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Showing 1–3 of 3 results
Advanced filters: Author: Brandyn R. West Clear advanced filters

  • Human antibodies cross-reactive for several viruses within the Ebolavirus genus have been identified. Here the authors present the crystal structure of such a neutralizing monoclonal antibody (mAb) targeting the stalk of Bundibugyo virus glycoprotein and show that mAb binding may interfere with trimeric bundle assembly and/or the viral membrane.

    • Liam B. King
    • Brandyn R. West
    • Erica Ollmann Saphire
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-8

  • The crystal structure of a broadly neutralizing monoclonal antibody against Ebola virus glycoprotein isolated from a human survivor allows the engineering of variant antibodies with expanded activity and has implications for vaccine design.

    • Brandyn R. West
    • Anna Z. Wec
    • Erica Ollmann Saphire
    Research
    Nature Structural & Molecular Biology
    Volume: 26, P: 204-212

  • Structural and functional characterization of two neutralizing antibodies that target conserved, nonoverlapping epitopes in HeV and NiV F protein trimers and inhibit membrane fusion establishes the therapeutic potential of antibody cocktails to protect against henipavirus infection.

    • Ha V. Dang
    • Robert W. Cross
    • David Veesler
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 426-434