Nature Search

Tucatinib plus trastuzumab for chemotherapy-refractory, HER2 + , RAS wild-type metastatic colorectal cancer (MOUNTAINEER): final analysis

The MOUNTAINEER phase 2 trial demonstrated the efficacy and safety of tucatinib (HER2-targeted TKI) and trastuzumab (anti-HER2 antibody) in patients with HER2 + , RAS wildtype unresectable or metastatic colorectal cancer that had progressed on chemotherapy, resulting in the approval of the regimen. Here, the authors report the updated analysis of the MOUNTAINEER trial.

John H. Strickler
Andrea Cercek
Tanios S. Bekaii-Saab
ResearchOpen Access12 Jan 2026
Nature Communications

Volume: 17, P: 1-12
E. coli chemosensing accuracy is not limited by stochastic molecule arrivals

The chemosensing accuracy of E. coli cells is shown to be limited by internal noise in signal processing, rather than the stochasticity of molecule arrivals at their receptors, contrary to long-held understanding in the field.

Henry H. Mattingly
Keita Kamino
Benjamin B. Machta
ResearchOpen Access08 Jan 2026
Nature Physics

Volume: 22, P: 123-130
Adherent cells sustain membrane tension gradients independently of migration

This study shows that adherent cells maintain membrane tension gradients even without moving. Using a fluorescent probe, the authors reveal that actin and adhesion forces shape these gradients, providing a new view of cell mechanics.

Juan Manuel García-Arcos
Amine Mehidi
Aurélien Roux
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-20
Serum p53 antibodies as early markers of lung cancer

Richard Lubin
Gerard Zalcman
Thierry Soussi
Research01 Jul 1995
Nature Medicine

Volume: 1, P: 701-702
Deciphering the genome structure and paleohistory of Theobroma cacao

Cristian Chaparro
Florent Murat
Mathilde Allegre
ResearchOpen Access16 Sept 2010
Nature Precedings

P: 1
Complete DNA sequence of yeast chromosome XI

B. Dujon
D. Alexandraki
H. W. Mewes
Research02 Jun 1994
Nature

Volume: 369, P: 371-378
Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction

Multi-ancestry genome-wide and transcriptome-wide association studies of aortic stenosis identify more than 200 independent risk loci and provide insights into its genetic architecture.

Aeron M. Small
Ta-Yu Yang
George Thanassoulis
ResearchOpen Access19 Dec 2025
Nature Genetics

Volume: 58, P: 57-66
2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

R. Wilson
R. Ainscough
P. Wohldman
Research03 Mar 1994
Nature

Volume: 368, P: 32-38
Inflammatory stromal and T cells mediate human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia

Clonal haematopoiesis of indeterminate potential is driven by somatic mutations in hematopoietic stem/progenitor cells and may progress to myelodysplastic syndromes (MDS). Here authors show that the two conditions share a similar pattern of bone marrow remodeling, characterized by the emergence of inflammatory mesenchymal stromal cells and IFN-responsive T cells, reinforcing their shared etio-pathology.

Karin D. Prummel
Kevin Woods
Borhane Guezguez
ResearchOpen Access18 Nov 2025
Nature Communications

Volume: 16, P: 1-25
Expediting hit-to-lead progression in drug discovery through reaction prediction and multi-dimensional optimization

Efficient lead optimization in drug discovery requires improving potency, synthetic accessibility, and physicochemical properties. Here, the authors utilize machine learning to screen large chemical spaces, demonstrating automated selection of optimized molecules to improve cycle times.

David F. Nippa
Kenneth Atz
Gisbert Schneider
ResearchOpen Access26 Nov 2025
Nature Communications

Volume: 16, P: 1-12
Crystal structure of yeast tRNA^Asp

D. Moras
M. B. Comarmond
R. Giegé
Research18 Dec 1980
Nature

Volume: 288, P: 669-674
Circumpolar spread of avian influenza H5N1 to southern Indian Ocean islands

The study reports the arrival of avian influenza H5N1 virus clade 2.3.4.4b into the Indian Ocean sub-Antarctic archipelagos of Crozet and Kerguelen. Using phylogeographic analyses, the virus likely came from the distant South Georgia islands.

Augustin Clessin
François-Xavier Briand
Thierry Boulinier
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-12
Characterization of liposome-mediated gene delivery: expression, stability and pharmacokinetics of plasmid DNA

AR Thierry
P Rabinovich
RC Gallo
Research01 Mar 1997
Gene Therapy

Volume: 4, P: 226-237
A meta-analysis of albuminuria as a surrogate endpoint for kidney failure

In a meta-analysis of 48 randomized trials of chronic kidney disease progression, reduction in the 6-month urinary albumin:creatinine ratio was associated with lower hazard ratios of established kidney disease endpoints, supporting the use of albuminuria change as a surrogate endpoint in clinical trials for chronic kidney disease.

Hiddo J. L. Heerspink
Willem H. Collier
Lesley A. Inker
Research06 Nov 2025
Nature Medicine

Volume: 32, P: 281-287
Crystal structure of aspartate decarboxylase at 2.2 Å resolution provides evidence for an ester in protein self–processing

Armando Albert
Venugopal Dhanaraj
Chris Abell
Research01 Apr 1998
Nature Structural Biology

Volume: 5, P: 289-293
Photonic streaking of attosecond pulse trains

An all-optical photonic streaking measurement is demonstrated that provides direct experimental access to individual attosecond pulses. The effects of non-adiabatic electron dynamics and plasma formation on the generated attosecond pulse train are directly observed when the pulse train is applied to harmonic generation in gases.

Kyung Taec Kim
Chunmei Zhang
F. Quéré
Research07 Jul 2013
Nature Photonics

Volume: 7, P: 651-656
Ferryl intermediates of catalase captured by time-resolved Weissenberg crystallography and UV-VIS spectroscopy

Patrice Gouet
Hélène-Marie Jouve
Janos Hajdu
Research01 Nov 1996
Nature Structural Biology

Volume: 3, P: 951-956
Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy

Klein and colleagues characterize 04_A06, a new V_H1-2-encoded broadly neutralizing antibody that has marked breadth and potency against extended multiclade HIV-1 pseudovirus panels and can maintain full viral suppression in HIV-1-infected humanized mice.

Lutz Gieselmann
Andrew T. DeLaitsch
Florian Klein
ResearchOpen Access06 Oct 2025
Nature Immunology

Volume: 26, P: 2016-2029
Cooperative tandem binding of met repressor of Escherichia coli

Simon E. V. Phillips
Iain Manfield
Peter G. Stockley
Research26 Oct 1989
Nature

Volume: 341, P: 711-715
The nucleotide sequence of Saccharomyces cerevisiae chromosome XV

B. Dujon
K. Albermann
K. Kleine
Research29 May 1997
Nature

Volume: 387, P: 98-102
Structure of an RNA double helix including uracil-uracil base pairs in an internal loop

Katrien J. Baeyens
Hendrik L. De Bondt
Stephen R. Holbrook
Research01 Jan 1995
Nature Structural Biology

Volume: 2, P: 56-62
Music in the first days of life

Daniela Perani
Maria Cristina Saccuman
Stefan Koelsch
ResearchOpen Access29 Jul 2008
Nature Precedings

P: 1
Broad versus limited gene panels to guide treatment in patients with advanced solid tumors: a randomized controlled trial

Results from the randomized ProfiLER-02 trial, which compared two gene panels in guiding molecular-based treatment in patients with solid tumors, show that a broader gene panel led to more molecular-based recommended therapies compared to a more limited gene panel.

Olivier Trédan
Damien Pouessel
Jean Yves Blay
ResearchOpen Access07 Apr 2025
Nature Medicine

Volume: 31, P: 1502-1508
Histamine H3 Receptor as a target for alcohol use disorder: challenging the predictability of animal models for clinical translation in drug development

Bernard Le Foll
Mickael Naassila
Jean Charles Schwartz
ResearchOpen Access29 Jan 2026
Translational Psychiatry

Volume: 16, P: 1-17
Inflammation and mutational burden differentially associated with nivolumab or ipilimumab combination efficacy in colorectal cancer

In the CheckMate 142 study, nivolumab (anti-PD-1) alone and in combination with ipilimumab (anti-CTLA-4) was shown to induce durable clinical benefit in patients with previously treated microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer. Here, the authors perform exploratory biomarker analysis of the CheckMate 142 study.

Ming Lei
Michael J. Overman
Scott Kopetz
ResearchOpen Access06 Oct 2025
Nature Communications

Volume: 16, P: 1-12
An improved method of encapsulation of doxorubicin in liposomes: pharmacological, toxicological and therapeutic evaluation

PC Gokhale
B Radhakrishnan
A Rahman
Research01 Jul 1996
British Journal of Cancer

Volume: 74, P: 43-48
Activation of lysophagy by a TBK1-SCF^FBXO3-TMEM192-TAX1BP1 axis in response to lysosomal damage

Damaged lysosomes are eliminated by lysophagy, yet the regulatory mechanisms of this process are not fully defined. Here, the authors identify that the TBK1-SCFFBXO3-TMEM192-TAX1BP1 axis is essential for lysosome degradation, with FBXO3 functioning in lysosome integrity.

Na Yeon Park
Doo Sin Jo
Dong-Hyung Cho
ResearchOpen Access28 Jan 2025
Nature Communications

Volume: 16, P: 1-15
PD-L1⁺ plasma cells suppress T lymphocyte responses in patients with sepsis and mouse sepsis models

Sepsis induces a period of immunosuppression which can be problematic in the face of subsequent infectious challenge. Here the authors show the presence of PD-L1 expressing regulatory plasma cells that can inhibit T cells in a murine model and in patients with sepsis.

Morgane Gossez
Clara Vigneron
Fabienne Venet
ResearchOpen Access28 Mar 2025
Nature Communications

Volume: 16, P: 1-17
Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage

Thierry Wirth, Philip Supply, Stefan Niemann and colleagues analyze 4,987 Mycobacterium tuberculosis strains of the Beijing lineage isolated from 99 countries. They report whole-genome sequencing of 110 representative strains, characterize global population structure and reconstruct the evolutionary history of this lineage.

Matthias Merker
Camille Blin
Thierry Wirth
Research19 Jan 2015
Nature Genetics

Volume: 47, P: 242-249
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications

P. Philippsen
K. Kleine
J. Hani
Research29 May 1997
Nature

Volume: 387, P: 93-98
Nanoparticles for the delivery of genes and drugs to human hepatocytes

Tadanori Yamada
Yasushi Iwasaki
Shun'ichi Kuroda
Research29 Jun 2003
Nature Biotechnology

Volume: 21, P: 885-890
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

Catherine Uyttenhove
Luc Pilotte
Benoît J Van den Eynde
Research21 Sept 2003
Nature Medicine

Volume: 9, P: 1269-1274
Sterile-neutrino search based on 259 days of KATRIN data

The analysis of the energy spectrum of 36 million tritium β-decay electrons recorded in 259 measurement days within the last 40 eV below the endpoint challenges the Neutrino-4 claim.

H. Acharya
M. Aker
G. Zeller
ResearchOpen Access03 Dec 2025
Nature

Volume: 648, P: 70-75
Non-invasive bird tagging

Delphine Michard
André Ancel
Géarard Wey
Research24 Aug 1995
Nature

Volume: 376, P: 649-650
Experience-dependent changes in cerebral activation during human REM sleep

Pierre Maquet
Steven Laureys
Axel Cleeremans
Research01 Aug 2000
Nature Neuroscience

Volume: 3, P: 831-836
Equatorial upwelling of phosphorus drives Atlantic N₂ fixation and Sargassum blooms

High near-surface nitrogen-fixation rates that promoted the recent growth of the Great Atlantic Sargassum Belt were tied to greater upwelling of phosphorus from the equatorial Atlantic, according to coral-bound nitrogen isotope records from the Caribbean.

Jonathan Jung
Nicolas N. Duprey
Alfredo Martínez-García
ResearchOpen Access05 Nov 2025
Nature Geoscience

Volume: 18, P: 1259-1265
Surprising return of deep convection to the subpolar North Atlantic Ocean in winter 2007–2008

Deep convection in the subpolar North Atlantic, an important component of the global ocean circulation, has been absent in recent years. Profiling float data from the Argo programme document the return of deep mixing to the subpolar gyre in both the Labrador and Irminger seas in the winter of 2007–2008.

Kjetil Våge
Robert S. Pickart
Mads H. Ribergaard
Research30 Nov 2008
Nature Geoscience

Volume: 2, P: 67-72
Quartet RNA reference materials improve the quality of transcriptomic data through ratio-based profiling

A new RNA reference set improves detection of differential expression in clinical settings.

Ying Yu
Wanwan Hou
Yuanting Zheng
ResearchOpen Access07 Sept 2023
Nature Biotechnology

Volume: 42, P: 1118-1132
Disordered zinc in Zn₄Sb₃ with phonon-glass and electron-crystal thermoelectric properties

G. Jeffrey Snyder
Mogens Christensen
Bo Brummerstedt Iversen
Research27 Jun 2004
Nature Materials

Volume: 3, P: 458-463
Data-driven federated learning in drug discovery with knowledge distillation

FLuID enables privacy-preserving knowledge sharing in drug discovery using knowledge distillation. The results show that the approach expands applicability domains and fosters collaboration across organizations without compromising data privacy or security.

Thierry Hanser
Ernst Ahlberg
Tomoya Yukawa
Research05 Mar 2025
Nature Machine Intelligence

Volume: 7, P: 423-436
The complete DNA sequence of yeast chromosome III

S. G. Oliver
Q. J. M. van der Aart
J. G. Sgouros
Research07 May 1992
Nature

Volume: 357, P: 38-46
Coupled climate–land-use interactions modulate projected heatwave intensification across Africa

Nonlinear climate and land-use interactions drive historical and future heatwave intensification across Africa, especially in Western South Africa, based on multivariate bias-correction and explainable AI applied to CMIP6 future projections.

Oluwafemi E. Adeyeri
Kazeem Abiodun Ishola
Tobi Eniolu Morakinyo
ResearchOpen Access07 Jan 2026
Communications Earth & Environment

Volume: 7, P: 1-18
Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease

By integrating large-scale genomic and proteomic data in cerebrospinal fluid and plasma, the authors identify 49 proteins linked to MRI markers of cerebral small vessel disease, highlighting extracellular matrix and immune pathways, with biomarker and therapeutic potential.

Ilana Caro
Daniel Western
Stéphanie Debette
ResearchOpen Access20 Nov 2025
Nature Aging

Volume: 5, P: 2514-2531
Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes

The anterograde movement of Golgi-derived vesicles requires the small GTPase RAB6, while its effector ELKS targets these vesicles to particular areas of the plasma membrane. Here the authors show that RAB6 and ELKS function in the biogenesis of melanosome, demonstrating that the secretory pathway can be directed towards intracellular organelles of endosomal origin.

Anand Patwardhan
Sabine Bardin
Cédric Delevoye
ResearchOpen Access13 Jun 2017
Nature Communications

Volume: 8, P: 1-14
The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements

Leming Shi
Leming Shi
William Slikker Jr
Research08 Sept 2006
Nature Biotechnology

Volume: 24, P: 1151-1161
The palaeogenetics of cat dispersal in the ancient world

Ancient DNA analysis of archaeological cat remains shows cats dispersed along trade routes from the Neolithic era onwards, while its gene pool shows admixture from multiple geographical sources and that the tabby allele originated in the Middle Ages.

Claudio Ottoni
Wim Van Neer
Eva-Maria Geigl
Research19 Jun 2017
Nature Ecology & Evolution

Volume: 1, P: 1-7
Many human L1 elements are capable of retrotransposition

Donna M. Sassaman
Beth A. Dombroski
Haig H. Kazazian Jr
Research01 May 1997
Nature Genetics

Volume: 16, P: 37-43
Structure of influenza virus haemagglutinin complexed with a neutralizing antibody

Thierry Bizebard
BenoÃ®t Gigant
Marcel Knossow
Research06 Jul 1995
Nature

Volume: 376, P: 92-94
Crystal Structure of the protein drug urate oxidase-inhibitor complex at 2.05 Å resolution

Nathalie Colloc'h
Mohamed El Hajji
Jean-Paul Mornon
Research01 Nov 1997
Nature Structural Biology

Volume: 4, P: 947-952
Helioseismic inference of the solar radiative opacity

Opacities are considered to be the source of the disagreement between theoretical solar models and helioseismic data. Here, the authors show solar opacity profiles derived from seismic inferences, which differs from theoretical values used in the solar models.

Gaël Buldgen
Jean-Christophe Pain
David P. Kilcrease
ResearchOpen Access27 Jan 2025
Nature Communications

Volume: 16, P: 1-14

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