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Showing 1–3 of 3 results
Advanced filters: Author: Benjamin G Chousterman Clear advanced filters
  • The authors discuss the dysregulated host response in sepsis and the use of biomarkers to gauge the immunological status of patients and potentially guide precision medicine. They also highlight potential immunomodulatory therapies for sepsis and discuss the future of sepsis clinical trials.

    • Matthijs Kox
    • Michael Bauer
    • Peter Pickkers
    Reviews
    Nature Reviews Nephrology
    P: 1-20
  • Angiopoietin-like 4 protein (ANGPTL4) is a regulator of lipoprotein metabolism whose role in atherosclerosis has been controversial. Here the authors show that ANGPTL4 deficiency in haematopoietic cells increases atherogenesis by promoting myeloid progenitor cell expansion and differentiation, foam cell formation and vascular inflammation.

    • Binod Aryal
    • Noemi Rotllan
    • Carlos Fernández-Hernando
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15
  • Damaged erythrocytes accumulate in various pathological conditions, such as hemolytic anemia, anemia of inflammation, and sickle cell disease. In mice challenged with damaged erythorcytes, a monocyte subset migrates to the liver (but not to the spleen), and this subset differentiates into a transient macrophage population that removes the damaged erythrocytes, thus preventing organ damage.

    • Igor Theurl
    • Ingo Hilgendorf
    • Filip K Swirski
    Research
    Nature Medicine
    Volume: 22, P: 945-951