOpen Access30 Jul 2020
Mucosal Immunology

Volume: 14, P: 242-252
Peripheral clonal selection shapes the human γδ T-cell repertoire

Biagio Di Lorenzo
Julie Déchanet-Merville
Bruno Silva-Santos
Research Highlights07 Aug 2017
Cellular & Molecular Immunology

Volume: 14, P: 733-735
Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling

S T Ribeiro
M Tesio
B Silva-Santos
ResearchOpen Access30 Nov 2016
Leukemia

Volume: 31, P: 1603-1610
Addendum: The FAIR Guiding Principles for scientific data management and stewardship

Mark D. Wilkinson
Michel Dumontier
Barend Mons
Amendments and CorrectionsOpen Access19 Mar 2019
Scientific Data

Volume: 6, P: 1-2
MOSAIC - A Unified Trait Database to Complement Structured Population Models

Connor Bernard
Gabriel Silva Santos
Roberto Salguero-Gómez
ResearchOpen Access01 Jun 2023
Scientific Data

Volume: 10, P: 1-15
The FAIR Guiding Principles for scientific data management and stewardship

Mark D. Wilkinson
Michel Dumontier
Barend Mons
Comments & OpinionOpen Access15 Mar 2016
Scientific Data

Volume: 3, P: 1-9

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