Histone H3 trimethylation at lysine 36 (H3K36me3) is associated with actively transcribed regions and may provide landmarks for continuing transcription. Here it is shown that the H3K36me3-specific histone methyltransferase Wolf-Hirschhorn syndrome candidate 1 (WHSC1) functions in transcription regulation together with developmental transcription factors whose defects overlap with the human disease Wolf-Hirschorn syndrome (WHS). Furthermore, Whsc1-deficient mice display defects similar to those seen in WHS patients.
- Keisuke Nimura
- Kiyoe Ura
- Yasufumi Kaneda
