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Peroxisomal metabolism of branched fatty acids regulates energy homeostasis

A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes in adipose tissue thermogenesis is identified.

Xuejing Liu
Anyuan He
Irfan J. Lodhi
ResearchOpen Access17 Sept 2025
Nature

P: 1-9
Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling

The peroxisomal β-oxidation enzyme ACOX1 increases in liver with obesity, but the physiological significance is unclear. Here, the authors show that liver-specific knockout of Acox1 leads to accumulation of omega-3 VLCFAs that promote metabolic health through activation of GPR120 in adipose tissue.

Dongliang Lu
Anyuan He
Irfan J. Lodhi
ResearchOpen Access17 May 2024
Nature Communications

Volume: 15, P: 1-16
TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis

Mitochondrial dynamics affect the thermogenic capacity of brown adipose tissue. Here, the authors show that TMEM135 regulates thermogenesis and energy homeostasis by mediating mitochondrial fission in brown adipocytes.

Donghua Hu
Min Tan
Irfan J. Lodhi
ResearchOpen Access29 Sept 2023
Nature Communications

Volume: 14, P: 1-20
Humoral and cellular response to the COVID-19 vaccine in immunocompromised children

Heather A. Morgans
Todd Bradley
Bradley Warady
Research14 Nov 2022
Pediatric Research

Volume: 94, P: 200-205

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Peroxisomal metabolism of branched fatty acids regulates energy homeostasis

Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling

TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis

Humoral and cellular response to the COVID-19 vaccine in immunocompromised children

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