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Showing 1–5 of 5 results
Advanced filters: Author: Brad J. Nolen Clear advanced filters

  • Francis et al. used cryo-electron microscopy to show how a SPIN90 dimer activates the metazoan Arp2/3 complex to nucleate linear actin filaments for unidirectional and bidirectional growth, forming potential scaffolds for rapid assembly of dynamic actin networks.

    • Justus Francis
    • Achyutha Krishna Pathri
    • Saikat Chowdhury
    Research
    Nature Structural & Molecular Biology
    P: 1-13

  • Arp2/3 complex nucleates branched actin filaments, and is inactive in the absense of activators. Here the authors present a model of Arp2/3 autoinhibition, whereby the Arp3 C-terminal tail acts as a structural switch that blocks movement of Arp2 and Arp3 into an activated filament-like conformation.

    • Max Rodnick-Smith
    • Su-Ling Liu
    • Brad J. Nolen
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • The Arp2/3 complex regulates the actin cytoskeleton by nucleating branched actin filaments in response to cellular signals and is in turn controlled by regulators including GMF. The crystal structure of GMF bound to Arp2/3 provides insight into how GMF inhibits actin nucleation and dissembles branches.

    • Qing Luan
    • Brad J Nolen
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 1062-1068