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Childhood of a phoenix: modern biology in Eastern and South-Eastern Europe

In the shadow of societal upheaval and transformation, Eastern and South-Eastern European countries have been undergoing major reforms of their scientific and academic landscapes. Although the reforms have been slow, the success of several molecular biology institutes has highlighted what can be achieved.

Bojan Zagrovic
Ivan Dikic
Comments & Opinion05 Mar 2008
Nature Reviews Molecular Cell Biology

Volume: 9, P: 333-336
Translon: a single term for translated regions

Michał I. Świrski
Jack A. S. Tierney
Pavel V. Baranov
Correspondence01 Sept 2025
Nature Methods

Volume: 22, P: 2002-2006
X-ray refinement significantly underestimates the level of microscopic heterogeneity in biomolecular crystals

The structural heterogeneity of a biomolecular crystal structure is typically captured using atomic B-factors, determined during structure refinement. Here, the authors use molecular dynamics to show that this strategy is flawed, and that crystallographic B-factors underestimate structural heterogeneity.

Antonija Kuzmanic
Navraj S. Pannu
Bojan Zagrovic
ResearchOpen Access07 Feb 2014
Nature Communications

Volume: 5, P: 1-10
Analogue encoding of physicochemical properties of proteins in their cognate messenger RNAs

mRNA transport contributes to the proper localization of its cognate proteins. Here the authors report a correlation between the physicochemical properties of mRNAs and their cognate proteins, suggesting that these properties of mRNAs can predict the subcellular localization of their cognate proteins.

Anton A. Polyansky
Mario Hlevnjak
Bojan Zagrovic
ResearchOpen Access20 Nov 2013
Nature Communications

Volume: 4, P: 1-11
Driving forces behind phase separation of the carboxy-terminal domain of RNA polymerase II

The condensation of RNA polymerase II (Pol II) into transcriptionally active clusters is critical for eukaryotic gene regulation and pre-mRNA transcription. Here the authors show that a tight network of tyrosine-proline interactions imparts temperature and concentration-dependent self-coacervation of Pol II’s C-terminal domain (CTD).

David Flores-Solis
Irina P. Lushpinskaia
Markus Zweckstetter
ResearchOpen Access25 Sept 2023
Nature Communications

Volume: 14, P: 1-15
The SPOC proteins DIDO3 and PHF3 co-regulate gene expression and neuronal differentiation

Death-inducer obliterator 3 (DIDO3) and PHD finger protein 3 (PHF3) are paralogue proteins that regulate transcription elongation by docking onto phosphorylated serine-2 in the C-terminal domain (CTD) of Pol II through their SPOC domains. Here the authors characterize the interplay of these proteins and show that they coregulate neuronal target genes.

Johannes Benedum
Vedran Franke
Dea Slade
ResearchOpen Access30 Nov 2023
Nature Communications

Volume: 14, P: 1-20
The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators

Here the authors establish the SPOC domain as a universal reader of the RNA Pol II CTD code and a versatile reader of phosphoserine marks found in co- and post-transcriptional regulators such as m6A writer and reader proteins.

Lisa-Marie Appel
Vedran Franke
Dea Slade
ResearchOpen Access11 Jan 2023
Nature Communications

Volume: 14, P: 1-22
Structural correspondence between the α-helix and the random-flight chain resolves how unfolded proteins can have native-like properties

Bojan Zagrovic
Vijay S Pande
Research12 Oct 2003
Nature Structural & Molecular Biology

Volume: 10, P: 955-961
Interaction preferences between protein side chains and key epigenetic modifications 5-methylcytosine, 5-hydroxymethycytosine and N⁶-methyladenine

Matea Hajnic
Santiago Alonso-Gil
Bojan Zagrovic
ResearchOpen Access15 Nov 2022
Scientific Reports

Volume: 12, P: 1-12

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