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Using an experimental simulator of the extended Hubbard model with spin–valley isospins arising in chiral-stacked twisted double bilayer graphene, the presence of highly tunable quantum criticalities is demonstrated.

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

A dynamic Cu–Pt dual-atom catalyst supported on 1Tʹ-MoS₂ can be electrically switched between single- and dual-atom configurations, enabling on-demand control for alkyne semi-hydrogenation.

Quantum spin-ice phases are predicted to have emergent gauge fields and fractionalization. Neutron scattering and thermodynamic measurements of the quantum spin-ice candidate Ce₂Zr₂O₇ show features consistent with these predictions.

SNARE protein-mediated vesicle fusion is usually monitored by indirect lipid mixing. Diaoet al. have developed a FRET-based single-vesicle content mixing assay, which elucidates fusion pore formation, and shows that the yeast SNARE complex mediates pore expansion in the absence of accessory proteins.

Olefins are employed in many coupling procedures but direct hydrocarbonations of unactivated olefins remain to be developed. Here, the authors report the nickel-catalyzed reductive coupling of olefins with aryl and alky electrophiles under mild conditions and with a broad substrate scope.

The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

This study highlights the role Polar regions as a limiting factor in global sustainability due to teleconnection effects, and then propose a SDG target, key indicators, and emphasize Indigenous inclusion and global action.

Controlling phase transitions in MoOx semiconductors is challenging. Here, the authors develop a lab-on-device system to modulate proton intercalation, achieving conductance modulation and enabling electrochemical memory and neural network applications.

A microfluidic assay that quantifies cell migration and proliferation can prospectively categorize patients with glioblastoma according to progression-free survival.

CREBBP and KMT2D mutations frequently co-occur in B cell lymphomas with unclear significance. Here the authors show that they cooperate to skew B cell fate decisions and induce a CD8-depleted immune-evasive microenvironment to facilitate lymphomagenesis.

Controlled doping of organic semiconductors is required to enhance charge injection in organic electronics, but the lack of suitable n-dopants with small ionization energy remains elusive. Here, the authors report air-stable metals that act as strong n-dopants in molecules with chelating ligands.

There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

A novel covalent inhibitor, ISM3312, targets the main protease of multiple human coronaviruses, including drug-resistant strains, and shows broad antiviral activity. It offers a promising therapeutic strategy against current and future coronavirus threats.

Gene-edited mouse models are crucial for disease research but remain challenging to create. Here, authors introduce the CRISPR-VIM, using virus-like particles to efficiently deliver CRISPR tools into zygotes without physical damage, streamlining the creation of genetically engineered mouse models.

Flexible materials with mechano-responsive luminescence has gained interest for their potential in sensing devices. Here, the authors demonstrate targeted folding under high compressive strains, which, together with the oxygen quenching of fluorophores, forms the basis for topo-optical sensing.

Fullerene cages that break the isolated pentagon rule are rare and often unstable. Now a range of fullerenes that feature three sequentially fused pentagons of carbon have been stabilized by chlorination.

A wax-aided immersion methodology is developed to yield graphene rolls with tunable chiral angles; these graphene rolls exhibit promising chiral electronic properties beyond those of other carbon allotropes.

Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

Real-time sensing of biomarkers via the use of wearable devices is a major aim of personalised medicine. Here, authors demonstrate an on-line wearable microneedle patch for real-time capture and monitoring of universal cell-free DNA.

Gestational diabetes milletus (GDM) may have impairments on offspring health. Here, the authors suggest that the increase of EZH2 is an important reason for the disrupted DNA methylome in oocytes exposed to GDM, which may be associated with the transgenerational inheritance of the metabolic disorders.

The transmembrane P-glycoprotein (P-gp) pumps are known to promote drug resistance by enhancing drug efflux. Here, the authors deliver P-gp inhibitor and a chemotherapeutic agent using tumor blood vessel-targeting nanoparticle, to overcome drug resistance.

Succinylation of PD-L1 by carnitine palmitoyltransferase 1A (CPT1A) in melanoma leads to its degradation and enhanced T cell-dependent killing in vitro. Increasing CPT1A levels synergizes with anti-CTLA-4 treatment to suppress tumor growth in a mouse melanoma model.

Researchers exploit atomic quantum state control in a fully integrated photonic atomic spectroscopy chip to reduce the group velocity of light by a factor of 1,200 — the lowest group velocity ever reported for a solid-state material. The findings will enable the creation of on-chip nonlinear optical devices with enhanced quantum coherence operating at ultralow power levels.

Predicting the drug response of patients with cancer is crucial for implementing targeted therapy. Here, Su et al. make patient-derived cell lines and perform targeted sequencing and RNA-seq to identify CDKN2A/2B loss as a predictor of response to CDK4/6 inhibitors in esophageal squamous cell carcinoma.

Glioma is a complex disease, and prognosis can depend on clinical, genomic and radiological information. Here, the authors develop a multimodal fusion subtyping model to integrate data modalities for predicting glioma subtypes.

Cerebrospinal fluid circulating tumor DNA profiling had prognostic value in a cohort of 584 patients with lung cancer and central nervous system metastases, and could be used to inform personalized therapies.

Detecting spatially variable genes (SVGs) is a key challenge in spatial transcriptomics. Here, the authors present STANCE, a statistical model leveraging gene expression, spatial location, and cell type composition to identify SVGs and cell type-specific SVGs with rotation-invariant results using a two-stage testing approach.

Serine/threonine kinases (STKs) regulate the synthesis of capsular polysaccharide in bacteria through unclear mechanisms. Here, Tang et al. identify a protein that is phosphorylated by an STK and modulates the activity of a phosphoregulatory system in Streptococcus suis, thus linking STKs to capsular polysaccharide synthesis.

Acute-on-chronic liver failure (ACLF) is characterized by rapid deterioration of liver function in patients with chronic liver disease. Here, the authors show that BTLA expression in CD4⁺ T cells is associated with disease severity and inflammation in hepatitis B virus-related ACLF.

Confidently separating the photothermal effect from the generation of energetic charge carriers and quantifying their relative contribution to chemical reactions remain a great challenge in plasmon-mediated chemical reactions. Here, authors describe a strategy based on the construction of a plasmonic electrode coupled with photoelectrochemistry to quantitatively disentangle these two effects.

ATE1 is an essential gene in mammals and is recognized as a master regulator of cells. Here, the authors describe structural insights into human ATE1, revealing mechanisms that regulate arginylation activity in cells.

Some materials can display magnetic order despite having spin-singlet ground state on individual magnetic sites. This arises due to exchange interactions mixing excited crystal electric field states. Here, Gao et al study and example of such a system, Ni₂Mo₃O₈, and find that crystal electric field states in both the paramagnetic and antiferromagnetic states exhibit dispersive excitations.

The authors present a photocatalytic method to selectively oxidize glycerol to hydroxypyruvic acid over rubidium–iridium catalytic pairs on poly(heptazine imides) under visible-light illumination.

Bioresorbable neural implants offer a promising solution to the challenges of secondary surgeries required for the removal of implanted devices. Here, the authors introduce a fully bioresorbable flexible hybrid opto-electronic system for simultaneous electrophysiological recording and optogenetic stimulation.

Manipulation of controllable polarization evolutions is a big challenge. The authors fabricate the irregular moirés, identifying three distinct types of moiré domains with different patterns, modulating them by external mechanical force disturbing.

Molecular catalysts provide an ideal model system to investigate the relationship between active site structure and catalytic performance. Here, the authors explore how electrochemical CO reduction to methanol can be controlled through modification of the active cobalt site in cobalt phthalocyanine.