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Systematic review and meta-analysis of preclinical studies

Preclinical systematic reviews look at scientific evidence addressing focused questions from animal research studies to inform future clinical research. In this Primer, Ineichen et al. discuss the best practices for conducting preclinical systematic reviews, promoting reproducibility and guiding translational research.

Benjamin Victor Ineichen
Ulrike Held
Kimberley Elaine Wever
Reviews03 Oct 2024
Nature Reviews Methods Primers

Volume: 4, P: 1-18
Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis

Carlijn R. Hooijmans
Martin Hlavica
Benjamin V. Ineichen
ResearchOpen Access29 Jan 2019
Scientific Reports

Volume: 9, P: 1-17
Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

It is believed that the bulk of cerebrospinal fluid (CSF) drains through arachnoid projections from the subarachnoid space to the dural venous sinuses. Here the authors show that the major outflow pathway for CSF in mice are lymphatic vessels and that this drainage decreases as the mice age.

Qiaoli Ma
Benjamin V. Ineichen
Steven T. Proulx
ResearchOpen Access10 Nov 2017
Nature Communications

Volume: 8, P: 1-13
Natural language processing analysis of the theories of people with multiple sclerosis about causes of their disease

Haag et al. examine the theories of persons with multiple sclerosis (MS) about the causes of MS using natural language processing techniques. Their study identifies unique topics and highlights the role of mental health and the need for an open dialogue about the scientific and mental health aspects of MS.

Christina Haag
Nina Steinemann
Viktor von Wyl
ResearchOpen Access24 Jun 2024
Communications Medicine

Volume: 4, P: 1-8
The translational potential of salvinorin A: systematic review and meta-analysis of preclinical studies

Wolfgang Emanuel Zürrer
Lionel Wettstein
Benjamin Victor Ineichen
ReviewsOpen Access10 Oct 2025
Translational Psychiatry

Volume: 15, P: 1-12
Direct, long-term intrathecal application of therapeutics to the rodent CNS

This protocol describes surgical techniques for long-term intrathecal drug administration to rodent CNS tissue and cerebrospinal fluid collection for monitoring of drug concentration and distribution.

Benjamin V Ineichen
Lisa Schnell
Martin E Schwab
Protocols15 Dec 2016
Nature Protocols

Volume: 12, P: 104-121
From data deluge to publomics: How AI can transform animal research

Benjamin V. Ineichen
Marianna Rosso
Malcolm R. Macleod
Correspondence27 Sept 2023
Lab Animal

Volume: 52, P: 213-214

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Systematic review and meta-analysis of preclinical studies

Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

Natural language processing analysis of the theories of people with multiple sclerosis about causes of their disease

The translational potential of salvinorin A: systematic review and meta-analysis of preclinical studies

Direct, long-term intrathecal application of therapeutics to the rodent CNS

From data deluge to publomics: How AI can transform animal research

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