We developed novel polydopamine (PDA)-modified gelatin methacryloyl (GelMA) hydrogel nanofibers for sustained Secreted Frizzled-Related Protein 2 (SFRP2) release to promote peripheral nerve regeneration and angiogenesis synchronously. In vitro experiments demonstrated that these nanofibers significantly enhanced Schwann cell migration and endothelial cell tube formation. In a mouse model of peripheral nerve injury, the SFRP2-loaded nanofibers effectively promoted angiogenesis, nerve repair, and target muscle restoration via the calcineurin/NFATc3 signaling pathway. These findings suggest a promising therapeutic strategy for peripheral nerve injuries.
- Linjie Zhang
- Peng Qiu
- Minyi Yin